@inproceedings{09fd4544687f49c296c3ede279d6900b,
title = "Probabilistic tractography for complex fiber orientations with automatic model selection",
abstract = "Fiber tractography aims to reconstruct white matter (WM) connections in the brain. Challenges in these reconstructions include estimation of the fiber orientations in regions with multiple fiber populations, and the uncertainty in the fiber orientations as a result of noise. In this work, we use a range of multi-tensor models to cope with crossing fibers. The uncertainty in fiber orientation is captured using the Cram{\'e}r-Rao lower bound. Furthermore, model selection is performed based on model complexity and goodness of fit. The performance of the framework on the fibercup phantom and human data was compared to the open source diffusion MRI toolkit Camino for a range of SNRs. Performance was quantified by using the Tractometer measures in the fibercup phantom and by comparing streamline counts of lateral projections of the corpus callosum (CC) in the human data. On the phantom data, the comparison showed that our method performs similar to Camino in crossing fiber regions, whilst performing better in a region with kissing fibers (median angular error of 0.73∘ vs 2.7∘, valid connections of 57% vs 21% when seed is in the corresponding region of interest). Furthermore, the amount of counts in the lateral projections was found to be higher using our method (19–89% increase depending on a subject). Altogether, our method outperforms the reference method on both phantom and human data allowing for in-vivo probabilistic multi fiber tractography with an objective model selection procedure.",
author = "Edwin Versteeg and Frans Vos and Gert Kwakkel and {van der Helm}, Frans and Joor Arkesteijn and Lena Filatova",
year = "2018",
doi = "10.1007/978-3-319-73839-0_9",
language = "English",
isbn = "978-3-319-73838-3",
series = "Mathematics and Visualization ",
publisher = "Springer",
pages = "117--128",
editor = "Enrico Kaden and Francesco Grussu and Lipeng Ning and Tax, {Chantal M.W.} and Jelle Veraart",
booktitle = "Computational Diffusion MRI",
note = "MICCAI Workshop on Computational Diffusion MRI (CDMRI{\textquoteright}17) ; Conference date: 10-09-2017 Through 10-09-2017",
}