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Change in carotid intraplaque hemorrhage in communitydwelling subjects : A follow-up study using serial MR imaging. / Van Den Bouwhuijsen, Quirijn J.A.; Selwaness, Mariana; Tang, Hui; Niessen, Wiro J.; Hofman, Albert; Franco, Oscar H.; Van Der Lugt, Aad; Vernooij, Meike W.

In: Radiology, Vol. 282, No. 2, 01.03.2017, p. 526-533.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Van Den Bouwhuijsen, QJA, Selwaness, M, Tang, H, Niessen, WJ, Hofman, A, Franco, OH, Van Der Lugt, A & Vernooij, MW 2017, 'Change in carotid intraplaque hemorrhage in communitydwelling subjects: A follow-up study using serial MR imaging' Radiology, vol. 282, no. 2, pp. 526-533. https://doi.org/10.1148/radiol.2016151806

APA

Van Den Bouwhuijsen, Q. J. A., Selwaness, M., Tang, H., Niessen, W. J., Hofman, A., Franco, O. H., ... Vernooij, M. W. (2017). Change in carotid intraplaque hemorrhage in communitydwelling subjects: A follow-up study using serial MR imaging. Radiology, 282(2), 526-533. https://doi.org/10.1148/radiol.2016151806

Vancouver

Van Den Bouwhuijsen QJA, Selwaness M, Tang H, Niessen WJ, Hofman A, Franco OH et al. Change in carotid intraplaque hemorrhage in communitydwelling subjects: A follow-up study using serial MR imaging. Radiology. 2017 Mar 1;282(2):526-533. https://doi.org/10.1148/radiol.2016151806

Author

Van Den Bouwhuijsen, Quirijn J.A. ; Selwaness, Mariana ; Tang, Hui ; Niessen, Wiro J. ; Hofman, Albert ; Franco, Oscar H. ; Van Der Lugt, Aad ; Vernooij, Meike W. / Change in carotid intraplaque hemorrhage in communitydwelling subjects : A follow-up study using serial MR imaging. In: Radiology. 2017 ; Vol. 282, No. 2. pp. 526-533.

BibTeX

@article{8504521da98d482f860419da80d0fe0f,
title = "Change in carotid intraplaque hemorrhage in communitydwelling subjects: A follow-up study using serial MR imaging",
abstract = "Purpose: To investigate intraplaque hemorrhage (IPH) development and change over time. Materials and Methods: Institutional review board approval and written informed consent from all participants were obtained. From a population-based study on subclinical atherosclerosis, 40 participants with IPH at baseline magnetic resonance (MR) imaging (53 carotids with IPH) were randomly selected and were matched with 27 control subjects (53 carotids without IPH) to undergo a second MR examination (mean interval, 17 months 6 4 [standard deviation]) to assess IPH change. IPH volume change was evaluated by using both a visual rating scale and an automated volumetric segmentation tool. Cardiovascular risk factors for IPH volume change were investigated with linear regression analyses. Results: IPH remained present in 50 (94{\%}) of the 53 carotids with IPH at baseline, and it developed in fve (7{\%}) of the 40 carotids without IPH at baseline. Visual progression of IPH volume was present in 14 (26{\%}) of the 53 carotids with IPH at baseline, and regression was present in 16 (30{\%}). Mean quantitative change in IPH volume was 213.7 mm3 ± 62.6 per year of follow-up. Male sex (men vs women, 37.7 mm3; 95{\%} confdence interval [CI]: 11.0, 64.4; P =.006), smoking (smokers vs nonsmokers, 45.2 mm3; 95{\%} CI: 7.1, 83.4; P =.020), and hypertension (subjects with hypertension vs those without hypertension, 32.5 mm3; 95{\%} CI: 7.7, 57.2; P =.010) were associated with IPH volume change. Conclusion: During 17 months of follow-up, both visual progression and regression of IPH volume occurs, whereas quantitatively IPH volume decreases. This suggests that IPH is a dynamic process with potential for either growth or resolution over time.",
author = "{Van Den Bouwhuijsen}, {Quirijn J.A.} and Mariana Selwaness and Hui Tang and Niessen, {Wiro J.} and Albert Hofman and Franco, {Oscar H.} and {Van Der Lugt}, Aad and Vernooij, {Meike W.}",
year = "2017",
month = "3",
day = "1",
doi = "10.1148/radiol.2016151806",
language = "English",
volume = "282",
pages = "526--533",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Change in carotid intraplaque hemorrhage in communitydwelling subjects

T2 - Radiology

AU - Van Den Bouwhuijsen, Quirijn J.A.

