TY - JOUR
T1 - Contour segmentation of the intima, media, and adventitia layers in intracoronary OCT images
T2 - application to fully automatic detection of healthy wall regions
AU - Zahnd, Guillaume
AU - Hoogendoorn, Ayla
AU - Combaret, Nicolas
AU - Karanasos, Antonios
AU - Péry, Emilie
AU - Sarry, Laurent
AU - Motreff, Pascal
AU - Niessen, Wiro
AU - Regar, Evelyn
AU - van Soest, Gijs
AU - Gijsen, Frank
AU - van Walsum, Theo
PY - 2017
Y1 - 2017
N2 - Purpose: Quantitative and automatic analysis of intracoronary optical coherence tomography images is useful and time-saving to assess cardiovascular risk in the clinical arena. Methods: First, the interfaces of the intima, media, and adventitia layers are segmented, by means of an original front propagation scheme, running in a 4D multi-parametric space, to simultaneously extract three non-crossing contours in the initial cross-sectional image. Second, information resulting from the tentative contours is exploited by a machine learning approach to identify healthy and diseased regions of the arterial wall. The framework is fully automatic. Results: The method was applied to 40 patients from two different medical centers. The framework was trained on 140 images and validated on 260 other images. For the contour segmentation method, the average segmentation errors were 29±46μm for the intima–media interface, 30±50μm for the media–adventitia interface, and 50±64μm for the adventitia–periadventitia interface. The classification method demonstrated a good accuracy, with a median Dice coefficient equal to 0.93 and an interquartile range of (0.78–0.98). Conclusion: The proposed framework demonstrated promising offline performances and could potentially be translated into a reliable tool for various clinical applications, such as quantification of tissue layer thickness and global summarization of healthy regions in entire pullbacks.
AB - Purpose: Quantitative and automatic analysis of intracoronary optical coherence tomography images is useful and time-saving to assess cardiovascular risk in the clinical arena. Methods: First, the interfaces of the intima, media, and adventitia layers are segmented, by means of an original front propagation scheme, running in a 4D multi-parametric space, to simultaneously extract three non-crossing contours in the initial cross-sectional image. Second, information resulting from the tentative contours is exploited by a machine learning approach to identify healthy and diseased regions of the arterial wall. The framework is fully automatic. Results: The method was applied to 40 patients from two different medical centers. The framework was trained on 140 images and validated on 260 other images. For the contour segmentation method, the average segmentation errors were 29±46μm for the intima–media interface, 30±50μm for the media–adventitia interface, and 50±64μm for the adventitia–periadventitia interface. The classification method demonstrated a good accuracy, with a median Dice coefficient equal to 0.93 and an interquartile range of (0.78–0.98). Conclusion: The proposed framework demonstrated promising offline performances and could potentially be translated into a reliable tool for various clinical applications, such as quantification of tissue layer thickness and global summarization of healthy regions in entire pullbacks.
KW - Contour segmentation
KW - Coronary artery
KW - Machine learning
KW - Optical coherence tomography
UR - http://www.scopus.com/inward/record.url?scp=85027331627&partnerID=8YFLogxK
U2 - 10.1007/s11548-017-1657-7
DO - 10.1007/s11548-017-1657-7
M3 - Article
C2 - 28801817
AN - SCOPUS:85027331627
SN - 1861-6410
VL - 12
SP - 1923
EP - 1936
JO - International Journal of Computer Assisted Radiology and Surgery
JF - International Journal of Computer Assisted Radiology and Surgery
IS - 11
ER -