2D Representation of Transcriptomes by t-SNE Exposes Relatedness between Human Tissues

E Taskesen; MJT Reinders

doi:10.1371/journal.pone.0149853

2D Representation of Transcriptomes by t-SNE Exposes Relatedness between Human Tissues

E Taskesen, MJT Reinders

Pattern Recognition and Bioinformatics

Research output: Contribution to journal › Article › Scientific › peer-review

28 Citations (Scopus)

Abstract

The GTEx Consortium reported that hierarchical clustering of RNA profiles from 25 unique tissue types among 1641 individuals accurately distinguished the tissue types, but a multidimensional scaling failed to generate a 2D projection of the data that separates tissue-subtypes. In this study we show that a projection by t-Distributed Stochastic Neighbor Embedding is in line with the cluster analysis which allows a more detailed examination and visualization of human tissue relationships.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	PLoS ONE
Volume	11
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0149853
Publication status	Published - 23 Feb 2016

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2D Representation of Transcriptomes by t-SNE Exposes Relatedness between Human Tissues

Abstract

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