FOx News: Towards Methanol-driven Biocatalytic Oxyfunctionalisation Reactions

Sébastien J.P. Willot; Manh Dat Hoang; Caroline E. Paul; Miguel Alcalde; Isabel W.C.E. Arends; Andreas S. Bommarius; Bettina Bommarius; Frank Hollmann

doi:10.1002/cctc.202000197

FOx News: Towards Methanol-driven Biocatalytic Oxyfunctionalisation Reactions

Sébastien J.P. Willot, Manh Dat Hoang, Caroline E. Paul, Miguel Alcalde, Isabel W.C.E. Arends, Andreas S. Bommarius, Bettina Bommarius, Frank Hollmann^*

^*Corresponding author for this work

BT/Biocatalysis

Research output: Contribution to journal › Article › Scientific › peer-review

14 Citations (Scopus)

61 Downloads (Pure)

Abstract

The novel formate oxidase from Aspergillus oryzae (AoFOx) is a useful catalyst to promote H₂O₂-dependent oxyfunctionalisation reactions. In this contribution we exploit the substrate promiscuity of AoFOx to fully oxidise methanol and formaldehyde to CO₂ and drive peroxygenase-catalysed stereoselective oxyfunctionalisation reactions. The highly atom efficient H₂O₂ generation system also enabled high catalytic turnover of the peroxygenase production enzyme.

Original language	English
Pages (from-to)	2713-2716
Number of pages	5
Journal	ChemCatChem
Volume	12
Issue number	10
DOIs	https://doi.org/10.1002/cctc.202000197
Publication status	Published - 2020

Keywords

Biocatalysis
Formate oxidase
Methanol
Oxyfunctionalisation
Peroxygenases

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cctc.202000197Final published version, 905 KBLicence: CC BY

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title = "FOx News: Towards Methanol-driven Biocatalytic Oxyfunctionalisation Reactions",

abstract = "The novel formate oxidase from Aspergillus oryzae (AoFOx) is a useful catalyst to promote H2O2-dependent oxyfunctionalisation reactions. In this contribution we exploit the substrate promiscuity of AoFOx to fully oxidise methanol and formaldehyde to CO2 and drive peroxygenase-catalysed stereoselective oxyfunctionalisation reactions. The highly atom efficient H2O2 generation system also enabled high catalytic turnover of the peroxygenase production enzyme.",

keywords = "Biocatalysis, Formate oxidase, Methanol, Oxyfunctionalisation, Peroxygenases",

author = "Willot, {S{\'e}bastien J.P.} and Hoang, {Manh Dat} and Paul, {Caroline E.} and Miguel Alcalde and Arends, {Isabel W.C.E.} and Bommarius, {Andreas S.} and Bettina Bommarius and Frank Hollmann",

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AU - Willot, Sébastien J.P.

AU - Hoang, Manh Dat

AU - Paul, Caroline E.

AU - Alcalde, Miguel

AU - Arends, Isabel W.C.E.

AU - Bommarius, Andreas S.

AU - Bommarius, Bettina

AU - Hollmann, Frank

PY - 2020

Y1 - 2020

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AB - The novel formate oxidase from Aspergillus oryzae (AoFOx) is a useful catalyst to promote H2O2-dependent oxyfunctionalisation reactions. In this contribution we exploit the substrate promiscuity of AoFOx to fully oxidise methanol and formaldehyde to CO2 and drive peroxygenase-catalysed stereoselective oxyfunctionalisation reactions. The highly atom efficient H2O2 generation system also enabled high catalytic turnover of the peroxygenase production enzyme.

KW - Biocatalysis

KW - Formate oxidase

KW - Methanol

KW - Oxyfunctionalisation

KW - Peroxygenases

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VL - 12

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EP - 2716

JO - ChemCatChem

JF - ChemCatChem

IS - 10

ER -

FOx News: Towards Methanol-driven Biocatalytic Oxyfunctionalisation Reactions

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Keywords

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