TY - JOUR
T1 - Optical System Design for Noncontact, Normal Incidence, THz Imaging of in vivo Human Cornea
AU - Sung, Shijun
AU - Dabironezare, Shahab
AU - Llombart, Nuria
AU - Selvin, Skyler
AU - Bajwa, Neha
AU - Chantra, Somporn
AU - Nowroozi, Bryan
AU - Garritano, James
AU - Goell , Jacob
AU - Li, Alex
AU - Deng, Sophie X.
AU - Brown, Elliott
AU - Grundfest , Warren S.
AU - Taylor, Zachary D.
PY - 2018
Y1 - 2018
N2 - Reflection-mode terahertz (THz) imaging of corneal tissue water content (CTWC) is a proposed method for early accurate detection and study of corneal diseases. Despite promising results from ex vivo and in vivo cornea studies, interpretation of the reflectivity data is confounded by the contact between corneal tissue and dielectric windows used to flatten the imaging field. Herein, we present an optical design for noncontact THz imaging of cornea. A beam-scanning methodology performs angular normal incidence sweeps of a focused beam over the corneal surface while keeping the source, detector, and patient stationary. A quasi-optical analysis method is developed to analyze the theoretical resolution and imaging field intensity profile. These results are compared to the electric field distribution computed with a physical optics analysis code. Imaging experiments validate the optical theories behind the design and suggest that quasi-optical methods are sufficient for designing of THz corneal imaging systems. Successful imaging operations support the feasibility of noncontact in vivo imaging. We believe that this optical system design will enable the first, clinically relevant, in vivo exploration of CTWC using THz technology.
AB - Reflection-mode terahertz (THz) imaging of corneal tissue water content (CTWC) is a proposed method for early accurate detection and study of corneal diseases. Despite promising results from ex vivo and in vivo cornea studies, interpretation of the reflectivity data is confounded by the contact between corneal tissue and dielectric windows used to flatten the imaging field. Herein, we present an optical design for noncontact THz imaging of cornea. A beam-scanning methodology performs angular normal incidence sweeps of a focused beam over the corneal surface while keeping the source, detector, and patient stationary. A quasi-optical analysis method is developed to analyze the theoretical resolution and imaging field intensity profile. These results are compared to the electric field distribution computed with a physical optics analysis code. Imaging experiments validate the optical theories behind the design and suggest that quasi-optical methods are sufficient for designing of THz corneal imaging systems. Successful imaging operations support the feasibility of noncontact in vivo imaging. We believe that this optical system design will enable the first, clinically relevant, in vivo exploration of CTWC using THz technology.
KW - Biological and medical imaging
KW - clinical instruments
KW - medical diagnostics
KW - terahertz (THz) imaging of cornea
UR - http://www.scopus.com/inward/record.url?scp=85035770462&partnerID=8YFLogxK
U2 - 10.1109/TTHZ.2017.2771754
DO - 10.1109/TTHZ.2017.2771754
M3 - Article
AN - SCOPUS:85035770462
SN - 2156-342X
VL - 8
SP - 1
EP - 12
JO - IEEE Transactions on Terahertz Science and Technology
JF - IEEE Transactions on Terahertz Science and Technology
IS - 1
M1 - 8118096
ER -