Construction of correlation networks with explicit time-slices using time-lagged, variable interval standard and partial correlation coefficients

W Meuleman, MCM Welten, FJ Verbeek

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

Abstract

Theconstructionofgeneregulatorymodelsfrommicroarraytime-seriesdatahasreceivedmuchattention.Hereweproposeamethodthatextendsstandardcorrelationnetworkstoincorporateexplicittimeslices.Themethodisappliedtoatime-seriesdatasetofastudyongeneexpressioninthedevelopmentalphaseofzebra¿sh.Resultsshowthatthemethodisabletodistinguishrealrelationsbetweengenesfromthedata.Theserelationsareexplicitlyplacedintime,allowingforabetterunderstandingofgeneregulation.ThemethodanddatanormalisationprocedurehavebeenimplementedusingtheRstatisticallanguageandareavailablefromhttp://zebrafish.liacs.nl/supplements.html.
Original languageUndefined/Unknown
Title of host publicationComputational Life Sciences II
EditorsMR Berthold, R. Glen, I. Fischer
Place of PublicationBerlin-Heidelberg
PublisherSpringer
Pages236-246
Number of pages11
ISBN (Print)3-540-45767-4
Publication statusPublished - 2006
EventSecond International Symposium, CompLife 2006, Cambridge, UK - Berlin-Heidelberg
Duration: 27 Sept 200629 Sept 2006

Publication series

Name
PublisherSpringer
Name
Volume4216

Conference

ConferenceSecond International Symposium, CompLife 2006, Cambridge, UK
Period27/09/0629/09/06

Bibliographical note

Dit is opgenomen in Lecturen Notes in Bioinformatics (4216) maar dit komt niet voor op de lijst en het lukt mij ook niet om het toe te voegen

Keywords

  • conference contrib. refereed
  • Conf.proc. > 3 pag

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