TY - JOUR
T1 - Efficient and Practical Transfer Hydrogenation of Ketones Catalyzed by a Simple Bidentate Mn−NHC Complex
AU - van Putten, Robbert
AU - Benschop, Joeri
AU - de Munck, Vincent J.
AU - Weber, Manuela
AU - Müller, Christian
AU - Filonenko, Georgy A.
AU - Pidko, Evgeny A.
N1 - Accepted Author Manuscript
PY - 2019
Y1 - 2019
N2 - Catalytic reductions of carbonyl-containing compounds are highly important for the safe, sustainable, and economical production of alcohols. Herein, we report on the efficient transfer hydrogenation of ketones catalyzed by a highly potent Mn(I)−NHC complex. Mn−NHC 1 is practical at metal concentrations as low as 75 ppm, thus approaching loadings more conventionally reserved for noble metal based systems. With these low Mn concentrations, catalyst deactivation is found to be highly temperature dependent and becomes especially prominent at increased reaction temperature. Ultimately, understanding of deactivation pathways could help close the activity/stability-gap with Ru and Ir catalysts towards the practical implementation of sustainable earth-abundant Mn-complexes.
AB - Catalytic reductions of carbonyl-containing compounds are highly important for the safe, sustainable, and economical production of alcohols. Herein, we report on the efficient transfer hydrogenation of ketones catalyzed by a highly potent Mn(I)−NHC complex. Mn−NHC 1 is practical at metal concentrations as low as 75 ppm, thus approaching loadings more conventionally reserved for noble metal based systems. With these low Mn concentrations, catalyst deactivation is found to be highly temperature dependent and becomes especially prominent at increased reaction temperature. Ultimately, understanding of deactivation pathways could help close the activity/stability-gap with Ru and Ir catalysts towards the practical implementation of sustainable earth-abundant Mn-complexes.
KW - Alcohols
KW - Ketones
KW - Manganese
KW - N-Heterocyclic Carbene
KW - Transfer Hydrogenation
UR - http://www.scopus.com/inward/record.url?scp=85068891911&partnerID=8YFLogxK
U2 - 10.1002/cctc.201900882
DO - 10.1002/cctc.201900882
M3 - Article
AN - SCOPUS:85068891911
SN - 1867-3880
VL - 11
JO - ChemCatChem
JF - ChemCatChem
IS - 21
ER -