High Frequency Functional Ultrasound in Mice

S. K.E. Koekkoek; S. Soloukeytbalvandany; B. S. Generowicz; W. S. Vanhoogstraten; N. L. Deoude; H. J. Boele; C. Strydis; G. Leus; C. I. De Zeeuw; null More Authors

doi:10.1109/ULTSYM.2018.8579865

High Frequency Functional Ultrasound in Mice

S. K.E. Koekkoek, S. Soloukeytbalvandany, B. S. Generowicz, W. S. Vanhoogstraten, N. L. Deoude, H. J. Boele, C. Strydis, G. Leus, C. I. De Zeeuw, More Authors

Signal Processing Systems

Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review

6 Citations (Scopus)

17 Downloads (Pure)

Abstract

Functional ultrasound (fUS) is a relatively new imaging modality to study the brain with a high spatiotemporal resolution and a wide field-of-view. In fUS detailed images of cerebral blood flow and volume are used to derive functional information, as changes in local flow and/or volume may reflect neuronal activation through neurovascular coupling. Most fUS studies so far have been performed in rats. Translating fUS to mice, which is a favorable animal model for neuroscience, pleads for a higher spatial resolution than what has been reported so far. As a consequence the temporal sampling of the blood flow should also be increased in order to adequately capture the wide range in blood velocities, as the Doppler shifts are inversely proportional to the spatial resolution. Here we present our first detailed images of the mouse brain vasculature at high spatiotemporal resolution. In addition we show some early experimental work on tracking brain activity upon local electrical stimulation.

Original language	English
Title of host publication	2018 IEEE International Ultrasonics Symposium, IUS 2018
Editors	Ken-ya Hashimoto , Clemens Ruppel
Publisher	IEEE
Number of pages	4
Volume	2018-October
ISBN (Electronic)	978-153863425-7
DOIs	https://doi.org/10.1109/ULTSYM.2018.8579865
Publication status	Published - 2018
Event	2018 IEEE International Ultrasonics Symposium, IUS 2018 - Portopia Hotel, Kobe, Japan Duration: 22 Oct 2018 → 25 Oct 2018

Conference

Conference	2018 IEEE International Ultrasonics Symposium, IUS 2018
Abbreviated title	IUS 2018
Country/Territory	Japan
City	Kobe
Period	22/10/18 → 25/10/18

Bibliographical note

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care
Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

Keywords

fUS
high frequency
mice brain
μDoppler

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10.1109/ULTSYM.2018.8579865

High_Frequency_Functional_Ultrasound_in_MiceFinal published version, 528 KB

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Koekkoek, S. K. E., Soloukeytbalvandany, S., Generowicz, B. S., Vanhoogstraten, W. S., Deoude, N. L., Boele, H. J., Strydis, C., Leus, G., De Zeeuw, C. I., & More Authors (2018). High Frequency Functional Ultrasound in Mice. In K. Hashimoto , & C. Ruppel (Eds.), 2018 IEEE International Ultrasonics Symposium, IUS 2018 (Vol. 2018-October). Article 8579865 IEEE. https://doi.org/10.1109/ULTSYM.2018.8579865

@inproceedings{4d79330b62974734b381d611c9387327,

title = "High Frequency Functional Ultrasound in Mice",

abstract = "Functional ultrasound (fUS) is a relatively new imaging modality to study the brain with a high spatiotemporal resolution and a wide field-of-view. In fUS detailed images of cerebral blood flow and volume are used to derive functional information, as changes in local flow and/or volume may reflect neuronal activation through neurovascular coupling. Most fUS studies so far have been performed in rats. Translating fUS to mice, which is a favorable animal model for neuroscience, pleads for a higher spatial resolution than what has been reported so far. As a consequence the temporal sampling of the blood flow should also be increased in order to adequately capture the wide range in blood velocities, as the Doppler shifts are inversely proportional to the spatial resolution. Here we present our first detailed images of the mouse brain vasculature at high spatiotemporal resolution. In addition we show some early experimental work on tracking brain activity upon local electrical stimulation.",

keywords = "fUS, high frequency, mice brain, μDoppler",

author = "Koekkoek, {S. K.E.} and S. Soloukeytbalvandany and Generowicz, {B. S.} and Vanhoogstraten, {W. S.} and Deoude, {N. L.} and Boele, {H. J.} and C. Strydis and G. Leus and {De Zeeuw}, {C. I.} and {More Authors}",

