TY - JOUR
T1 - Negatively Charged Lipid Membranes Catalyze Supramolecular Hydrogel Formation
AU - Versluis, Frank
AU - Van Elsland, Daphne M.
AU - Mytnyk, Serhii
AU - Perrier, Dayinta L.
AU - Trausel, Fanny
AU - Poolman, Jos M.
AU - Maity, Chandan
AU - Le Sage, Vincent A A
AU - Van Kasteren, Sander I.
AU - Van Esch, Jan H.
AU - Eelkema, Rienk
PY - 2016/7/20
Y1 - 2016/7/20
N2 - In this contribution we show that biological membranes can catalyze the formation of supramolecular hydrogel networks. Negatively charged lipid membranes can generate a local proton gradient, accelerating the acid-catalyzed formation of hydrazone-based supramolecular gelators near the membrane. Synthetic lipid membranes can be used to tune the physical properties of the resulting multicomponent gels as a function of lipid concentration. Moreover, the catalytic activity of lipid membranes and the formation of gel networks around these supramolecular structures are controlled by the charge and phase behavior of the lipid molecules. Finally, we show that the insights obtained from synthetic membranes can be translated to biological membranes, enabling the formation of gel fibers on living HeLa cells.
AB - In this contribution we show that biological membranes can catalyze the formation of supramolecular hydrogel networks. Negatively charged lipid membranes can generate a local proton gradient, accelerating the acid-catalyzed formation of hydrazone-based supramolecular gelators near the membrane. Synthetic lipid membranes can be used to tune the physical properties of the resulting multicomponent gels as a function of lipid concentration. Moreover, the catalytic activity of lipid membranes and the formation of gel networks around these supramolecular structures are controlled by the charge and phase behavior of the lipid molecules. Finally, we show that the insights obtained from synthetic membranes can be translated to biological membranes, enabling the formation of gel fibers on living HeLa cells.
UR - http://www.scopus.com/inward/record.url?scp=84979284162&partnerID=8YFLogxK
U2 - 10.1021/jacs.6b03853
DO - 10.1021/jacs.6b03853
M3 - Article
AN - SCOPUS:84979284162
SN - 0002-7863
VL - 138
SP - 8670
EP - 8673
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 28
ER -