TY - GEN
T1 - Non-linear parameter estimation of volume sensitivity of the coronary resistance in the isolated canine septum
AU - Cornelissen, AJM
AU - Chan, Charly
AU - Dankelman, Jenny
AU - Yin, Frank C.P.
AU - Spaan, Jos A.E.
PY - 1996
Y1 - 1996
N2 - Common parameters to describe the coronary circulation are resistances (Rs) and capacitances (Cs). In six isolated, maximally dilated, perfused, non contracting canine interventricular septa, the Rs and Cs at different pressure levels were estimated by obtaining the inflow-pressure transfer functions (Q/P) and volume-pressure transfer functions (T/P). To interpret the data, simple lumped two compartment RCR models were fitted. Models with fixed resistances could not fit simultaneously Q/P and T/P. Therefore models with volume dependent parameters were tested as well. However, these models had more parameters, which could not be uniquely identified from the data. Many parameter sets, which predicted adequate transfer functions, were created. After comparing these parameter sets, it was concluded that the first resistance and the first capacitance could be estimated, furthermore a relation between the distal capacitance and the volume sensitivity of the third resistance was found: the higher the capacitance, the lower the sensitivity.
AB - Common parameters to describe the coronary circulation are resistances (Rs) and capacitances (Cs). In six isolated, maximally dilated, perfused, non contracting canine interventricular septa, the Rs and Cs at different pressure levels were estimated by obtaining the inflow-pressure transfer functions (Q/P) and volume-pressure transfer functions (T/P). To interpret the data, simple lumped two compartment RCR models were fitted. Models with fixed resistances could not fit simultaneously Q/P and T/P. Therefore models with volume dependent parameters were tested as well. However, these models had more parameters, which could not be uniquely identified from the data. Many parameter sets, which predicted adequate transfer functions, were created. After comparing these parameter sets, it was concluded that the first resistance and the first capacitance could be estimated, furthermore a relation between the distal capacitance and the volume sensitivity of the third resistance was found: the higher the capacitance, the lower the sensitivity.
UR - http://www.scopus.com/inward/record.url?scp=0030312638&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:0030312638
VL - 4
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 1752
EP - 1753
BT - Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PB - IEEE
CY - Piscataway, NJ,USA
T2 - Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5)
Y2 - 31 October 1996 through 3 November 1996
ER -