TY - JOUR
T1 - Direct preparation of drug-loaded mesoporous silica nanoparticles by sequential flash nanoprecipitation
AU - Fu, Zhinan
AU - Li, Li
AU - Wang, Yiming
AU - Chen, Qiaolin
AU - Zhao, Fang
AU - Dai, Liheng
AU - Chen, Zhuo
AU - Liu, Dianhua
AU - Guo, Xuhong
PY - 2020
Y1 - 2020
N2 - The present work demonstrates how drug-loaded mesoporous silica nanoparticles (MSNPs) can be prepared by a sequential flash nanoprecipitation (FNP) technique. A sequential FNP technique is developed relying on a combination of two multi-inlet vortex mixers (MIVM), by which a continuous process that involves the formation of micelle-based templates followed by an in situ formation of MSNPs is achieved. Moreover, a widely used biological nematicide, abamectin (Abm), is added during the formation of micelles, ultimately leading to Abm-loaded MSNPs with high encapsulation efficiency. The obtained Abm-loaded MSNPs show excellent stability and inhibition activity against the livability of Meloidogyne incognita. Importantly, the parameters of the resulting MSNPs, such as silica shell thickness and inner cavity size of MSNPs, can be easily controlled by tuning the compositions of the reactant streams. We believe that such a simple approach towards direct preparation of drug-loaded MSNPs would find promising up-scale applications in various fields, such as drug delivery, bioimaging, and formulation technology.
AB - The present work demonstrates how drug-loaded mesoporous silica nanoparticles (MSNPs) can be prepared by a sequential flash nanoprecipitation (FNP) technique. A sequential FNP technique is developed relying on a combination of two multi-inlet vortex mixers (MIVM), by which a continuous process that involves the formation of micelle-based templates followed by an in situ formation of MSNPs is achieved. Moreover, a widely used biological nematicide, abamectin (Abm), is added during the formation of micelles, ultimately leading to Abm-loaded MSNPs with high encapsulation efficiency. The obtained Abm-loaded MSNPs show excellent stability and inhibition activity against the livability of Meloidogyne incognita. Importantly, the parameters of the resulting MSNPs, such as silica shell thickness and inner cavity size of MSNPs, can be easily controlled by tuning the compositions of the reactant streams. We believe that such a simple approach towards direct preparation of drug-loaded MSNPs would find promising up-scale applications in various fields, such as drug delivery, bioimaging, and formulation technology.
KW - Abamectin
KW - Drug delivery
KW - Mesoporous silica nanoparticles
KW - Sequential flash nanoprecipitation
UR - http://www.scopus.com/inward/record.url?scp=85072828639&partnerID=8YFLogxK
U2 - 10.1016/j.cej.2019.122905
DO - 10.1016/j.cej.2019.122905
M3 - Article
AN - SCOPUS:85072828639
SN - 1385-8947
VL - 382
JO - Chemical Engineering Journal
JF - Chemical Engineering Journal
M1 - 122905
ER -