TY - JOUR
T1 - Bidirectional Bioelectronic Interfaces: System Design and Circuit Implications
T2 - System Design and Circuit Implications
AU - Liu, Yan
AU - Urso, Alessandro
AU - Martins Da Ponte, Ronaldo
AU - Costa, Tiago
AU - Valente, Virgilio
AU - Giagka, Vasiliki
AU - Serdijn, Wouter A.
AU - Constandinou, Timothy G.
AU - Denison, Timothy
PY - 2020
Y1 - 2020
N2 - The total economic cost of neurological disorders exceeds £100 billion per annum in the United Kingdom alone, yet pharmaceutical companies continue to cut investments due to failed clinical studies and risk [1]. These challenges motivate an alternative to solely pharmacological treatments. The emerging field of bioelectronics suggests a novel alternative to pharmaceutical intervention that uses electronic hardware to directly stimulate the nervous system with physiologically inspired electrical signals [2]. Given the processing capability of electronics and precise targeting of electrodes, the potential advantages of bioelectronics include specificity in the time, method, and location of treatment, with the ability to iteratively refine and update therapy algorithms in software [3]. A primary disadvantage of the current systems is invasiveness due to surgical implantation of the device. © 2009-2012 IEEE.
AB - The total economic cost of neurological disorders exceeds £100 billion per annum in the United Kingdom alone, yet pharmaceutical companies continue to cut investments due to failed clinical studies and risk [1]. These challenges motivate an alternative to solely pharmacological treatments. The emerging field of bioelectronics suggests a novel alternative to pharmaceutical intervention that uses electronic hardware to directly stimulate the nervous system with physiologically inspired electrical signals [2]. Given the processing capability of electronics and precise targeting of electrodes, the potential advantages of bioelectronics include specificity in the time, method, and location of treatment, with the ability to iteratively refine and update therapy algorithms in software [3]. A primary disadvantage of the current systems is invasiveness due to surgical implantation of the device. © 2009-2012 IEEE.
KW - Timing circuits
KW - Bio-electronic interface
KW - Clinical study
KW - Electrical signal
KW - Electronic hardwares
KW - Neurological disorders
KW - Pharmaceutical company
KW - Pharmacological treatment
KW - Processing capability
KW - Iterative methods
UR - http://www.scopus.com/inward/record.url?scp=85087498463&partnerID=8YFLogxK
U2 - 10.1109/MSSC.2020.2987506
DO - 10.1109/MSSC.2020.2987506
M3 - Article
SN - 1943-0582
VL - 12
SP - 30
EP - 46
JO - IEEE Solid State Circ. Mag.
JF - IEEE Solid State Circ. Mag.
IS - 2
ER -