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Plasma-Driven in Situ Production of Hydrogen Peroxide for Biocatalysis. / Yayci, Abdulkadir; Baraibar, Álvaro Gómez; Krewing, Marco; Fueyo, Elena Fernandez; Hollmann, Frank; Alcalde, Miguel; Kourist, Robert; Bandow, Julia E.

In: ChemSusChem, Vol. 13, No. 8, 2020, p. 2072-2079.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Yayci, A, Baraibar, ÁG, Krewing, M, Fueyo, EF, Hollmann, F, Alcalde, M, Kourist, R & Bandow, JE 2020, 'Plasma-Driven in Situ Production of Hydrogen Peroxide for Biocatalysis', ChemSusChem, vol. 13, no. 8, pp. 2072-2079. https://doi.org/10.1002/cssc.201903438

APA

Yayci, A., Baraibar, Á. G., Krewing, M., Fueyo, E. F., Hollmann, F., Alcalde, M., Kourist, R., & Bandow, J. E. (2020). Plasma-Driven in Situ Production of Hydrogen Peroxide for Biocatalysis. ChemSusChem, 13(8), 2072-2079. https://doi.org/10.1002/cssc.201903438

Vancouver

Yayci A, Baraibar ÁG, Krewing M, Fueyo EF, Hollmann F, Alcalde M et al. Plasma-Driven in Situ Production of Hydrogen Peroxide for Biocatalysis. ChemSusChem. 2020;13(8):2072-2079. https://doi.org/10.1002/cssc.201903438

Author

Yayci, Abdulkadir ; Baraibar, Álvaro Gómez ; Krewing, Marco ; Fueyo, Elena Fernandez ; Hollmann, Frank ; Alcalde, Miguel ; Kourist, Robert ; Bandow, Julia E. / Plasma-Driven in Situ Production of Hydrogen Peroxide for Biocatalysis. In: ChemSusChem. 2020 ; Vol. 13, No. 8. pp. 2072-2079.

BibTeX

@article{cc87f47cd54248ccac0b72e244d70c4e,
title = "Plasma-Driven in Situ Production of Hydrogen Peroxide for Biocatalysis",
abstract = "Peroxidases and peroxygenases are promising classes of enzymes for biocatalysis because of their ability to carry out one-electron oxidation reactions and stereoselective oxyfunctionalizations. However, industrial application is limited, as the major drawback is the sensitivity toward the required peroxide substrates. Herein, we report a novel biocatalysis approach to circumvent this shortcoming: in situ production of H2O2 by dielectric barrier discharge plasma. The discharge plasma can be controlled to produce hydrogen peroxide at desired rates, yielding desired concentrations. Using horseradish peroxidase, it is demonstrated that hydrogen peroxide produced by plasma treatment can drive the enzymatic oxidation of model substrates. Fungal peroxygenase is then employed to convert ethylbenzene to (R)-1-phenylethanol with an ee of >96 % using plasma-generated hydrogen peroxide. As direct treatment of the reaction solution with plasma results in reduced enzyme activity, the use of plasma-treated liquid and protection strategies are investigated to increase total turnover. Technical plasmas present a noninvasive means to drive peroxide-based biotransformations.",
keywords = "biocatalysis, peroxidase, peroxides, peroxygenase, plasma chemistry",
author = "Abdulkadir Yayci and Baraibar, {{\'A}lvaro G{\'o}mez} and Marco Krewing and Fueyo, {Elena Fernandez} and Frank Hollmann and Miguel Alcalde and Robert Kourist and Bandow, {Julia E.}",
year = "2020",
doi = "10.1002/cssc.201903438",
language = "English",
volume = "13",
pages = "2072--2079",
journal = "ChemSusChem (Print): chemistry & sustainability, energy & materials",
issn = "1864-5631",
publisher = "Wiley-VCH",
number = "8",

}

RIS

TY - JOUR

T1 - Plasma-Driven in Situ Production of Hydrogen Peroxide for Biocatalysis

AU - Yayci, Abdulkadir

AU - Baraibar, Álvaro Gómez

AU - Krewing, Marco

AU - Fueyo, Elena Fernandez

AU - Hollmann, Frank

AU - Alcalde, Miguel

AU - Kourist, Robert

AU - Bandow, Julia E.

PY - 2020

Y1 - 2020

N2 - Peroxidases and peroxygenases are promising classes of enzymes for biocatalysis because of their ability to carry out one-electron oxidation reactions and stereoselective oxyfunctionalizations. However, industrial application is limited, as the major drawback is the sensitivity toward the required peroxide substrates. Herein, we report a novel biocatalysis approach to circumvent this shortcoming: in situ production of H2O2 by dielectric barrier discharge plasma. The discharge plasma can be controlled to produce hydrogen peroxide at desired rates, yielding desired concentrations. Using horseradish peroxidase, it is demonstrated that hydrogen peroxide produced by plasma treatment can drive the enzymatic oxidation of model substrates. Fungal peroxygenase is then employed to convert ethylbenzene to (R)-1-phenylethanol with an ee of >96 % using plasma-generated hydrogen peroxide. As direct treatment of the reaction solution with plasma results in reduced enzyme activity, the use of plasma-treated liquid and protection strategies are investigated to increase total turnover. Technical plasmas present a noninvasive means to drive peroxide-based biotransformations.

AB - Peroxidases and peroxygenases are promising classes of enzymes for biocatalysis because of their ability to carry out one-electron oxidation reactions and stereoselective oxyfunctionalizations. However, industrial application is limited, as the major drawback is the sensitivity toward the required peroxide substrates. Herein, we report a novel biocatalysis approach to circumvent this shortcoming: in situ production of H2O2 by dielectric barrier discharge plasma. The discharge plasma can be controlled to produce hydrogen peroxide at desired rates, yielding desired concentrations. Using horseradish peroxidase, it is demonstrated that hydrogen peroxide produced by plasma treatment can drive the enzymatic oxidation of model substrates. Fungal peroxygenase is then employed to convert ethylbenzene to (R)-1-phenylethanol with an ee of >96 % using plasma-generated hydrogen peroxide. As direct treatment of the reaction solution with plasma results in reduced enzyme activity, the use of plasma-treated liquid and protection strategies are investigated to increase total turnover. Technical plasmas present a noninvasive means to drive peroxide-based biotransformations.

KW - biocatalysis

KW - peroxidase

KW - peroxides

KW - peroxygenase

KW - plasma chemistry

UR - http://www.scopus.com/inward/record.url?scp=85081972917&partnerID=8YFLogxK

U2 - 10.1002/cssc.201903438

DO - 10.1002/cssc.201903438

M3 - Article

AN - SCOPUS:85081972917

VL - 13

SP - 2072

EP - 2079

JO - ChemSusChem (Print): chemistry & sustainability, energy & materials

JF - ChemSusChem (Print): chemistry & sustainability, energy & materials

SN - 1864-5631

IS - 8

ER -

ID: 71717632