note = "Green Open Access added to TU Delft Institutional Repository {\textquoteleft}You share, we take care!{\textquoteright} – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.; 2018 IEEE International Ultrasonics Symposium, IUS 2018, IUS 2018 ; Conference date: 22-10-2018 Through 25-10-2018",

year = "2018",

doi = "10.1109/ULTSYM.2018.8579865",

language = "English",

volume = "2018-October",

editor = "{Hashimoto }, {Ken-ya } and Ruppel, {Clemens }",

booktitle = "2018 IEEE International Ultrasonics Symposium, IUS 2018",

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address = "United States",

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Koekkoek, SKE, Soloukeytbalvandany, S, Generowicz, BS, Vanhoogstraten, WS, Deoude, NL, Boele, HJ, Strydis, C, Leus, G, De Zeeuw, CI & More Authors 2018, High Frequency Functional Ultrasound in Mice. in K Hashimoto & C Ruppel (eds), 2018 IEEE International Ultrasonics Symposium, IUS 2018. vol. 2018-October, 8579865, IEEE, 2018 IEEE International Ultrasonics Symposium, IUS 2018, Kobe, Japan, 22/10/18. https://doi.org/10.1109/ULTSYM.2018.8579865

High Frequency Functional Ultrasound in Mice. / Koekkoek, S. K.E.; Soloukeytbalvandany, S.; Generowicz, B. S. et al.
2018 IEEE International Ultrasonics Symposium, IUS 2018. ed. / Ken-ya Hashimoto ; Clemens Ruppel. Vol. 2018-October IEEE, 2018. 8579865.

Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review

TY - GEN

T1 - High Frequency Functional Ultrasound in Mice

AU - Koekkoek, S. K.E.

AU - Soloukeytbalvandany, S.

AU - Generowicz, B. S.

AU - Vanhoogstraten, W. S.

AU - Deoude, N. L.

AU - Boele, H. J.

AU - Strydis, C.

AU - Leus, G.

AU - De Zeeuw, C. I.

AU - More Authors, null

N1 - Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

PY - 2018

Y1 - 2018

N2 - Functional ultrasound (fUS) is a relatively new imaging modality to study the brain with a high spatiotemporal resolution and a wide field-of-view. In fUS detailed images of cerebral blood flow and volume are used to derive functional information, as changes in local flow and/or volume may reflect neuronal activation through neurovascular coupling. Most fUS studies so far have been performed in rats. Translating fUS to mice, which is a favorable animal model for neuroscience, pleads for a higher spatial resolution than what has been reported so far. As a consequence the temporal sampling of the blood flow should also be increased in order to adequately capture the wide range in blood velocities, as the Doppler shifts are inversely proportional to the spatial resolution. Here we present our first detailed images of the mouse brain vasculature at high spatiotemporal resolution. In addition we show some early experimental work on tracking brain activity upon local electrical stimulation.

AB - Functional ultrasound (fUS) is a relatively new imaging modality to study the brain with a high spatiotemporal resolution and a wide field-of-view. In fUS detailed images of cerebral blood flow and volume are used to derive functional information, as changes in local flow and/or volume may reflect neuronal activation through neurovascular coupling. Most fUS studies so far have been performed in rats. Translating fUS to mice, which is a favorable animal model for neuroscience, pleads for a higher spatial resolution than what has been reported so far. As a consequence the temporal sampling of the blood flow should also be increased in order to adequately capture the wide range in blood velocities, as the Doppler shifts are inversely proportional to the spatial resolution. Here we present our first detailed images of the mouse brain vasculature at high spatiotemporal resolution. In addition we show some early experimental work on tracking brain activity upon local electrical stimulation.

KW - fUS

KW - high frequency

KW - mice brain

KW - μDoppler

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U2 - 10.1109/ULTSYM.2018.8579865

DO - 10.1109/ULTSYM.2018.8579865

M3 - Conference contribution

AN - SCOPUS:85060583612

VL - 2018-October

BT - 2018 IEEE International Ultrasonics Symposium, IUS 2018

A2 - Hashimoto , Ken-ya

A2 - Ruppel, Clemens

PB - IEEE

T2 - 2018 IEEE International Ultrasonics Symposium, IUS 2018

Y2 - 22 October 2018 through 25 October 2018

ER -

High Frequency Functional Ultrasound in Mice

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Keywords

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