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A genome-wide association study identifies genetic loci associated with specific lobar brain volumes. / van der Lee, Sven J.; Knol, Maria J.; Chauhan, Ganesh; Satizabal, Claudia L.; Smith, Albert Vernon; Hofer, Edith; Bis, Joshua C.; van den Akker, Erik B.; Niessen, Wiro J.; More Authors.

In: Communications Biology, Vol. 2, No. 1, 285, 2019, p. 1-9.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

van der Lee, SJ, Knol, MJ, Chauhan, G, Satizabal, CL, Smith, AV, Hofer, E, Bis, JC, van den Akker, EB, Niessen, WJ & More Authors 2019, 'A genome-wide association study identifies genetic loci associated with specific lobar brain volumes', Communications Biology, vol. 2, no. 1, 285, pp. 1-9. https://doi.org/10.1038/s42003-019-0537-9

APA

van der Lee, S. J., Knol, M. J., Chauhan, G., Satizabal, C. L., Smith, A. V., Hofer, E., Bis, J. C., van den Akker, E. B., Niessen, W. J., & More Authors (2019). A genome-wide association study identifies genetic loci associated with specific lobar brain volumes. Communications Biology, 2(1), 1-9. [285]. https://doi.org/10.1038/s42003-019-0537-9

Vancouver

van der Lee SJ, Knol MJ, Chauhan G, Satizabal CL, Smith AV, Hofer E et al. A genome-wide association study identifies genetic loci associated with specific lobar brain volumes. Communications Biology. 2019;2(1):1-9. 285. https://doi.org/10.1038/s42003-019-0537-9

Author

van der Lee, Sven J. ; Knol, Maria J. ; Chauhan, Ganesh ; Satizabal, Claudia L. ; Smith, Albert Vernon ; Hofer, Edith ; Bis, Joshua C. ; van den Akker, Erik B. ; Niessen, Wiro J. ; More Authors. / A genome-wide association study identifies genetic loci associated with specific lobar brain volumes. In: Communications Biology. 2019 ; Vol. 2, No. 1. pp. 1-9.

BibTeX

@article{9a02a87b47ac4e5b801a2da9f70dd29f,
title = "A genome-wide association study identifies genetic loci associated with specific lobar brain volumes",
abstract = "Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We identified six genetic loci associated with specific lobar volumes independent of intracranial volume. Two loci, associated with occipital (6q22.32) and temporal lobe volume (12q14.3), were previously reported to associate with intracranial and hippocampal volume, respectively. We identified four loci previously unknown to affect brain volumes: 3q24 for parietal lobe volume, and 1q22, 4p16.3 and 14q23.1 for occipital lobe volume. The associated variants were located in regions enriched for histone modifications (DAAM1 and THBS3), or close to genes causing Mendelian brain-related diseases (ZIC4 and FGFRL1). No genetic overlap between lobar volumes and neurological or psychiatric diseases was observed. Our findings reveal part of the complex genetics underlying brain development and suggest a role for regulatory regions in determining brain volumes.",
author = "{van der Lee}, {Sven J.} and Knol, {Maria J.} and Ganesh Chauhan and Satizabal, {Claudia L.} and Smith, {Albert Vernon} and Edith Hofer and Bis, {Joshua C.} and {van den Akker}, {Erik B.} and Niessen, {Wiro J.} and {More Authors}",
year = "2019",
doi = "10.1038/s42003-019-0537-9",
language = "English",
volume = "2",
pages = "1--9",
journal = "Communications Biology",
issn = "2399-3642",
publisher = "Springer Nature",
number = "1",

}

RIS

TY - JOUR

T1 - A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

AU - van der Lee, Sven J.

AU - Knol, Maria J.

AU - Chauhan, Ganesh

AU - Satizabal, Claudia L.

AU - Smith, Albert Vernon

AU - Hofer, Edith

AU - Bis, Joshua C.

AU - van den Akker, Erik B.

AU - Niessen, Wiro J.

AU - More Authors, null

PY - 2019

Y1 - 2019

N2 - Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We identified six genetic loci associated with specific lobar volumes independent of intracranial volume. Two loci, associated with occipital (6q22.32) and temporal lobe volume (12q14.3), were previously reported to associate with intracranial and hippocampal volume, respectively. We identified four loci previously unknown to affect brain volumes: 3q24 for parietal lobe volume, and 1q22, 4p16.3 and 14q23.1 for occipital lobe volume. The associated variants were located in regions enriched for histone modifications (DAAM1 and THBS3), or close to genes causing Mendelian brain-related diseases (ZIC4 and FGFRL1). No genetic overlap between lobar volumes and neurological or psychiatric diseases was observed. Our findings reveal part of the complex genetics underlying brain development and suggest a role for regulatory regions in determining brain volumes.

AB - Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We identified six genetic loci associated with specific lobar volumes independent of intracranial volume. Two loci, associated with occipital (6q22.32) and temporal lobe volume (12q14.3), were previously reported to associate with intracranial and hippocampal volume, respectively. We identified four loci previously unknown to affect brain volumes: 3q24 for parietal lobe volume, and 1q22, 4p16.3 and 14q23.1 for occipital lobe volume. The associated variants were located in regions enriched for histone modifications (DAAM1 and THBS3), or close to genes causing Mendelian brain-related diseases (ZIC4 and FGFRL1). No genetic overlap between lobar volumes and neurological or psychiatric diseases was observed. Our findings reveal part of the complex genetics underlying brain development and suggest a role for regulatory regions in determining brain volumes.

UR - http://www.scopus.com/inward/record.url?scp=85071153870&partnerID=8YFLogxK

U2 - 10.1038/s42003-019-0537-9

DO - 10.1038/s42003-019-0537-9

M3 - Article

AN - SCOPUS:85071153870

VL - 2

SP - 1

EP - 9

JO - Communications Biology

JF - Communications Biology

SN - 2399-3642

IS - 1

M1 - 285

ER -

ID: 56660823