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Determinants of carotid atherosclerotic plaque burden in a stroke-free population. / Selwaness, Mariana; Hameeteman, Reinhard; Van 't Klooster, Ronald; Van den Bouwhuijsen, Quirijn; Hofman, Albert; Franco, Oscar H.; Niessen, Wiro J.; Klein, Stefan; Vernooij, Meike W.; Van der Lugt, Aad; Wentzel, Jolanda J.

In: Atherosclerosis, Vol. 255, 01.12.2016, p. 186-192.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Selwaness, M, Hameeteman, R, Van 't Klooster, R, Van den Bouwhuijsen, Q, Hofman, A, Franco, OH, Niessen, WJ, Klein, S, Vernooij, MW, Van der Lugt, A & Wentzel, JJ 2016, 'Determinants of carotid atherosclerotic plaque burden in a stroke-free population' Atherosclerosis, vol. 255, pp. 186-192. https://doi.org/10.1016/j.atherosclerosis.2016.10.030

APA

Selwaness, M., Hameeteman, R., Van 't Klooster, R., Van den Bouwhuijsen, Q., Hofman, A., Franco, O. H., ... Wentzel, J. J. (2016). Determinants of carotid atherosclerotic plaque burden in a stroke-free population. Atherosclerosis, 255, 186-192. https://doi.org/10.1016/j.atherosclerosis.2016.10.030

Vancouver

Selwaness M, Hameeteman R, Van 't Klooster R, Van den Bouwhuijsen Q, Hofman A, Franco OH et al. Determinants of carotid atherosclerotic plaque burden in a stroke-free population. Atherosclerosis. 2016 Dec 1;255:186-192. https://doi.org/10.1016/j.atherosclerosis.2016.10.030

Author

Selwaness, Mariana ; Hameeteman, Reinhard ; Van 't Klooster, Ronald ; Van den Bouwhuijsen, Quirijn ; Hofman, Albert ; Franco, Oscar H. ; Niessen, Wiro J. ; Klein, Stefan ; Vernooij, Meike W. ; Van der Lugt, Aad ; Wentzel, Jolanda J. / Determinants of carotid atherosclerotic plaque burden in a stroke-free population. In: Atherosclerosis. 2016 ; Vol. 255. pp. 186-192.

BibTeX

@article{2f09d5f31d854566aa490e390d0866a1,
title = "Determinants of carotid atherosclerotic plaque burden in a stroke-free population",
abstract = "Background and aims In a large stroke-free population, we sought to identify cardiovascular risk factors and carotid plaque components associated with carotid plaque burden, lumen volume and stenosis. Methods The carotid arteries of 1562 stroke-free participants from The Rotterdam Study were imaged on a 1.5-Tesla MRI scanner. Inner and outer wall of the carotid arteries were automatically segmented and lumen volume (mm3), wall volume (outer wall–inner wall) and plaque burden (wall volume/outer wall volume) ({\%}) were quantified. Plaque components were visually determined and luminal stenosis was assessed. We analyzed associations of cardiovascular risk factors and carotid plaque components with plaque burden and lumen volumes using regression analysis. Results We investigated 2821 carotid plaques and found that women had larger plaque burden (50.7 ± 7.8{\%} vs. 49.2 ± 7.7{\%}, p <0.0001) and smaller lumen volumes (933 ± 286 mm3 vs. 1078 ± 334 mm3, p <0.0001) than men. In women, age, HDL-cholesterol and systolic blood pressure, and in men, total cholesterol, non-HDL cholesterol and statin use were independently associated with higher plaque burden and lumen volume. Furthermore, smoking and diabetes were associated with lumen volume in men (respectively p = 0.04 and p = 0.002). Intraplaque hemorrhage (IPH) and lipid were related to a larger plaque burden (OR 1.30 [1.05–1.60] and OR 1.28[1.06–1.55]). Finally, within the highest quartile of plaque burden, IPH was strongly associated with luminal stenosis independent of age, sex, plaque burden and composition (Beta = 15.2; [11.8–18.6]). Conclusions Several cardiovascular risk factors and plaque components, in particular IPH, are associated with higher plaque burden. Carotid IPH is strongly associated with an increased luminal stenosis.",
keywords = "Atherosclerosis, Automated segmentation, Carotid artery, Magnetic resonance imaging, Plaque burden, Plaque volume",
author = "Mariana Selwaness and Reinhard Hameeteman and {Van 't Klooster}, Ronald and {Van den Bouwhuijsen}, Quirijn and Albert Hofman and Franco, {Oscar H.} and Niessen, {Wiro J.} and Stefan Klein and Vernooij, {Meike W.} and {Van der Lugt}, Aad and Wentzel, {Jolanda J.}",
year = "2016",
month = "12",
day = "1",
doi = "10.1016/j.atherosclerosis.2016.10.030",
language = "English",
volume = "255",
pages = "186--192",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Determinants of carotid atherosclerotic plaque burden in a stroke-free population

AU - Selwaness, Mariana

AU - Hameeteman, Reinhard

AU - Van 't Klooster, Ronald

AU - Van den Bouwhuijsen, Quirijn

AU - Hofman, Albert

AU - Franco, Oscar H.

