Advancing single-molecule instrumentation through nanoscale optics, fabrication, and surface functionalization

Seungkyu Ha

doi:10.4233/uuid:addc45be-225e-4a52-acb6-59b3c967deb1

Advancing single-molecule instrumentation through nanoscale optics, fabrication, and surface functionalization

Seungkyu Ha

BN/Nynke Dekker Lab

Research output: Thesis › Dissertation (TU Delft)

217 Downloads (Pure)

Abstract

This thesis describes developments in the single-molecule instrumentation, in particular optical torque wrench and DNA nanocurtains, with the goal of employing these techniques in studies of biomolecules and biomotors. Importantly, the use of single-crystal rutile titanium dioxide nanocylinders is suggested for optical torque wrench, enabling access to a larger torque-speed space and improvement in spatiotemporal resolution.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Delft University of Technology
Supervisors/Advisors	Dekker, N.H., Supervisor
Award date	16 Oct 2018
Print ISBNs	978-90-8593-367-0
DOIs	https://doi.org/10.4233/uuid:addc45be-225e-4a52-acb6-59b3c967deb1
Publication status	Published - 2018

Bibliographical note

Casimir PhD Series 2018-37

Keywords

biophysics
single-molecule
nano-optics
nanofabrication
surface functionalization
optical tweezers
optical torque wrench
DNA nanocurtain
fluorescence microscopy

Access to Document

10.4233/uuid:addc45be-225e-4a52-acb6-59b3c967deb1

PhD_Thesis_S.HaFinal published version, 28.4 MBLicence: CC BY-NC-ND

Cite this

@phdthesis{addc45be225e4a52acb659b3c967deb1,

title = "Advancing single-molecule instrumentation through nanoscale optics, fabrication, and surface functionalization",

abstract = "This thesis describes developments in the single-molecule instrumentation, in particular optical torque wrench and DNA nanocurtains, with the goal of employing these techniques in studies of biomolecules and biomotors. Importantly, the use of single-crystal rutile titanium dioxide nanocylinders is suggested for optical torque wrench, enabling access to a larger torque-speed space and improvement in spatiotemporal resolution.",

keywords = "biophysics, single-molecule, nano-optics, nanofabrication, surface functionalization, optical tweezers, optical torque wrench, DNA nanocurtain, fluorescence microscopy",

author = "Seungkyu Ha",

note = "Casimir PhD Series 2018-37",

year = "2018",

doi = "10.4233/uuid:addc45be-225e-4a52-acb6-59b3c967deb1",

language = "English",

isbn = "978-90-8593-367-0",

type = "Dissertation (TU Delft)",

school = "Delft University of Technology",

}

TY - THES

T1 - Advancing single-molecule instrumentation through nanoscale optics, fabrication, and surface functionalization

AU - Ha, Seungkyu

N1 - Casimir PhD Series 2018-37

PY - 2018

Y1 - 2018

N2 - This thesis describes developments in the single-molecule instrumentation, in particular optical torque wrench and DNA nanocurtains, with the goal of employing these techniques in studies of biomolecules and biomotors. Importantly, the use of single-crystal rutile titanium dioxide nanocylinders is suggested for optical torque wrench, enabling access to a larger torque-speed space and improvement in spatiotemporal resolution.

AB - This thesis describes developments in the single-molecule instrumentation, in particular optical torque wrench and DNA nanocurtains, with the goal of employing these techniques in studies of biomolecules and biomotors. Importantly, the use of single-crystal rutile titanium dioxide nanocylinders is suggested for optical torque wrench, enabling access to a larger torque-speed space and improvement in spatiotemporal resolution.

KW - biophysics

KW - single-molecule

KW - nano-optics

KW - nanofabrication

KW - surface functionalization

KW - optical tweezers

KW - optical torque wrench

KW - DNA nanocurtain

KW - fluorescence microscopy

UR - http://resolver.tudelft.nl/uuid:addc45be-225e-4a52-acb6-59b3c967deb1

U2 - 10.4233/uuid:addc45be-225e-4a52-acb6-59b3c967deb1

DO - 10.4233/uuid:addc45be-225e-4a52-acb6-59b3c967deb1

M3 - Dissertation (TU Delft)

SN - 978-90-8593-367-0

ER -

Advancing single-molecule instrumentation through nanoscale optics, fabrication, and surface functionalization

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Quantifying the Precision of Single-Molecule Torque and Twist Measurements Using Allan Variance

Tunable top-down fabrication and functional surface coating of single-crystal titanium dioxide nanostructures and nanoparticles

Cite this