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Age-dependent association of thyroid function with brain morphology and microstructural organization : Evidence from brain imaging. / Chaker, Layal; Cremers, Lotte G M; Korevaar, Tim I.M.; De Groot, Marius; Dehghan, Abbas; Franco, Oscar H.; Niessen, Wiro J.; Ikram, M. Arfan; Peeters, Robin P.; Vernooij, Meike W.

In: Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, Vol. 61, 01.01.2018, p. 44-51.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Chaker, L, Cremers, LGM, Korevaar, TIM, De Groot, M, Dehghan, A, Franco, OH, Niessen, WJ, Ikram, MA, Peeters, RP & Vernooij, MW 2018, 'Age-dependent association of thyroid function with brain morphology and microstructural organization: Evidence from brain imaging' Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, vol. 61, pp. 44-51. https://doi.org/10.1016/j.neurobiolaging.2017.09.014

APA

Chaker, L., Cremers, L. G. M., Korevaar, T. I. M., De Groot, M., Dehghan, A., Franco, O. H., ... Vernooij, M. W. (2018). Age-dependent association of thyroid function with brain morphology and microstructural organization: Evidence from brain imaging. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 61, 44-51. https://doi.org/10.1016/j.neurobiolaging.2017.09.014

Vancouver

Chaker L, Cremers LGM, Korevaar TIM, De Groot M, Dehghan A, Franco OH et al. Age-dependent association of thyroid function with brain morphology and microstructural organization: Evidence from brain imaging. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology. 2018 Jan 1;61:44-51. https://doi.org/10.1016/j.neurobiolaging.2017.09.014

Author

Chaker, Layal ; Cremers, Lotte G M ; Korevaar, Tim I.M. ; De Groot, Marius ; Dehghan, Abbas ; Franco, Oscar H. ; Niessen, Wiro J. ; Ikram, M. Arfan ; Peeters, Robin P. ; Vernooij, Meike W. / Age-dependent association of thyroid function with brain morphology and microstructural organization : Evidence from brain imaging. In: Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology. 2018 ; Vol. 61. pp. 44-51.

BibTeX

@article{1995217f62a84535a68d80dad116a463,
title = "Age-dependent association of thyroid function with brain morphology and microstructural organization: Evidence from brain imaging",
abstract = "Thyroid hormone (TH) is crucial during neurodevelopment, but high levels of TH have been linked to neurodegenerative disorders. No data on the association of thyroid function with brain imaging in the general population are available. We therefore investigated the association of thyroid-stimulating hormone and free thyroxine (FT4) with magnetic resonance imaging (MRI)-derived total intracranial volume, brain tissue volumes, and diffusion tensor imaging measures of white matter microstructure in 4683 dementia- and stroke-free participants (mean age 60.2, range 45.6–89.9 years). Higher FT4 levels were associated with larger total intracranial volumes (β = 6.73 mL, 95{\%} confidence interval = 2.94–9.80). Higher FT4 levels were also associated with larger total brain and white matter volumes in younger individuals, but with smaller total brain and white matter volume in older individuals (p-interaction 0.02). There was a similar interaction by age for the association of FT4 with mean diffusivity on diffusion tensor imaging (p-interaction 0.026). These results are in line with differential effects of TH during neurodevelopmental and neurodegenerative processes and can improve the understanding of the role of thyroid function in neurodegenerative disorders.",
keywords = "Brain microstructural organization, Brain morphology, Diffusion tensor imaging, Thyroid function",
author = "Layal Chaker and Cremers, {Lotte G M} and Korevaar, {Tim I.M.} and {De Groot}, Marius and Abbas Dehghan and Franco, {Oscar H.} and Niessen, {Wiro J.} and Ikram, {M. Arfan} and Peeters, {Robin P.} and Vernooij, {Meike W.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.neurobiolaging.2017.09.014",
language = "English",
volume = "61",
pages = "44--51",
journal = "Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology",
issn = "0197-4580",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Age-dependent association of thyroid function with brain morphology and microstructural organization

T2 - Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology

AU - Chaker, Layal

AU - Cremers, Lotte G M

AU - Korevaar, Tim I.M.

AU - De Groot, Marius

AU - Dehghan, Abbas

AU - Franco, Oscar H.

AU - Niessen, Wiro J.

AU - Ikram, M. Arfan

AU - Peeters, Robin P.

AU - Vernooij, Meike W.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Thyroid hormone (TH) is crucial during neurodevelopment, but high levels of TH have been linked to neurodegenerative disorders. No data on the association of thyroid function with brain imaging in the general population are available. We therefore investigated the association of thyroid-stimulating hormone and free thyroxine (FT4) with magnetic resonance imaging (MRI)-derived total intracranial volume, brain tissue volumes, and diffusion tensor imaging measures of white matter microstructure in 4683 dementia- and stroke-free participants (mean age 60.2, range 45.6–89.9 years). Higher FT4 levels were associated with larger total intracranial volumes (β = 6.73 mL, 95% confidence interval = 2.94–9.80). Higher FT4 levels were also associated with larger total brain and white matter volumes in younger individuals, but with smaller total brain and white matter volume in older individuals (p-interaction 0.02). There was a similar interaction by age for the association of FT4 with mean diffusivity on diffusion tensor imaging (p-interaction 0.026). These results are in line with differential effects of TH during neurodevelopmental and neurodegenerative processes and can improve the understanding of the role of thyroid function in neurodegenerative disorders.

AB - Thyroid hormone (TH) is crucial during neurodevelopment, but high levels of TH have been linked to neurodegenerative disorders. No data on the association of thyroid function with brain imaging in the general population are available. We therefore investigated the association of thyroid-stimulating hormone and free thyroxine (FT4) with magnetic resonance imaging (MRI)-derived total intracranial volume, brain tissue volumes, and diffusion tensor imaging measures of white matter microstructure in 4683 dementia- and stroke-free participants (mean age 60.2, range 45.6–89.9 years). Higher FT4 levels were associated with larger total intracranial volumes (β = 6.73 mL, 95% confidence interval = 2.94–9.80). Higher FT4 levels were also associated with larger total brain and white matter volumes in younger individuals, but with smaller total brain and white matter volume in older individuals (p-interaction 0.02). There was a similar interaction by age for the association of FT4 with mean diffusivity on diffusion tensor imaging (p-interaction 0.026). These results are in line with differential effects of TH during neurodevelopmental and neurodegenerative processes and can improve the understanding of the role of thyroid function in neurodegenerative disorders.

KW - Brain microstructural organization

KW - Brain morphology

KW - Diffusion tensor imaging

KW - Thyroid function

UR - http://resolver.tudelft.nl/uuid:1995217f-62a8-4535-a68d-80dad116a463

UR - http://www.scopus.com/inward/record.url?scp=85034818290&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2017.09.014

DO - 10.1016/j.neurobiolaging.2017.09.014

M3 - Article

VL - 61

SP - 44

EP - 51

JO - Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology

JF - Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology

SN - 0197-4580

ER -

ID: 33423966