AU - Niessen, Wiro J.

AU - Klein, Stefan

AU - Vernooij, Meike W.

AU - Van der Lugt, Aad

AU - Wentzel, Jolanda J.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background and aims In a large stroke-free population, we sought to identify cardiovascular risk factors and carotid plaque components associated with carotid plaque burden, lumen volume and stenosis. Methods The carotid arteries of 1562 stroke-free participants from The Rotterdam Study were imaged on a 1.5-Tesla MRI scanner. Inner and outer wall of the carotid arteries were automatically segmented and lumen volume (mm3), wall volume (outer wall–inner wall) and plaque burden (wall volume/outer wall volume) (%) were quantified. Plaque components were visually determined and luminal stenosis was assessed. We analyzed associations of cardiovascular risk factors and carotid plaque components with plaque burden and lumen volumes using regression analysis. Results We investigated 2821 carotid plaques and found that women had larger plaque burden (50.7 ± 7.8% vs. 49.2 ± 7.7%, p <0.0001) and smaller lumen volumes (933 ± 286 mm3 vs. 1078 ± 334 mm3, p <0.0001) than men. In women, age, HDL-cholesterol and systolic blood pressure, and in men, total cholesterol, non-HDL cholesterol and statin use were independently associated with higher plaque burden and lumen volume. Furthermore, smoking and diabetes were associated with lumen volume in men (respectively p = 0.04 and p = 0.002). Intraplaque hemorrhage (IPH) and lipid were related to a larger plaque burden (OR 1.30 [1.05–1.60] and OR 1.28[1.06–1.55]). Finally, within the highest quartile of plaque burden, IPH was strongly associated with luminal stenosis independent of age, sex, plaque burden and composition (Beta = 15.2; [11.8–18.6]). Conclusions Several cardiovascular risk factors and plaque components, in particular IPH, are associated with higher plaque burden. Carotid IPH is strongly associated with an increased luminal stenosis.

AB - Background and aims In a large stroke-free population, we sought to identify cardiovascular risk factors and carotid plaque components associated with carotid plaque burden, lumen volume and stenosis. Methods The carotid arteries of 1562 stroke-free participants from The Rotterdam Study were imaged on a 1.5-Tesla MRI scanner. Inner and outer wall of the carotid arteries were automatically segmented and lumen volume (mm3), wall volume (outer wall–inner wall) and plaque burden (wall volume/outer wall volume) (%) were quantified. Plaque components were visually determined and luminal stenosis was assessed. We analyzed associations of cardiovascular risk factors and carotid plaque components with plaque burden and lumen volumes using regression analysis. Results We investigated 2821 carotid plaques and found that women had larger plaque burden (50.7 ± 7.8% vs. 49.2 ± 7.7%, p <0.0001) and smaller lumen volumes (933 ± 286 mm3 vs. 1078 ± 334 mm3, p <0.0001) than men. In women, age, HDL-cholesterol and systolic blood pressure, and in men, total cholesterol, non-HDL cholesterol and statin use were independently associated with higher plaque burden and lumen volume. Furthermore, smoking and diabetes were associated with lumen volume in men (respectively p = 0.04 and p = 0.002). Intraplaque hemorrhage (IPH) and lipid were related to a larger plaque burden (OR 1.30 [1.05–1.60] and OR 1.28[1.06–1.55]). Finally, within the highest quartile of plaque burden, IPH was strongly associated with luminal stenosis independent of age, sex, plaque burden and composition (Beta = 15.2; [11.8–18.6]). Conclusions Several cardiovascular risk factors and plaque components, in particular IPH, are associated with higher plaque burden. Carotid IPH is strongly associated with an increased luminal stenosis.

KW - Atherosclerosis

KW - Automated segmentation

KW - Carotid artery

KW - Magnetic resonance imaging

KW - Plaque burden

KW - Plaque volume

UR - http://resolver.tudelft.nl/uuid:2f09d5f3-1d85-4566-aa49-0e390d0866a1

UR - http://www.scopus.com/inward/record.url?scp=85000788475&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2016.10.030

DO - 10.1016/j.atherosclerosis.2016.10.030

M3 - Article

VL - 255

SP - 186

EP - 192

JO - Atherosclerosis

T2 - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

ER -

ID: 9625801