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Association of Alzheimer's disease GWAS loci with MRI markers of brain aging. / Chauhan, Ganesh; Adams, Hieab H.H.; Bis, Joshua C.; Weinstein, Galit; Yu, Lei; Töglhofer, Anna Maria; Smith, Albert Vernon; van der Lee, Sven J.; Gottesman, Rebecca F.; Niessen, Wiro J.; More Authors.

In: Neurobiology of Aging, Vol. 36, No. 4, 2015, p. 1765.e7-1765.e16.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Chauhan, G, Adams, HHH, Bis, JC, Weinstein, G, Yu, L, Töglhofer, AM, Smith, AV, van der Lee, SJ, Gottesman, RF, Niessen, WJ & More Authors 2015, 'Association of Alzheimer's disease GWAS loci with MRI markers of brain aging' Neurobiology of Aging, vol. 36, no. 4, pp. 1765.e7-1765.e16. https://doi.org/10.1016/j.neurobiolaging.2014.12.028

APA

Chauhan, G., Adams, H. H. H., Bis, J. C., Weinstein, G., Yu, L., Töglhofer, A. M., ... More Authors (2015). Association of Alzheimer's disease GWAS loci with MRI markers of brain aging. Neurobiology of Aging, 36(4), 1765.e7-1765.e16. https://doi.org/10.1016/j.neurobiolaging.2014.12.028

Vancouver

Chauhan G, Adams HHH, Bis JC, Weinstein G, Yu L, Töglhofer AM et al. Association of Alzheimer's disease GWAS loci with MRI markers of brain aging. Neurobiology of Aging. 2015;36(4):1765.e7-1765.e16. https://doi.org/10.1016/j.neurobiolaging.2014.12.028

Author

Chauhan, Ganesh ; Adams, Hieab H.H. ; Bis, Joshua C. ; Weinstein, Galit ; Yu, Lei ; Töglhofer, Anna Maria ; Smith, Albert Vernon ; van der Lee, Sven J. ; Gottesman, Rebecca F. ; Niessen, Wiro J. ; More Authors. / Association of Alzheimer's disease GWAS loci with MRI markers of brain aging. In: Neurobiology of Aging. 2015 ; Vol. 36, No. 4. pp. 1765.e7-1765.e16.

BibTeX

@article{008ee806ec9541a3a212afd212c8f69d,
title = "Association of Alzheimer's disease GWAS loci with MRI markers of brain aging",
abstract = "Whether novel risk variants of Alzheimer's disease (AD) identified through genome-wide association studies also influence magnetic resonance imaging-based intermediate phenotypes of AD in the general population is unclear. We studied association of 24 AD risk loci with intracranial volume, total brain volume, hippocampal volume (HV), white matter hyperintensity burden, and brain infarcts in a meta-analysis of genetic association studies from large population-based samples (N= 8175-11,550). In single-SNP based tests, AD risk allele of APOE (rs2075650) was associated with smaller HV (. p= 0.0054) and CD33 (rs3865444) with smaller intracranial volume (. p= 0.0058). In gene-based tests, there was associations of HLA-DRB1 with total brain volume (. p= 0.0006) and BIN1 with HV (. p= 0.00089). Aweighted AD genetic risk score was associated with smaller HV (beta ± SE=-0.047 ± 0.013, p= 0.00041), even after excluding the APOE locus (. p= 0.029). However, only association of AD genetic risk score with HV, including APOE, was significant after multiple testing correction (including number of independent phenotypes tested). These results suggest that novel AD genetic risk variants may contribute to structural brain aging in nondemented older community persons.",
keywords = "Alzheimer, Genetic risk score, GWAS, Hippocampal volume, MRI-Markers",
author = "Ganesh Chauhan and Adams, {Hieab H.H.} and Bis, {Joshua C.} and Galit Weinstein and Lei Yu and T{\"o}glhofer, {Anna Maria} and Smith, {Albert Vernon} and {van der Lee}, {Sven J.} and Gottesman, {Rebecca F.} and Niessen, {Wiro J.} and {More Authors}",
year = "2015",
doi = "10.1016/j.neurobiolaging.2014.12.028",
language = "English",
volume = "36",
pages = "1765.e7--1765.e16",
journal = "Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology",
issn = "0197-4580",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Association of Alzheimer's disease GWAS loci with MRI markers of brain aging

AU - Chauhan, Ganesh

AU - Adams, Hieab H.H.

AU - Bis, Joshua C.

AU - Weinstein, Galit

AU - Yu, Lei

AU - Töglhofer, Anna Maria

AU - Smith, Albert Vernon

AU - van der Lee, Sven J.

AU - Gottesman, Rebecca F.

AU - Niessen, Wiro J.

AU - More Authors, null

PY - 2015

Y1 - 2015

N2 - Whether novel risk variants of Alzheimer's disease (AD) identified through genome-wide association studies also influence magnetic resonance imaging-based intermediate phenotypes of AD in the general population is unclear. We studied association of 24 AD risk loci with intracranial volume, total brain volume, hippocampal volume (HV), white matter hyperintensity burden, and brain infarcts in a meta-analysis of genetic association studies from large population-based samples (N= 8175-11,550). In single-SNP based tests, AD risk allele of APOE (rs2075650) was associated with smaller HV (. p= 0.0054) and CD33 (rs3865444) with smaller intracranial volume (. p= 0.0058). In gene-based tests, there was associations of HLA-DRB1 with total brain volume (. p= 0.0006) and BIN1 with HV (. p= 0.00089). Aweighted AD genetic risk score was associated with smaller HV (beta ± SE=-0.047 ± 0.013, p= 0.00041), even after excluding the APOE locus (. p= 0.029). However, only association of AD genetic risk score with HV, including APOE, was significant after multiple testing correction (including number of independent phenotypes tested). These results suggest that novel AD genetic risk variants may contribute to structural brain aging in nondemented older community persons.

AB - Whether novel risk variants of Alzheimer's disease (AD) identified through genome-wide association studies also influence magnetic resonance imaging-based intermediate phenotypes of AD in the general population is unclear. We studied association of 24 AD risk loci with intracranial volume, total brain volume, hippocampal volume (HV), white matter hyperintensity burden, and brain infarcts in a meta-analysis of genetic association studies from large population-based samples (N= 8175-11,550). In single-SNP based tests, AD risk allele of APOE (rs2075650) was associated with smaller HV (. p= 0.0054) and CD33 (rs3865444) with smaller intracranial volume (. p= 0.0058). In gene-based tests, there was associations of HLA-DRB1 with total brain volume (. p= 0.0006) and BIN1 with HV (. p= 0.00089). Aweighted AD genetic risk score was associated with smaller HV (beta ± SE=-0.047 ± 0.013, p= 0.00041), even after excluding the APOE locus (. p= 0.029). However, only association of AD genetic risk score with HV, including APOE, was significant after multiple testing correction (including number of independent phenotypes tested). These results suggest that novel AD genetic risk variants may contribute to structural brain aging in nondemented older community persons.

KW - Alzheimer

KW - Genetic risk score

KW - GWAS

KW - Hippocampal volume

KW - MRI-Markers

UR - http://www.scopus.com/inward/record.url?scp=84925295495&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2014.12.028

DO - 10.1016/j.neurobiolaging.2014.12.028

M3 - Article

VL - 36

SP - 1765.e7-1765.e16

JO - Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology

T2 - Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology

JF - Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology

SN - 0197-4580

IS - 4

ER -

ID: 47148624