Design and Custom Fabrication of a Smart Temperature Sensor for an Organ-on-a-chip Platform

Ronaldo Ponte; Vasiliki Giagka; Wouter A. Serdijn

doi:10.1109/BIOCAS.2018.8584834

Design and Custom Fabrication of a Smart Temperature Sensor for an Organ-on-a-chip Platform

Ronaldo Ponte, Vasiliki Giagka, Wouter A. Serdijn

Bio-Electronics

Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review

3 Citations (Scopus)

45 Downloads (Pure)

Abstract

This paper reports on the design and fabrication of a time-mode signal-processing in situ temperature sensor customized for an organ-on-a-chip (OOC) application. The circuit was fabricated using an in-house integrated circuit (IC) technology that requires only seven lithographic steps and is compatible with MEMS fabrication process. The proposed circuit is developed to provide the first out-of-incubator temperature monitoring of cell cultures on an OOC platform in a monolithic fabrication. Measurement results on wafer reveal a temperature measurement resolution of less than ±0.2 °C (3σ) and a maximum nonlinearity error of less than 0.3% across a temperature range from 25 °C to 100 °C.

Original language	English
Title of host publication	2018 IEEE Biomedical Circuits and Systems Conference (BioCAS)
Place of Publication	Piscataway, NJ
Publisher	IEEE
Pages	1-4
Number of pages	4
ISBN (Electronic)	978-1-5386-3603-9
ISBN (Print)	978-1-5386-3604-6
DOIs	https://doi.org/10.1109/BIOCAS.2018.8584834
Publication status	Published - 2018
Event	2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Cleveland, United States Duration: 17 Oct 2018 → 19 Oct 2018

Conference

Conference	2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018
Country/Territory	United States
City	Cleveland
Period	17/10/18 → 19/10/18

Bibliographical note

Accepted author manuscript

Keywords

IC MEMS co-design
Organ-on-a-chip
Smart temperature sensor
Time-mode signal-processing

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10.1109/BIOCAS.2018.8584834

biocas_2018Accepted author manuscript, 496 KB

Cite this

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title = "Design and Custom Fabrication of a Smart Temperature Sensor for an Organ-on-a-chip Platform",

abstract = "This paper reports on the design and fabrication of a time-mode signal-processing in situ temperature sensor customized for an organ-on-a-chip (OOC) application. The circuit was fabricated using an in-house integrated circuit (IC) technology that requires only seven lithographic steps and is compatible with MEMS fabrication process. The proposed circuit is developed to provide the first out-of-incubator temperature monitoring of cell cultures on an OOC platform in a monolithic fabrication. Measurement results on wafer reveal a temperature measurement resolution of less than ±0.2 °C (3σ) and a maximum nonlinearity error of less than 0.3% across a temperature range from 25 °C to 100 °C.",

keywords = "IC MEMS co-design, Organ-on-a-chip, Smart temperature sensor, Time-mode signal-processing",

author = "Ronaldo Ponte and Vasiliki Giagka and Serdijn, {Wouter A.}",

note = "Accepted author manuscript; 2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 ; Conference date: 17-10-2018 Through 19-10-2018",

year = "2018",

doi = "10.1109/BIOCAS.2018.8584834",

language = "English",

isbn = "978-1-5386-3604-6 ",

pages = "1--4",

booktitle = "2018 IEEE Biomedical Circuits and Systems Conference (BioCAS)",

publisher = "IEEE",

address = "United States",

}

Ponte, R , Giagka, V & Serdijn, WA 2018, Design and Custom Fabrication of a Smart Temperature Sensor for an Organ-on-a-chip Platform. in 2018 IEEE Biomedical Circuits and Systems Conference (BioCAS) ., 8584834, IEEE, Piscataway, NJ, pp. 1-4, 2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018, Cleveland, United States, 17/10/18. https://doi.org/10.1109/BIOCAS.2018.8584834

Design and Custom Fabrication of a Smart Temperature Sensor for an Organ-on-a-chip Platform. / Ponte, Ronaldo ; Giagka, Vasiliki ; Serdijn, Wouter A.
2018 IEEE Biomedical Circuits and Systems Conference (BioCAS) . Piscataway, NJ: IEEE, 2018. p. 1-4 8584834.

Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review

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T1 - Design and Custom Fabrication of a Smart Temperature Sensor for an Organ-on-a-chip Platform

AU - Ponte, Ronaldo

AU - Giagka, Vasiliki

AU - Serdijn, Wouter A.

N1 - Accepted author manuscript

PY - 2018

Y1 - 2018

N2 - This paper reports on the design and fabrication of a time-mode signal-processing in situ temperature sensor customized for an organ-on-a-chip (OOC) application. The circuit was fabricated using an in-house integrated circuit (IC) technology that requires only seven lithographic steps and is compatible with MEMS fabrication process. The proposed circuit is developed to provide the first out-of-incubator temperature monitoring of cell cultures on an OOC platform in a monolithic fabrication. Measurement results on wafer reveal a temperature measurement resolution of less than ±0.2 °C (3σ) and a maximum nonlinearity error of less than 0.3% across a temperature range from 25 °C to 100 °C.

AB - This paper reports on the design and fabrication of a time-mode signal-processing in situ temperature sensor customized for an organ-on-a-chip (OOC) application. The circuit was fabricated using an in-house integrated circuit (IC) technology that requires only seven lithographic steps and is compatible with MEMS fabrication process. The proposed circuit is developed to provide the first out-of-incubator temperature monitoring of cell cultures on an OOC platform in a monolithic fabrication. Measurement results on wafer reveal a temperature measurement resolution of less than ±0.2 °C (3σ) and a maximum nonlinearity error of less than 0.3% across a temperature range from 25 °C to 100 °C.

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KW - Organ-on-a-chip

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KW - Time-mode signal-processing

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DO - 10.1109/BIOCAS.2018.8584834

M3 - Conference contribution

AN - SCOPUS:85060886772

SN - 978-1-5386-3604-6

SP - 1

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BT - 2018 IEEE Biomedical Circuits and Systems Conference (BioCAS)

PB - IEEE

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T2 - 2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018

Y2 - 17 October 2018 through 19 October 2018

ER -

Design and Custom Fabrication of a Smart Temperature Sensor for an Organ-on-a-chip Platform

Abstract

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Keywords

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