TY - JOUR
T1 - Polyphenol Liquid-Liquid Extraction Process Development Using NRTL-SAC
AU - Silva, Marcelo
AU - García, Joan Cortada
AU - Ottens, Marcel
PY - 2018/7/18
Y1 - 2018/7/18
N2 - Liquid-liquid extraction (LLE) can be an effective strategy for the purification of polyphenols from a fermentation broth. However, solvents need to be chosen to ensure high extraction capacity and selectivity. For that purpose, a systematic study is here presented, where the partition of different polyphenols - naringin, naringenin, p-coumaric acid, and trans-resveratrol - was measured in different solvents and solvent mixtures and described using the semipredictive NRTL-SAC model. The minimum average absolute deviation obtained, based on predicted activity coefficients, was of 40%. With the exception of naringin, the NRTL-SAC molecular descriptors were estimated using solubility data already available in the literature. The obtained results made it possible to propose suitable LLE-based downstream process schemes for two possible purification scenarios: the recovery of trans-resveratrol and the purification of both naringenin and trans-resveratrol, two similar hydrophobic polyphenols, both from a fermentation broth containing hydrophilic impurities (e.g., sugars, proteins).
AB - Liquid-liquid extraction (LLE) can be an effective strategy for the purification of polyphenols from a fermentation broth. However, solvents need to be chosen to ensure high extraction capacity and selectivity. For that purpose, a systematic study is here presented, where the partition of different polyphenols - naringin, naringenin, p-coumaric acid, and trans-resveratrol - was measured in different solvents and solvent mixtures and described using the semipredictive NRTL-SAC model. The minimum average absolute deviation obtained, based on predicted activity coefficients, was of 40%. With the exception of naringin, the NRTL-SAC molecular descriptors were estimated using solubility data already available in the literature. The obtained results made it possible to propose suitable LLE-based downstream process schemes for two possible purification scenarios: the recovery of trans-resveratrol and the purification of both naringenin and trans-resveratrol, two similar hydrophobic polyphenols, both from a fermentation broth containing hydrophilic impurities (e.g., sugars, proteins).
UR - http://resolver.tudelft.nl/uuid:3dece4c1-f6a5-4367-bd8a-75c500c6e422
UR - http://www.scopus.com/inward/record.url?scp=85048876386&partnerID=8YFLogxK
U2 - 10.1021/acs.iecr.8b00613
DO - 10.1021/acs.iecr.8b00613
M3 - Article
AN - SCOPUS:85048876386
SN - 0888-5885
VL - 57
SP - 9210
EP - 9221
JO - Industrial and Engineering Chemistry Research
JF - Industrial and Engineering Chemistry Research
IS - 28
ER -