TY - JOUR
T1 - A meta-analysis of genome-wide association studies identifies multiple longevity genes
AU - Deelen, J
AU - D., Evans
AU - Dan E., Arking
AU - Tesi, Niccolo
AU - M, Nygaard
AU - Liu, Xiaoming
AU - Mary K., Wojczynski
AU - Reinders, Marcel
AU - Holstege, Henne
AU - More Authors, null
N1 - Correction DOI .1038/s41467-021-22613-2
PY - 2019
Y1 - 2019
N2 - Human longevity is heritable, but genome-wide association (GWA) studies have had limitedsuccess. Here, we perform two meta-analyses of GWA studies of a rigorous longevityphenotype definition including 11,262/3484 cases surviving at or beyond the age corre-sponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose ageat death or at last contact was at or below the age corresponding to the 60th survivalpercentile. Consistent with previous reports, rs429358 (apolipoprotein E (ApoE)ε4) isassociated with lower odds of surviving to the 90th and 99th percentile age, while rs7412(ApoEε2) shows the opposite. Moreover, rs7676745, located nearGPR78, associates withlower odds of surviving to the 90th percentile age. Gene-level association analysis reveals arole for tissue-specific expression of multiple genes in longevity. Finally, genetic correlation ofthe longevity GWA results with that of several disease-related phenotypes points to a sharedgenetic architecture between health and longevity
AB - Human longevity is heritable, but genome-wide association (GWA) studies have had limitedsuccess. Here, we perform two meta-analyses of GWA studies of a rigorous longevityphenotype definition including 11,262/3484 cases surviving at or beyond the age corre-sponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose ageat death or at last contact was at or below the age corresponding to the 60th survivalpercentile. Consistent with previous reports, rs429358 (apolipoprotein E (ApoE)ε4) isassociated with lower odds of surviving to the 90th and 99th percentile age, while rs7412(ApoEε2) shows the opposite. Moreover, rs7676745, located nearGPR78, associates withlower odds of surviving to the 90th percentile age. Gene-level association analysis reveals arole for tissue-specific expression of multiple genes in longevity. Finally, genetic correlation ofthe longevity GWA results with that of several disease-related phenotypes points to a sharedgenetic architecture between health and longevity
UR - http://www.scopus.com/inward/record.url?scp=85070746813&partnerID=8YFLogxK
U2 - 10.1038/s41467-019-11558-2
DO - 10.1038/s41467-019-11558-2
M3 - Article
SN - 2041-1723
VL - 10
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 3669
ER -
