Research areas

  • QC Physics - cell mechanics, cytoskeleton, active soft matter, extracellular matrix, rheology, mechanobiology, tissue mechanics

Research interests

The Biological Soft Matter group is an experimental research group centered around the soft matter physics of living matter. Our overall aim is to understand the physical mechanisms that govern the self-organization and (active) mechanics of cells and tissues. Our main strategy is to reconstitute synthetic cell models by biochemical reconstitution as well as synthetic tissue models based on cells grown in physiologically relevant extracellular matrices. We perform quantitative experiments based on quantitative light and electron microscopy, single-molecule force spectroscopy, optical microrheology, and macroscopic rheometry. We develop predictive models together with theoretical collaborators and apply physical insights to questions in cell and developmental biology together with biologists.

Research output

  1. In vitro reconstitution of dynamic co-organization of microtubules and actin filaments in emulsion droplets

    Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

  2. Cytolinker Gas2L1 regulates axon morphology through microtubule-modulated actin stabilization

    Research output: Contribution to journalArticleScientificpeer-review

  3. Colloidal Liquid Crystals Confined to Synthetic Tactoids

    Research output: Contribution to journalArticleScientificpeer-review

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