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Concurrent white and gray matter degeneration of disease-specific networks in early-stage Alzheimer's disease and behavioral variant frontotemporal dementia. / Steketee, Rebecca M E; Meijboom, Rozanna; de Groot, Marius; Bron, Esther E.; Niessen, Wiro J.; van der Lugt, Aad; van Swieten, John C.; Smits, Marion.

In: Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, Vol. 43, 2016, p. 119-128.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Steketee, RME, Meijboom, R, de Groot, M, Bron, EE, Niessen, WJ, van der Lugt, A, van Swieten, JC & Smits, M 2016, 'Concurrent white and gray matter degeneration of disease-specific networks in early-stage Alzheimer's disease and behavioral variant frontotemporal dementia' Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, vol. 43, pp. 119-128. https://doi.org/10.1016/j.neurobiolaging.2016.03.031

APA

Steketee, R. M. E., Meijboom, R., de Groot, M., Bron, E. E., Niessen, W. J., van der Lugt, A., ... Smits, M. (2016). Concurrent white and gray matter degeneration of disease-specific networks in early-stage Alzheimer's disease and behavioral variant frontotemporal dementia. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 43, 119-128. https://doi.org/10.1016/j.neurobiolaging.2016.03.031

Vancouver

Steketee RME, Meijboom R, de Groot M, Bron EE, Niessen WJ, van der Lugt A et al. Concurrent white and gray matter degeneration of disease-specific networks in early-stage Alzheimer's disease and behavioral variant frontotemporal dementia. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology. 2016;43:119-128. https://doi.org/10.1016/j.neurobiolaging.2016.03.031

Author

Steketee, Rebecca M E ; Meijboom, Rozanna ; de Groot, Marius ; Bron, Esther E. ; Niessen, Wiro J. ; van der Lugt, Aad ; van Swieten, John C. ; Smits, Marion. / Concurrent white and gray matter degeneration of disease-specific networks in early-stage Alzheimer's disease and behavioral variant frontotemporal dementia. In: Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology. 2016 ; Vol. 43. pp. 119-128.

BibTeX

@article{c9e878dba813410fb62404c4c0992b96,
title = "Concurrent white and gray matter degeneration of disease-specific networks in early-stage Alzheimer's disease and behavioral variant frontotemporal dementia",
abstract = "This study investigates regional coherence between white matter (WM) microstructure and gray matter (GM) volume and perfusion measures in Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) using a correlational approach. WM-GM coherence, compared with controls, was stronger between cingulum WM and frontotemporal GM in AD, and temporoparietal GM in bvFTD. In addition, in AD compared with controls, coherence was stronger between inferior fronto-occipital fasciculus WM microstructure and occipital GM perfusion. In this first study assessing regional WM-GM coherence in AD and bvFTD, we show that WM microstructure and GM volume and perfusion measures are coherent, particularly in regions implicated in AD and bvFTD pathology. This indicates concurrent degeneration in disease-specific networks. Our methodology allows for the detection of incipient abnormalities that go undetected in conventional between-group analyses.",
keywords = "Alzheimer's disease, Arterial spin labeling, Behavioral variant frontotemporal dementia, Diffusion tensor imaging, Structural MRI",
author = "Steketee, {Rebecca M E} and Rozanna Meijboom and {de Groot}, Marius and Bron, {Esther E.} and Niessen, {Wiro J.} and {van der Lugt}, Aad and {van Swieten}, {John C.} and Marion Smits",
year = "2016",
doi = "10.1016/j.neurobiolaging.2016.03.031",
language = "English",
volume = "43",
pages = "119--128",
journal = "Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology",
issn = "0197-4580",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Concurrent white and gray matter degeneration of disease-specific networks in early-stage Alzheimer's disease and behavioral variant frontotemporal dementia

AU - Steketee, Rebecca M E

AU - Meijboom, Rozanna

AU - de Groot, Marius

AU - Bron, Esther E.

AU - Niessen, Wiro J.

AU - van der Lugt, Aad

AU - van Swieten, John C.

AU - Smits, Marion

PY - 2016

Y1 - 2016

N2 - This study investigates regional coherence between white matter (WM) microstructure and gray matter (GM) volume and perfusion measures in Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) using a correlational approach. WM-GM coherence, compared with controls, was stronger between cingulum WM and frontotemporal GM in AD, and temporoparietal GM in bvFTD. In addition, in AD compared with controls, coherence was stronger between inferior fronto-occipital fasciculus WM microstructure and occipital GM perfusion. In this first study assessing regional WM-GM coherence in AD and bvFTD, we show that WM microstructure and GM volume and perfusion measures are coherent, particularly in regions implicated in AD and bvFTD pathology. This indicates concurrent degeneration in disease-specific networks. Our methodology allows for the detection of incipient abnormalities that go undetected in conventional between-group analyses.

AB - This study investigates regional coherence between white matter (WM) microstructure and gray matter (GM) volume and perfusion measures in Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) using a correlational approach. WM-GM coherence, compared with controls, was stronger between cingulum WM and frontotemporal GM in AD, and temporoparietal GM in bvFTD. In addition, in AD compared with controls, coherence was stronger between inferior fronto-occipital fasciculus WM microstructure and occipital GM perfusion. In this first study assessing regional WM-GM coherence in AD and bvFTD, we show that WM microstructure and GM volume and perfusion measures are coherent, particularly in regions implicated in AD and bvFTD pathology. This indicates concurrent degeneration in disease-specific networks. Our methodology allows for the detection of incipient abnormalities that go undetected in conventional between-group analyses.

KW - Alzheimer's disease

KW - Arterial spin labeling

KW - Behavioral variant frontotemporal dementia

KW - Diffusion tensor imaging

KW - Structural MRI

UR - http://www.scopus.com/inward/record.url?scp=84966430598&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2016.03.031

DO - 10.1016/j.neurobiolaging.2016.03.031

M3 - Article

VL - 43

SP - 119

EP - 128

JO - Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology

T2 - Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology

JF - Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology

SN - 0197-4580

ER -

ID: 9625738