Deazaflavins as photocatalysts for the direct reductive regeneration of flavoenzymes

M. M.C.H. van Schie; S. H.H. Younes; M. C.R. Rauch; M. Pesic; C. E. Paul; I. W.C.E. Arends; F. Hollmann

doi:10.1016/j.mcat.2018.04.015

Deazaflavins as photocatalysts for the direct reductive regeneration of flavoenzymes

M. M.C.H. van Schie, S. H.H. Younes, M. C.R. Rauch, M. Pesic, C. E. Paul, I. W.C.E. Arends, F. Hollmann^*

^*Corresponding author for this work

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Abstract

Deazaflavins are potentially useful redox mediators for the direct, nicotinamide-independent regeneration of oxidoreductases. Especially the O₂-stability of their reduced forms have attracted significant interest for the regeneration of monooxygenases. In this contribution we further investigate the photochemical properties of deazaflavins and investigate the scope and limitations of deazaflavin-based photoenzymatic reaction systems.

Original language	English
Pages (from-to)	277-283
Number of pages	7
Journal	Molecular Catalysis
Volume	452
DOIs	https://doi.org/10.1016/j.mcat.2018.04.015
Publication status	Published - 2018

Bibliographical note

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

Keywords

Biocatalysis
Flavin
Old yellow enzyme
Oxygen dilemma
Photochemistry

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10.1016/j.mcat.2018.04.015

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title = "Deazaflavins as photocatalysts for the direct reductive regeneration of flavoenzymes",

abstract = "Deazaflavins are potentially useful redox mediators for the direct, nicotinamide-independent regeneration of oxidoreductases. Especially the O2-stability of their reduced forms have attracted significant interest for the regeneration of monooxygenases. In this contribution we further investigate the photochemical properties of deazaflavins and investigate the scope and limitations of deazaflavin-based photoenzymatic reaction systems.",

keywords = "Biocatalysis, Flavin, Old yellow enzyme, Oxygen dilemma, Photochemistry",

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language = "English",

volume = "452",

pages = "277--283",

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AU - van Schie, M. M.C.H.

AU - Younes, S. H.H.

AU - Rauch, M. C.R.

AU - Pesic, M.

AU - Paul, C. E.

AU - Arends, I. W.C.E.

AU - Hollmann, F.

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PY - 2018

Y1 - 2018

N2 - Deazaflavins are potentially useful redox mediators for the direct, nicotinamide-independent regeneration of oxidoreductases. Especially the O2-stability of their reduced forms have attracted significant interest for the regeneration of monooxygenases. In this contribution we further investigate the photochemical properties of deazaflavins and investigate the scope and limitations of deazaflavin-based photoenzymatic reaction systems.

AB - Deazaflavins are potentially useful redox mediators for the direct, nicotinamide-independent regeneration of oxidoreductases. Especially the O2-stability of their reduced forms have attracted significant interest for the regeneration of monooxygenases. In this contribution we further investigate the photochemical properties of deazaflavins and investigate the scope and limitations of deazaflavin-based photoenzymatic reaction systems.

KW - Biocatalysis

KW - Flavin

KW - Old yellow enzyme

KW - Oxygen dilemma

KW - Photochemistry

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EP - 283

JO - Molecular Catalysis

JF - Molecular Catalysis

ER -

Deazaflavins as photocatalysts for the direct reductive regeneration of flavoenzymes

Abstract

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Keywords

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