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Modelling the immune system response to epithelial wound infections. / Vermolen, Fred; Arkesteijn, Liselot; Gefen, A.

In: Journal of Theoretical Biology, Vol. 393, 2016, p. 158-169.

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Vermolen, Fred ; Arkesteijn, Liselot ; Gefen, A. / Modelling the immune system response to epithelial wound infections. In: Journal of Theoretical Biology. 2016 ; Vol. 393. pp. 158-169.

BibTeX

@article{08f4a46b1a8b45ce9980f31c59342c3e,
title = "Modelling the immune system response to epithelial wound infections",
abstract = "In this paper, a cell-colony based formalism for the healing of superficial wounds is presented. The paper incorporates the migration, proliferation, and death of constituent cells, in the context of wound healing. The present study considers wound healing under ischemic conditions where a bacterial infection develops, which impairs the motility of the constituent cells. In this work, the performance of the immune response system is incorporated in the sense that migrating leukocyte are modelled which engulf the infectious pathogens. The model is based on both deterministic and stochastic principles. Simulation results are discussed in a biological context.",
author = "Fred Vermolen and Liselot Arkesteijn and A Gefen",
year = "2016",
doi = "10.1016/j.jtbi.2015.12.030",
language = "English",
volume = "393",
pages = "158--169",
journal = "Journal of Theoretical Biology",
issn = "0022-5193",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Modelling the immune system response to epithelial wound infections

AU - Vermolen, Fred

AU - Arkesteijn, Liselot

AU - Gefen, A

PY - 2016

Y1 - 2016

N2 - In this paper, a cell-colony based formalism for the healing of superficial wounds is presented. The paper incorporates the migration, proliferation, and death of constituent cells, in the context of wound healing. The present study considers wound healing under ischemic conditions where a bacterial infection develops, which impairs the motility of the constituent cells. In this work, the performance of the immune response system is incorporated in the sense that migrating leukocyte are modelled which engulf the infectious pathogens. The model is based on both deterministic and stochastic principles. Simulation results are discussed in a biological context.

AB - In this paper, a cell-colony based formalism for the healing of superficial wounds is presented. The paper incorporates the migration, proliferation, and death of constituent cells, in the context of wound healing. The present study considers wound healing under ischemic conditions where a bacterial infection develops, which impairs the motility of the constituent cells. In this work, the performance of the immune response system is incorporated in the sense that migrating leukocyte are modelled which engulf the infectious pathogens. The model is based on both deterministic and stochastic principles. Simulation results are discussed in a biological context.

U2 - 10.1016/j.jtbi.2015.12.030

DO - 10.1016/j.jtbi.2015.12.030

M3 - Article

VL - 393

SP - 158

EP - 169

JO - Journal of Theoretical Biology

T2 - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

SN - 0022-5193

ER -

ID: 11146207