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Periodic Switching in a Recombinase-Based Molecular Circuit. / Samaniego, Christian Cuba; Giordano, Giulia; Franco, Elisa.

In: IEEE Control Systems Letters, Vol. 4, No. 1, 2020, p. 241-246.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Samaniego, CC, Giordano, G & Franco, E 2020, 'Periodic Switching in a Recombinase-Based Molecular Circuit' IEEE Control Systems Letters, vol. 4, no. 1, pp. 241-246. https://doi.org/10.1109/LCSYS.2019.2923271

APA

Samaniego, C. C., Giordano, G., & Franco, E. (2020). Periodic Switching in a Recombinase-Based Molecular Circuit. IEEE Control Systems Letters, 4(1), 241-246. https://doi.org/10.1109/LCSYS.2019.2923271

Vancouver

Author

Samaniego, Christian Cuba ; Giordano, Giulia ; Franco, Elisa. / Periodic Switching in a Recombinase-Based Molecular Circuit. In: IEEE Control Systems Letters. 2020 ; Vol. 4, No. 1. pp. 241-246.

BibTeX

@article{911267e9c8c84229a9e6b1479e0c350c,
title = "Periodic Switching in a Recombinase-Based Molecular Circuit",
abstract = "An important challenge in synthetic biology is the construction of periodic circuits with tunable and predictable period. We propose a general architecture, based on the use of recombinase proteins and negative feedback, to build a molecular device for periodic switching between two distinct regimes; the switching rule depends on known concentration thresholds for some circuit components. We analytically characterize the threshold values for which a periodic orbit is guaranteed to exist and attract all trajectories with initial conditions within an invariant set, and we provide expressions for period and amplitude. We describe two distinct biological realizations of the recombinase architecture, and show their capacity to exhibit periodic behaviors via extensive numerical simulations.",
keywords = "Biomolecular systems, systems biology",
author = "Samaniego, {Christian Cuba} and Giulia Giordano and Elisa Franco",
note = "Accepted Author Manuscript",
year = "2020",
doi = "10.1109/LCSYS.2019.2923271",
language = "English",
volume = "4",
pages = "241--246",
journal = "IEEE Control Systems Letters",
issn = "2475-1456",
publisher = "IEEE",
number = "1",

}

RIS

TY - JOUR

T1 - Periodic Switching in a Recombinase-Based Molecular Circuit

AU - Samaniego, Christian Cuba

AU - Giordano, Giulia

AU - Franco, Elisa

N1 - Accepted Author Manuscript

PY - 2020

Y1 - 2020

N2 - An important challenge in synthetic biology is the construction of periodic circuits with tunable and predictable period. We propose a general architecture, based on the use of recombinase proteins and negative feedback, to build a molecular device for periodic switching between two distinct regimes; the switching rule depends on known concentration thresholds for some circuit components. We analytically characterize the threshold values for which a periodic orbit is guaranteed to exist and attract all trajectories with initial conditions within an invariant set, and we provide expressions for period and amplitude. We describe two distinct biological realizations of the recombinase architecture, and show their capacity to exhibit periodic behaviors via extensive numerical simulations.

AB - An important challenge in synthetic biology is the construction of periodic circuits with tunable and predictable period. We propose a general architecture, based on the use of recombinase proteins and negative feedback, to build a molecular device for periodic switching between two distinct regimes; the switching rule depends on known concentration thresholds for some circuit components. We analytically characterize the threshold values for which a periodic orbit is guaranteed to exist and attract all trajectories with initial conditions within an invariant set, and we provide expressions for period and amplitude. We describe two distinct biological realizations of the recombinase architecture, and show their capacity to exhibit periodic behaviors via extensive numerical simulations.

KW - Biomolecular systems

KW - systems biology

UR - http://www.scopus.com/inward/record.url?scp=85068605661&partnerID=8YFLogxK

U2 - 10.1109/LCSYS.2019.2923271

DO - 10.1109/LCSYS.2019.2923271

M3 - Article

VL - 4

SP - 241

EP - 246

JO - IEEE Control Systems Letters

T2 - IEEE Control Systems Letters

JF - IEEE Control Systems Letters

SN - 2475-1456

IS - 1

ER -

ID: 56487225