TY - JOUR
T1 - Myocardial stretch post-atrial contraction in healthy volunteers and hypertrophic cardiomyopathy patients
AU - Strachinaru, Mihai
AU - Geleijnse, Marcel L.
AU - de Jong, Nico
AU - van den Bosch, Annemien
AU - Michels, Michelle
AU - Schinkel, Arend F. L.
AU - van der Steen, Antonius F. W.
AU - Bosch, Johan G.
AU - Vos, Hendrik J.
PY - 2019
Y1 - 2019
N2 - In cardiac high-frame-rate color tissue Doppler imaging (TDI), a wave-like pattern travels over the interventricular septum (IVS) after atrial contraction. The propagation velocity of this myocardial stretch post-atrial contraction (MSPa) was proposed as a measure of left ventricular stiffness. The aim of our study was to investigate the MSPa in patients with hypertrophic cardiomyopathy (HCM) compared with healthy volunteers. Forty-two healthy volunteers and 33 HCM patients underwent high-frame-rate (>500 Hz) TDI apical echocardiography. MSPa was visible in TDI, M-mode and speckle tracking. When assuming a wave propagating with constant velocity, MSPa in healthy volunteers (1.6 ± 0.3 m/s) did not differ from that in HCM patients (1.8 ± 0.8 m/s, p = 0.14). Yet, in 42% of patients with HCM, the MSPa had a non-constant velocity over the wall: in the basal IVS, the velocity was lower (1.4 ± 0.5 m/s), and in the mid-IVS, much higher (6.1 ± 3.4 m/s, p < 0.0001), and this effect was related to the septal thickness. The reason is hypothesized to be the reaching of maximal longitudinal myocardial distension in HCM patients.
AB - In cardiac high-frame-rate color tissue Doppler imaging (TDI), a wave-like pattern travels over the interventricular septum (IVS) after atrial contraction. The propagation velocity of this myocardial stretch post-atrial contraction (MSPa) was proposed as a measure of left ventricular stiffness. The aim of our study was to investigate the MSPa in patients with hypertrophic cardiomyopathy (HCM) compared with healthy volunteers. Forty-two healthy volunteers and 33 HCM patients underwent high-frame-rate (>500 Hz) TDI apical echocardiography. MSPa was visible in TDI, M-mode and speckle tracking. When assuming a wave propagating with constant velocity, MSPa in healthy volunteers (1.6 ± 0.3 m/s) did not differ from that in HCM patients (1.8 ± 0.8 m/s, p = 0.14). Yet, in 42% of patients with HCM, the MSPa had a non-constant velocity over the wall: in the basal IVS, the velocity was lower (1.4 ± 0.5 m/s), and in the mid-IVS, much higher (6.1 ± 3.4 m/s, p < 0.0001), and this effect was related to the septal thickness. The reason is hypothesized to be the reaching of maximal longitudinal myocardial distension in HCM patients.
KW - Atrial contraction
KW - High-frame-rate tissue Doppler
KW - Myocardial stretch
KW - Stiffness
UR - http://www.scopus.com/inward/record.url?scp=85066239604&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2019.04.031
DO - 10.1016/j.ultrasmedbio.2019.04.031
M3 - Article
SN - 0301-5629
VL - 45
SP - 1987
EP - 1998
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 8
ER -