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Markers of cerebral small vessel disease and severity of depression in the general population. / Direk, Nese; Perez, Heidi Saavedra; Akoudad, Saloua; Verhaaren, Benjamin F J; Niessen, Wiro J.; Hofman, Albert; Vernooij, Meike W.; Ikram, M. Arfan; Tiemeier, Henning.

In: Psychiatry Research - Neuroimaging, Vol. 253, 30.07.2016, p. 1-6.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Direk, N, Perez, HS, Akoudad, S, Verhaaren, BFJ, Niessen, WJ, Hofman, A, Vernooij, MW, Ikram, MA & Tiemeier, H 2016, 'Markers of cerebral small vessel disease and severity of depression in the general population' Psychiatry Research - Neuroimaging, vol. 253, pp. 1-6. https://doi.org/10.1016/j.pscychresns.2016.05.002

APA

Direk, N., Perez, H. S., Akoudad, S., Verhaaren, B. F. J., Niessen, W. J., Hofman, A., ... Tiemeier, H. (2016). Markers of cerebral small vessel disease and severity of depression in the general population. Psychiatry Research - Neuroimaging, 253, 1-6. https://doi.org/10.1016/j.pscychresns.2016.05.002

Vancouver

Direk N, Perez HS, Akoudad S, Verhaaren BFJ, Niessen WJ, Hofman A et al. Markers of cerebral small vessel disease and severity of depression in the general population. Psychiatry Research - Neuroimaging. 2016 Jul 30;253:1-6. https://doi.org/10.1016/j.pscychresns.2016.05.002

Author

Direk, Nese ; Perez, Heidi Saavedra ; Akoudad, Saloua ; Verhaaren, Benjamin F J ; Niessen, Wiro J. ; Hofman, Albert ; Vernooij, Meike W. ; Ikram, M. Arfan ; Tiemeier, Henning. / Markers of cerebral small vessel disease and severity of depression in the general population. In: Psychiatry Research - Neuroimaging. 2016 ; Vol. 253. pp. 1-6.

BibTeX

@article{91b6cc7fc9a74f399652cb3789176e05,
title = "Markers of cerebral small vessel disease and severity of depression in the general population",
abstract = "The vascular depression hypothesis postulates that cerebral small vessel disease can cause or exacerbate depression in elderly persons. Numerous studies explored the association of imaging markers of cerebral small vessel disease including white matter lesions (WMLs) and lacunar infarcts with depressive symptoms or disorders. However, cerebral microbleeds have not been tested in depression. In the current study, we aimed to explore the association of WMLs, lacunar infarcts and cerebral microbleeds with depression continuum in a large population-based sample, the Rotterdam Study. Study population consisted of 3799 participants (aged 45 or over) free of dementia. WML volumes, lacunar infarcts and cerebral microbleeds were measured with brain magnetic resonance imaging. Depressive symptoms, depressive disorders and co-morbid anxiety disorders were assessed with validated questionnaires and clinical interview. WML volumes and lacunar infarcts were associated with depressive symptoms and disorders. Cerebral microbleeds, especially in deep or infratentorial brain regions, were related to depressive disorders only. Our results indicate that WMLs and lacunar infarcts might be non-specific vascular lesions seen in depressive symptoms and disorders. Association of cerebral microbleeds with more severe forms of depression may indicate impaired brain iron homeostasis or minor episodes of cerebrovascular extraversion, which may play a role in depression etiology.",
keywords = "Anxiety, Cerebral microbleeds, Depressive iisorders, Depressive symptoms, Lacunar infracts, Vascular depression, White matter lesions",
author = "Nese Direk and Perez, {Heidi Saavedra} and Saloua Akoudad and Verhaaren, {Benjamin F J} and Niessen, {Wiro J.} and Albert Hofman and Vernooij, {Meike W.} and Ikram, {M. Arfan} and Henning Tiemeier",
year = "2016",
month = "7",
day = "30",
doi = "10.1016/j.pscychresns.2016.05.002",
language = "English",
volume = "253",
pages = "1--6",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Markers of cerebral small vessel disease and severity of depression in the general population

AU - Direk, Nese

AU - Perez, Heidi Saavedra

AU - Akoudad, Saloua

AU - Verhaaren, Benjamin F J

AU - Niessen, Wiro J.

AU - Hofman, Albert

AU - Vernooij, Meike W.

AU - Ikram, M. Arfan

AU - Tiemeier, Henning

PY - 2016/7/30

Y1 - 2016/7/30

N2 - The vascular depression hypothesis postulates that cerebral small vessel disease can cause or exacerbate depression in elderly persons. Numerous studies explored the association of imaging markers of cerebral small vessel disease including white matter lesions (WMLs) and lacunar infarcts with depressive symptoms or disorders. However, cerebral microbleeds have not been tested in depression. In the current study, we aimed to explore the association of WMLs, lacunar infarcts and cerebral microbleeds with depression continuum in a large population-based sample, the Rotterdam Study. Study population consisted of 3799 participants (aged 45 or over) free of dementia. WML volumes, lacunar infarcts and cerebral microbleeds were measured with brain magnetic resonance imaging. Depressive symptoms, depressive disorders and co-morbid anxiety disorders were assessed with validated questionnaires and clinical interview. WML volumes and lacunar infarcts were associated with depressive symptoms and disorders. Cerebral microbleeds, especially in deep or infratentorial brain regions, were related to depressive disorders only. Our results indicate that WMLs and lacunar infarcts might be non-specific vascular lesions seen in depressive symptoms and disorders. Association of cerebral microbleeds with more severe forms of depression may indicate impaired brain iron homeostasis or minor episodes of cerebrovascular extraversion, which may play a role in depression etiology.

AB - The vascular depression hypothesis postulates that cerebral small vessel disease can cause or exacerbate depression in elderly persons. Numerous studies explored the association of imaging markers of cerebral small vessel disease including white matter lesions (WMLs) and lacunar infarcts with depressive symptoms or disorders. However, cerebral microbleeds have not been tested in depression. In the current study, we aimed to explore the association of WMLs, lacunar infarcts and cerebral microbleeds with depression continuum in a large population-based sample, the Rotterdam Study. Study population consisted of 3799 participants (aged 45 or over) free of dementia. WML volumes, lacunar infarcts and cerebral microbleeds were measured with brain magnetic resonance imaging. Depressive symptoms, depressive disorders and co-morbid anxiety disorders were assessed with validated questionnaires and clinical interview. WML volumes and lacunar infarcts were associated with depressive symptoms and disorders. Cerebral microbleeds, especially in deep or infratentorial brain regions, were related to depressive disorders only. Our results indicate that WMLs and lacunar infarcts might be non-specific vascular lesions seen in depressive symptoms and disorders. Association of cerebral microbleeds with more severe forms of depression may indicate impaired brain iron homeostasis or minor episodes of cerebrovascular extraversion, which may play a role in depression etiology.

KW - Anxiety

KW - Cerebral microbleeds

KW - Depressive iisorders

KW - Depressive symptoms

KW - Lacunar infracts

KW - Vascular depression

KW - White matter lesions

UR - http://www.scopus.com/inward/record.url?scp=84969791858&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2016.05.002

DO - 10.1016/j.pscychresns.2016.05.002

M3 - Article

VL - 253

SP - 1

EP - 6

JO - Psychiatry Research - Neuroimaging

T2 - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

ER -

ID: 9624917