Abstract
An "on water" organocatalytic cyanoarylmethylation of aryl acetonitrile to isatins is developed, giving products in high yields and up to excellent diastereoselectivities. A remarkable enhancement of reaction rates and diastereoselectivities by water was observed under mild conditions. Moreover, this approach provides a highly efficient and environmentally benign access to thermodynamic 3-hydroxy-3-cyanomethyl oxindoles.
Original language | English |
---|---|
Pages (from-to) | 4000-4008 |
Number of pages | 9 |
Journal | Journal of Organic Chemistry |
Volume | 84 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2019 |