We present the largest population-based heritability study of the human brain structural connectome, including a pathology-sensitive extension, the disconnectome. The disconnectome maps the effect of white matter lesions throughout the brain. The connectome and disconnectome were generated from diffusion-weighted images of 3255 unrelated subjects from the Rotterdam Study aged between 45 and 99 years. Graph theory measures were derived for both the connectome and disconnectome. Genotypes were used to derive genetic relationship matrices between individuals for heritability analyses. High measures of heritability, from 33% to 51%, were found across all connectivity measures. The disconnectome showed more significantly heritable connectivity measures than the connectome, suggesting that the new proposed measure may reveal additional or complementary information about the genetic architecture of the human brain.

Original languageEnglish
Title of host publicationProceedings of IEEE 14th International Symposium on Biomedical Imaging, ISBI 2017
PublisherIEEE Computer Society
Pages349-353
Number of pages5
ISBN (Electronic)9781509011711
DOIs
Publication statusPublished - 15 Jun 2017
Event14th IEEE International Symposium on Biomedical Imaging, ISBI 2017 - Melbourne, Australia
Duration: 18 Apr 201721 Apr 2017

Conference

Conference14th IEEE International Symposium on Biomedical Imaging, ISBI 2017
CountryAustralia
CityMelbourne
Period18/04/1721/04/17

    Research areas

  • Brain, Connectivity, Genetics, Heritability

ID: 33425018