Large-scale production of lutetium-177m for the 177mLu/177Lu radionuclide generator

Rupali Bhardwaj; Bernard Ponsard; Mehmet Sarilar; Bert Wolterbeek; Antonia Denkova; Pablo Serra-Crespo

doi:10.1016/j.apradiso.2019.108986

Large-scale production of lutetium-177m for the ^177mLu/¹⁷⁷Lu radionuclide generator

Rupali Bhardwaj, Bernard Ponsard, Mehmet Sarilar, Bert Wolterbeek, Antonia Denkova, Pablo Serra-Crespo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

8 Citations (Scopus)

Abstract

In this work, ^177mLu has been produced by irradiation of natural Lu₂O₃ targets at the BR2 reactor (Mol, Belgium) and the obtained data together with literature values have been used to theoretically investigate the production of ^177mLu at different neutron fluxes, irradiation times and enrichment of ¹⁷⁶Lu. The irradiation time (t_max) needed to reach the maximum ^177mLu production has been found to change from 42, 12, 4 days with the increase in the thermal neutron flux from 2*10¹⁴, 8*10¹⁴, 2.5*10¹⁵ n cm⁻² s⁻¹, respectively while keeping the maximum ^177mLu activity unaffected. The results of our calculations suggest that 0.11 TBq ^177mLu with a specific activity of 0.3 TBq g⁻¹ Lu can be produced in a short irradiation time of 4 days using 1g of 84.44% ¹⁷⁶Lu enriched Lu₂O₃ and a thermal neutron flux of 2.5*10¹⁵ n cm⁻² s⁻¹.

Original language	English
Article number	108986
Number of pages	7
Journal	Applied Radiation and Isotopes
Volume	156
DOIs	https://doi.org/10.1016/j.apradiso.2019.108986
Publication status	Published - 2020

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10.1016/j.apradiso.2019.108986

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title = "Large-scale production of lutetium-177m for the 177mLu/177Lu radionuclide generator",

abstract = "In this work, 177mLu has been produced by irradiation of natural Lu2O3 targets at the BR2 reactor (Mol, Belgium) and the obtained data together with literature values have been used to theoretically investigate the production of 177mLu at different neutron fluxes, irradiation times and enrichment of 176Lu. The irradiation time (tmax) needed to reach the maximum 177mLu production has been found to change from 42, 12, 4 days with the increase in the thermal neutron flux from 2*1014, 8*1014, 2.5*1015 n cm−2 s−1, respectively while keeping the maximum 177mLu activity unaffected. The results of our calculations suggest that 0.11 TBq 177mLu with a specific activity of 0.3 TBq g−1 Lu can be produced in a short irradiation time of 4 days using 1g of 84.44% 176Lu enriched Lu2O3 and a thermal neutron flux of 2.5*1015 n cm−2 s−1.",

author = "Rupali Bhardwaj and Bernard Ponsard and Mehmet Sarilar and Bert Wolterbeek and Antonia Denkova and Pablo Serra-Crespo",

year = "2020",

doi = "10.1016/j.apradiso.2019.108986",

language = "English",

volume = "156",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier",

}

TY - JOUR

T1 - Large-scale production of lutetium-177m for the 177mLu/177Lu radionuclide generator

AU - Bhardwaj, Rupali

AU - Ponsard, Bernard

AU - Sarilar, Mehmet

AU - Wolterbeek, Bert

AU - Denkova, Antonia

AU - Serra-Crespo, Pablo

PY - 2020

Y1 - 2020

N2 - In this work, 177mLu has been produced by irradiation of natural Lu2O3 targets at the BR2 reactor (Mol, Belgium) and the obtained data together with literature values have been used to theoretically investigate the production of 177mLu at different neutron fluxes, irradiation times and enrichment of 176Lu. The irradiation time (tmax) needed to reach the maximum 177mLu production has been found to change from 42, 12, 4 days with the increase in the thermal neutron flux from 2*1014, 8*1014, 2.5*1015 n cm−2 s−1, respectively while keeping the maximum 177mLu activity unaffected. The results of our calculations suggest that 0.11 TBq 177mLu with a specific activity of 0.3 TBq g−1 Lu can be produced in a short irradiation time of 4 days using 1g of 84.44% 176Lu enriched Lu2O3 and a thermal neutron flux of 2.5*1015 n cm−2 s−1.

AB - In this work, 177mLu has been produced by irradiation of natural Lu2O3 targets at the BR2 reactor (Mol, Belgium) and the obtained data together with literature values have been used to theoretically investigate the production of 177mLu at different neutron fluxes, irradiation times and enrichment of 176Lu. The irradiation time (tmax) needed to reach the maximum 177mLu production has been found to change from 42, 12, 4 days with the increase in the thermal neutron flux from 2*1014, 8*1014, 2.5*1015 n cm−2 s−1, respectively while keeping the maximum 177mLu activity unaffected. The results of our calculations suggest that 0.11 TBq 177mLu with a specific activity of 0.3 TBq g−1 Lu can be produced in a short irradiation time of 4 days using 1g of 84.44% 176Lu enriched Lu2O3 and a thermal neutron flux of 2.5*1015 n cm−2 s−1.

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DO - 10.1016/j.apradiso.2019.108986

M3 - Article

C2 - 31786419

SN - 0969-8043

VL - 156

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

M1 - 108986

ER -

Large-scale production of lutetium-177m for the ^177mLu/¹⁷⁷Lu radionuclide generator

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