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Nature helps : Toward bioinspired bactericidal nanopatterns. / Ganjian, Mahya; Modaresifar, Khashayar; Ligeon, Manon R.O.; Kunkels, Lorenzo B.; Tümer, Nazli; Angeloni, Livia; Hagen, Kees; Otten, Linda G.; Hagedoorn, Peter Leon; Apachitei, Iulian; Fratila-Apachitei, Lidy E.; Zadpoor, Amir A.

In: Advanced Materials Interfaces, Vol. 6, No. 16, 1900640, 2019.

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@article{4c4ab4ab210840969ef91d182d3f77f1,
title = "Nature helps: Toward bioinspired bactericidal nanopatterns",
abstract = "Development of synthetic bactericidal surfaces is a drug-free route to the prevention of implant-associated infections. Surface nanotopographies with specific dimensions have been shown to kill various types of bacterial strains through a mechanical mechanism, while regulating stem cell differentiation and tissue regeneration. The effective ranges of dimensions required to simultaneously achieve both aims are in the <200 nm range. Here, a nanoscale additive manufacturing (=3D printing) technique called electron beam induced deposition (EBID) is used to fabricate nanopillars with reproducible and precisely controlled dimensions and arrangements that are within those effective ranges (i.e. a height of 190 nm, a diameter of 80 nm, and an interspacing of 170 nm). When compared to the flat surface, the nanopatterned surfaces show a significant bactericidal activity against both Escherichia coli and Staphylococcus aureus (with respective killing efficiencies of 97 ± 1{\%} and 36 ± 5{\%}). Direct penetration of nanopatterns into the bacterial cell wall leads to the disruption of the cell wall and cell death. The more rigid cell wall of S. aureus is consistent with the decreased killing efficiency. These findings support the development of nanopatterns with precisely controlled dimensions that are capable of killing both Gram-negative and Gram-positive bacteria.",
keywords = "antibacterial effects, biomimetics, nanoscale additive manufacturing, surface nanopatterns",
author = "Mahya Ganjian and Khashayar Modaresifar and Ligeon, {Manon R.O.} and Kunkels, {Lorenzo B.} and Nazli T{\"u}mer and Livia Angeloni and Kees Hagen and Otten, {Linda G.} and Hagedoorn, {Peter Leon} and Iulian Apachitei and Fratila-Apachitei, {Lidy E.} and Zadpoor, {Amir A.}",
year = "2019",
doi = "10.1002/admi.201900640",
language = "English",
volume = "6",
journal = "Advanced Materials Interfaces",
issn = "2196-7350",
publisher = "John Wiley & Sons",
number = "16",

}

RIS

TY - JOUR

T1 - Nature helps

T2 - Advanced Materials Interfaces

AU - Ganjian, Mahya

AU - Modaresifar, Khashayar

AU - Ligeon, Manon R.O.

AU - Kunkels, Lorenzo B.

AU - Tümer, Nazli

AU - Angeloni, Livia

AU - Hagen, Kees

AU - Otten, Linda G.

AU - Hagedoorn, Peter Leon

AU - Apachitei, Iulian

AU - Fratila-Apachitei, Lidy E.

AU - Zadpoor, Amir A.

PY - 2019

Y1 - 2019

N2 - Development of synthetic bactericidal surfaces is a drug-free route to the prevention of implant-associated infections. Surface nanotopographies with specific dimensions have been shown to kill various types of bacterial strains through a mechanical mechanism, while regulating stem cell differentiation and tissue regeneration. The effective ranges of dimensions required to simultaneously achieve both aims are in the <200 nm range. Here, a nanoscale additive manufacturing (=3D printing) technique called electron beam induced deposition (EBID) is used to fabricate nanopillars with reproducible and precisely controlled dimensions and arrangements that are within those effective ranges (i.e. a height of 190 nm, a diameter of 80 nm, and an interspacing of 170 nm). When compared to the flat surface, the nanopatterned surfaces show a significant bactericidal activity against both Escherichia coli and Staphylococcus aureus (with respective killing efficiencies of 97 ± 1% and 36 ± 5%). Direct penetration of nanopatterns into the bacterial cell wall leads to the disruption of the cell wall and cell death. The more rigid cell wall of S. aureus is consistent with the decreased killing efficiency. These findings support the development of nanopatterns with precisely controlled dimensions that are capable of killing both Gram-negative and Gram-positive bacteria.

AB - Development of synthetic bactericidal surfaces is a drug-free route to the prevention of implant-associated infections. Surface nanotopographies with specific dimensions have been shown to kill various types of bacterial strains through a mechanical mechanism, while regulating stem cell differentiation and tissue regeneration. The effective ranges of dimensions required to simultaneously achieve both aims are in the <200 nm range. Here, a nanoscale additive manufacturing (=3D printing) technique called electron beam induced deposition (EBID) is used to fabricate nanopillars with reproducible and precisely controlled dimensions and arrangements that are within those effective ranges (i.e. a height of 190 nm, a diameter of 80 nm, and an interspacing of 170 nm). When compared to the flat surface, the nanopatterned surfaces show a significant bactericidal activity against both Escherichia coli and Staphylococcus aureus (with respective killing efficiencies of 97 ± 1% and 36 ± 5%). Direct penetration of nanopatterns into the bacterial cell wall leads to the disruption of the cell wall and cell death. The more rigid cell wall of S. aureus is consistent with the decreased killing efficiency. These findings support the development of nanopatterns with precisely controlled dimensions that are capable of killing both Gram-negative and Gram-positive bacteria.

KW - antibacterial effects

KW - biomimetics

KW - nanoscale additive manufacturing

KW - surface nanopatterns

UR - http://www.scopus.com/inward/record.url?scp=85067351867&partnerID=8YFLogxK

U2 - 10.1002/admi.201900640

DO - 10.1002/admi.201900640

M3 - Article

VL - 6

JO - Advanced Materials Interfaces

JF - Advanced Materials Interfaces

SN - 2196-7350

IS - 16

M1 - 1900640

ER -

ID: 54787661