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An automated hybrid bioelectronic system for autogenous restoration of sinus rhythm in atrial fibrillation. / Nyns, Emile C.A.; Poelma, René H.; Volkers, Linda; Plomp, Jaap J.; Bart, Cindy I.; Kip, Annemarie M.; van Brakel, Thomas J.; Zeppenfeld, Katja; Schalij, Martin J.; Zhang, Guo Qi; de Vries, Antoine A.F.; Pijnappels, Daniël A.

In: Science Translational Medicine, Vol. 11, No. 481, eaau6447, 2019, p. 1-11.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Nyns, ECA, Poelma, RH, Volkers, L, Plomp, JJ, Bart, CI, Kip, AM, van Brakel, TJ, Zeppenfeld, K, Schalij, MJ, Zhang, GQ, de Vries, AAF & Pijnappels, DA 2019, 'An automated hybrid bioelectronic system for autogenous restoration of sinus rhythm in atrial fibrillation', Science Translational Medicine, vol. 11, no. 481, eaau6447, pp. 1-11. https://doi.org/10.1126/scitranslmed.aau6447

APA

Nyns, E. C. A., Poelma, R. H., Volkers, L., Plomp, J. J., Bart, C. I., Kip, A. M., van Brakel, T. J., Zeppenfeld, K., Schalij, M. J., Zhang, G. Q., de Vries, A. A. F., & Pijnappels, D. A. (2019). An automated hybrid bioelectronic system for autogenous restoration of sinus rhythm in atrial fibrillation. Science Translational Medicine, 11(481), 1-11. [eaau6447]. https://doi.org/10.1126/scitranslmed.aau6447

Vancouver

Author

Nyns, Emile C.A. ; Poelma, René H. ; Volkers, Linda ; Plomp, Jaap J. ; Bart, Cindy I. ; Kip, Annemarie M. ; van Brakel, Thomas J. ; Zeppenfeld, Katja ; Schalij, Martin J. ; Zhang, Guo Qi ; de Vries, Antoine A.F. ; Pijnappels, Daniël A. / An automated hybrid bioelectronic system for autogenous restoration of sinus rhythm in atrial fibrillation. In: Science Translational Medicine. 2019 ; Vol. 11, No. 481. pp. 1-11.

BibTeX

@article{066de737c4254ba3a7255efaeab15cc6,
title = "An automated hybrid bioelectronic system for autogenous restoration of sinus rhythm in atrial fibrillation",
abstract = "Because of suboptimal therapeutic strategies, restoration of sinus rhythm in symptomatic atrial fibrillation (AF) often requires in-hospital delivery of high-voltage shocks, thereby precluding ambulatory AF termination. Continuous, rapid restoration of sinus rhythm is desired given the recurring and progressive nature of AF. Here, we present an automated hybrid bioelectronic system for shock-free termination of AF that enables the heart to act as an electric current generator for autogenous restoration of sinus rhythm. We show that local, right atrial delivery of adenoassociated virus vectors encoding a light-gated depolarizing ion channel results in efficient and spatially confined transgene expression. Activation of an implanted intrathoracic light-emitting diode device allows for termination of AF by illuminating part of the atria. Combining this newly obtained antiarrhythmic effector function of the heart with the arrhythmia detector function of a machine-based cardiac rhythm monitor in the closed chest of adult rats allowed automated and rapid arrhythmia detection and termination in a safe, effective, repetitive, yet shock-free manner. These findings hold translational potential for the development of shock-free antiarrhythmic device therapy for ambulatory treatment of AF.",
author = "Nyns, {Emile C.A.} and Poelma, {Ren{\'e} H.} and Linda Volkers and Plomp, {Jaap J.} and Bart, {Cindy I.} and Kip, {Annemarie M.} and {van Brakel}, {Thomas J.} and Katja Zeppenfeld and Schalij, {Martin J.} and Zhang, {Guo Qi} and {de Vries}, {Antoine A.F.} and Pijnappels, {Dani{\"e}l A.}",
year = "2019",
doi = "10.1126/scitranslmed.aau6447",
language = "English",
volume = "11",
pages = "1--11",
journal = "Science Translational Medicine",
issn = "1946-6234",
publisher = "American Association for the Advancement of Science",
number = "481",

}

RIS

TY - JOUR

T1 - An automated hybrid bioelectronic system for autogenous restoration of sinus rhythm in atrial fibrillation

AU - Nyns, Emile C.A.

AU - Poelma, René H.

AU - Volkers, Linda

AU - Plomp, Jaap J.

AU - Bart, Cindy I.

AU - Kip, Annemarie M.

AU - van Brakel, Thomas J.

AU - Zeppenfeld, Katja

AU - Schalij, Martin J.

AU - Zhang, Guo Qi

AU - de Vries, Antoine A.F.

AU - Pijnappels, Daniël A.

PY - 2019

Y1 - 2019

N2 - Because of suboptimal therapeutic strategies, restoration of sinus rhythm in symptomatic atrial fibrillation (AF) often requires in-hospital delivery of high-voltage shocks, thereby precluding ambulatory AF termination. Continuous, rapid restoration of sinus rhythm is desired given the recurring and progressive nature of AF. Here, we present an automated hybrid bioelectronic system for shock-free termination of AF that enables the heart to act as an electric current generator for autogenous restoration of sinus rhythm. We show that local, right atrial delivery of adenoassociated virus vectors encoding a light-gated depolarizing ion channel results in efficient and spatially confined transgene expression. Activation of an implanted intrathoracic light-emitting diode device allows for termination of AF by illuminating part of the atria. Combining this newly obtained antiarrhythmic effector function of the heart with the arrhythmia detector function of a machine-based cardiac rhythm monitor in the closed chest of adult rats allowed automated and rapid arrhythmia detection and termination in a safe, effective, repetitive, yet shock-free manner. These findings hold translational potential for the development of shock-free antiarrhythmic device therapy for ambulatory treatment of AF.

AB - Because of suboptimal therapeutic strategies, restoration of sinus rhythm in symptomatic atrial fibrillation (AF) often requires in-hospital delivery of high-voltage shocks, thereby precluding ambulatory AF termination. Continuous, rapid restoration of sinus rhythm is desired given the recurring and progressive nature of AF. Here, we present an automated hybrid bioelectronic system for shock-free termination of AF that enables the heart to act as an electric current generator for autogenous restoration of sinus rhythm. We show that local, right atrial delivery of adenoassociated virus vectors encoding a light-gated depolarizing ion channel results in efficient and spatially confined transgene expression. Activation of an implanted intrathoracic light-emitting diode device allows for termination of AF by illuminating part of the atria. Combining this newly obtained antiarrhythmic effector function of the heart with the arrhythmia detector function of a machine-based cardiac rhythm monitor in the closed chest of adult rats allowed automated and rapid arrhythmia detection and termination in a safe, effective, repetitive, yet shock-free manner. These findings hold translational potential for the development of shock-free antiarrhythmic device therapy for ambulatory treatment of AF.

UR - http://www.scopus.com/inward/record.url?scp=85062343163&partnerID=8YFLogxK

U2 - 10.1126/scitranslmed.aau6447

DO - 10.1126/scitranslmed.aau6447

M3 - Article

C2 - 30814339

AN - SCOPUS:85062343163

VL - 11

SP - 1

EP - 11

JO - Science Translational Medicine

JF - Science Translational Medicine

SN - 1946-6234

IS - 481

M1 - eaau6447

ER -

ID: 52158644