TY - JOUR
T1 - Optical coherence tomography attenuation imaging for lipid core detection
T2 - an ex-vivo validation study
AU - Gnanadesigan, Muthukaruppan
AU - Hussain, Ali S.
AU - White, Stephen
AU - Scoltock, Simon
AU - Baumbach, Andreas
AU - van der Steen, Antonius F.W.
AU - Regar, Evelyn
AU - Johnson, Thomas W.
AU - van Soest, Gijs
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Lipid-core atherosclerotic plaques are associated with disease progression, procedural complications, and cardiac events. Coronary plaque lipid can be quantified in optical coherence tomography (OCT) pullbacks by measurement of lipid arcs and lipid lengths; parameters frequently used in clinical research, but labor intensive and subjective to analyse. In this study, we investigated the ability of quantitative attenuation, derived from intravascular OCT, to detect plaque lipid. Lipid cores are associated with a high attenuation coefficient. We compared the index of plaque attenuation (IPA), a local quantitative measure of attenuation, to the manually measured lipid score (arc and length) on OCT images, and to the plaque characterization ex-vivo. We confirmed a correlation between the IPA and lipid scores (r2 > 0.7). Comparison to histology shows that high attenuation is associated with fibroatheroma, but also with macrophage presence. IPA is a robust, reproducible, and user-independent measure that facilitates quantification of coronary lipid, a potential tool in clinical research and in guiding percutaneous coronary intervention.
AB - Lipid-core atherosclerotic plaques are associated with disease progression, procedural complications, and cardiac events. Coronary plaque lipid can be quantified in optical coherence tomography (OCT) pullbacks by measurement of lipid arcs and lipid lengths; parameters frequently used in clinical research, but labor intensive and subjective to analyse. In this study, we investigated the ability of quantitative attenuation, derived from intravascular OCT, to detect plaque lipid. Lipid cores are associated with a high attenuation coefficient. We compared the index of plaque attenuation (IPA), a local quantitative measure of attenuation, to the manually measured lipid score (arc and length) on OCT images, and to the plaque characterization ex-vivo. We confirmed a correlation between the IPA and lipid scores (r2 > 0.7). Comparison to histology shows that high attenuation is associated with fibroatheroma, but also with macrophage presence. IPA is a robust, reproducible, and user-independent measure that facilitates quantification of coronary lipid, a potential tool in clinical research and in guiding percutaneous coronary intervention.
KW - Attenuation
KW - Lipid core plaque
KW - Optical coherence tomography
UR - http://resolver.tudelft.nl/uuid:42c3497d-cd22-4f71-8761-f1ad0d77b249
UR - http://www.scopus.com/inward/record.url?scp=84987660617&partnerID=8YFLogxK
U2 - 10.1007/s10554-016-0968-z
DO - 10.1007/s10554-016-0968-z
M3 - Article
C2 - 27620900
SN - 1569-5794
VL - 33
SP - 5
EP - 11
JO - International Journal of Cardiovascular Imaging
JF - International Journal of Cardiovascular Imaging
IS - 1
ER -