AU - Selwaness, Mariana

AU - Tang, Hui

AU - Niessen, Wiro J.

AU - Hofman, Albert

AU - Franco, Oscar H.

AU - Van Der Lugt, Aad

AU - Vernooij, Meike W.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Purpose: To investigate intraplaque hemorrhage (IPH) development and change over time. Materials and Methods: Institutional review board approval and written informed consent from all participants were obtained. From a population-based study on subclinical atherosclerosis, 40 participants with IPH at baseline magnetic resonance (MR) imaging (53 carotids with IPH) were randomly selected and were matched with 27 control subjects (53 carotids without IPH) to undergo a second MR examination (mean interval, 17 months 6 4 [standard deviation]) to assess IPH change. IPH volume change was evaluated by using both a visual rating scale and an automated volumetric segmentation tool. Cardiovascular risk factors for IPH volume change were investigated with linear regression analyses. Results: IPH remained present in 50 (94%) of the 53 carotids with IPH at baseline, and it developed in fve (7%) of the 40 carotids without IPH at baseline. Visual progression of IPH volume was present in 14 (26%) of the 53 carotids with IPH at baseline, and regression was present in 16 (30%). Mean quantitative change in IPH volume was 213.7 mm3 ± 62.6 per year of follow-up. Male sex (men vs women, 37.7 mm3; 95% confdence interval [CI]: 11.0, 64.4; P =.006), smoking (smokers vs nonsmokers, 45.2 mm3; 95% CI: 7.1, 83.4; P =.020), and hypertension (subjects with hypertension vs those without hypertension, 32.5 mm3; 95% CI: 7.7, 57.2; P =.010) were associated with IPH volume change. Conclusion: During 17 months of follow-up, both visual progression and regression of IPH volume occurs, whereas quantitatively IPH volume decreases. This suggests that IPH is a dynamic process with potential for either growth or resolution over time.

AB - Purpose: To investigate intraplaque hemorrhage (IPH) development and change over time. Materials and Methods: Institutional review board approval and written informed consent from all participants were obtained. From a population-based study on subclinical atherosclerosis, 40 participants with IPH at baseline magnetic resonance (MR) imaging (53 carotids with IPH) were randomly selected and were matched with 27 control subjects (53 carotids without IPH) to undergo a second MR examination (mean interval, 17 months 6 4 [standard deviation]) to assess IPH change. IPH volume change was evaluated by using both a visual rating scale and an automated volumetric segmentation tool. Cardiovascular risk factors for IPH volume change were investigated with linear regression analyses. Results: IPH remained present in 50 (94%) of the 53 carotids with IPH at baseline, and it developed in fve (7%) of the 40 carotids without IPH at baseline. Visual progression of IPH volume was present in 14 (26%) of the 53 carotids with IPH at baseline, and regression was present in 16 (30%). Mean quantitative change in IPH volume was 213.7 mm3 ± 62.6 per year of follow-up. Male sex (men vs women, 37.7 mm3; 95% confdence interval [CI]: 11.0, 64.4; P =.006), smoking (smokers vs nonsmokers, 45.2 mm3; 95% CI: 7.1, 83.4; P =.020), and hypertension (subjects with hypertension vs those without hypertension, 32.5 mm3; 95% CI: 7.7, 57.2; P =.010) were associated with IPH volume change. Conclusion: During 17 months of follow-up, both visual progression and regression of IPH volume occurs, whereas quantitatively IPH volume decreases. This suggests that IPH is a dynamic process with potential for either growth or resolution over time.

UR - http://www.scopus.com/inward/record.url?scp=85013632980&partnerID=8YFLogxK

U2 - 10.1148/radiol.2016151806

DO - 10.1148/radiol.2016151806

M3 - Article

VL - 282

SP - 526

EP - 533

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 2

ER -

ID: 37463100