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Quantification of aortic pulse wave velocity from a population based cohort : A fully automatic method. / Shahzad, Rahil; Shankar, Arun; Amier, Raquel; Nijveldt, Robin; Westenberg, Jos J.M.; de Roos, Albert; Lelieveldt, Boudewijn P.F.; van Der Geest, Rob J.

In: Journal of Cardiovascular Magnetic Resonance, Vol. 21, No. 1, 27, 2019, p. 1-14.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Shahzad, R, Shankar, A, Amier, R, Nijveldt, R, Westenberg, JJM, de Roos, A, Lelieveldt, BPF & van Der Geest, RJ 2019, 'Quantification of aortic pulse wave velocity from a population based cohort: A fully automatic method' Journal of Cardiovascular Magnetic Resonance, vol. 21, no. 1, 27, pp. 1-14. https://doi.org/10.1186/s12968-019-0530-y

APA

Shahzad, R., Shankar, A., Amier, R., Nijveldt, R., Westenberg, J. J. M., de Roos, A., ... van Der Geest, R. J. (2019). Quantification of aortic pulse wave velocity from a population based cohort: A fully automatic method. Journal of Cardiovascular Magnetic Resonance, 21(1), 1-14. [27]. https://doi.org/10.1186/s12968-019-0530-y

Vancouver

Shahzad R, Shankar A, Amier R, Nijveldt R, Westenberg JJM, de Roos A et al. Quantification of aortic pulse wave velocity from a population based cohort: A fully automatic method. Journal of Cardiovascular Magnetic Resonance. 2019;21(1):1-14. 27. https://doi.org/10.1186/s12968-019-0530-y

Author

Shahzad, Rahil ; Shankar, Arun ; Amier, Raquel ; Nijveldt, Robin ; Westenberg, Jos J.M. ; de Roos, Albert ; Lelieveldt, Boudewijn P.F. ; van Der Geest, Rob J. / Quantification of aortic pulse wave velocity from a population based cohort : A fully automatic method. In: Journal of Cardiovascular Magnetic Resonance. 2019 ; Vol. 21, No. 1. pp. 1-14.

BibTeX

@article{639b103d70c94732b3b3884b44af7aaa,
title = "Quantification of aortic pulse wave velocity from a population based cohort: A fully automatic method",
abstract = "Background: Aortic pulse wave velocity (PWV) is an indicator of aortic stiffness and is used as a predictor of adverse cardiovascular events. PWV can be non-invasively assessed using magnetic resonance imaging (MRI). PWV computation requires two components, the length of the aortic arch and the time taken for the systolic pressure wave to travel through the aortic arch. The aortic length is calculated using a multi-slice 3D scan and the transit time is computed using a 2D velocity encoded MRI (VE) scan. In this study we present and evaluate an automatic method to quantify the aortic pulse wave velocity using a large population-based cohort. Methods: For this study 212 subjects were retrospectively selected from a large multi-center heart-brain connection cohort. For each subject a multi-slice 3D scan of the aorta was acquired in an oblique-sagittal plane and a 2D VE scan acquired in a transverse plane cutting through the proximal ascending and descending aorta. PWV was calculated in three stages: (i) a multi-atlas-based segmentation method was developed to segment the aortic arch from the multi-slice 3D scan and subsequently estimate the length of the proximal aorta, (ii) an algorithm that delineates the proximal ascending and descending aorta from the time-resolved 2D VE scan and subsequently obtains the velocity-time flow curves was also developed, and (iii) automatic methods that can compute the transit time from the velocity-time flow curves were implemented and investigated. Finally the PWV was obtained by combining the aortic length and the transit time. Results: Quantitative evaluation with respect to the length of the aortic arch as well as the computed PWV were performend by comparing the results of the novel automatic method to those obtained manually. The mean absolute difference in aortic length obtained automatically as compared to those obtained manually was 3.3 ± 2.8 mm (p < 0.05), the manual inter-observer variability on a subset of 45 scans was 3.4 ± 3.4 mm (p = 0.49). Bland-Altman analysis between the automataic method and the manual methods showed a bias of 0.0 (-5.0,5.0) m/s for the foot-to-foot approach, -0.1 (-1.2, 1.1) and -0.2 (-2.6, 2.1) m/s for the half-max and the cross-correlation methods, respectively. Conclusion: We proposed and evaluated a fully automatic method to calculate the PWV on a large set of multi-center MRI scans. It was observed that the overall results obtained had very good agreement with manual analysis. Our proposed automatic method would be very beneficial for large population based studies, where manual analysis requires a lot of manpower.",
keywords = "Centerline estimation, Image registration, Multi-atlas-based segmentation, Pulse wave velocity, Velocity encoded MRI",
author = "Rahil Shahzad and Arun Shankar and Raquel Amier and Robin Nijveldt and Westenberg, {Jos J.M.} and {de Roos}, Albert and Lelieveldt, {Boudewijn P.F.} and {van Der Geest}, {Rob J.}",
year = "2019",
doi = "10.1186/s12968-019-0530-y",
language = "English",
volume = "21",
pages = "1--14",
journal = "Journal of Cardiovascular Magnetic Resonance (Print)",
issn = "1097-6647",
publisher = "BioMed Central",
number = "1",

}

RIS

TY - JOUR

T1 - Quantification of aortic pulse wave velocity from a population based cohort

T2 - Journal of Cardiovascular Magnetic Resonance (Print)

AU - Shahzad, Rahil

AU - Shankar, Arun

AU - Amier, Raquel

AU - Nijveldt, Robin

AU - Westenberg, Jos J.M.

AU - de Roos, Albert

AU - Lelieveldt, Boudewijn P.F.

AU - van Der Geest, Rob J.

PY - 2019

Y1 - 2019

N2 - Background: Aortic pulse wave velocity (PWV) is an indicator of aortic stiffness and is used as a predictor of adverse cardiovascular events. PWV can be non-invasively assessed using magnetic resonance imaging (MRI). PWV computation requires two components, the length of the aortic arch and the time taken for the systolic pressure wave to travel through the aortic arch. The aortic length is calculated using a multi-slice 3D scan and the transit time is computed using a 2D velocity encoded MRI (VE) scan. In this study we present and evaluate an automatic method to quantify the aortic pulse wave velocity using a large population-based cohort. Methods: For this study 212 subjects were retrospectively selected from a large multi-center heart-brain connection cohort. For each subject a multi-slice 3D scan of the aorta was acquired in an oblique-sagittal plane and a 2D VE scan acquired in a transverse plane cutting through the proximal ascending and descending aorta. PWV was calculated in three stages: (i) a multi-atlas-based segmentation method was developed to segment the aortic arch from the multi-slice 3D scan and subsequently estimate the length of the proximal aorta, (ii) an algorithm that delineates the proximal ascending and descending aorta from the time-resolved 2D VE scan and subsequently obtains the velocity-time flow curves was also developed, and (iii) automatic methods that can compute the transit time from the velocity-time flow curves were implemented and investigated. Finally the PWV was obtained by combining the aortic length and the transit time. Results: Quantitative evaluation with respect to the length of the aortic arch as well as the computed PWV were performend by comparing the results of the novel automatic method to those obtained manually. The mean absolute difference in aortic length obtained automatically as compared to those obtained manually was 3.3 ± 2.8 mm (p < 0.05), the manual inter-observer variability on a subset of 45 scans was 3.4 ± 3.4 mm (p = 0.49). Bland-Altman analysis between the automataic method and the manual methods showed a bias of 0.0 (-5.0,5.0) m/s for the foot-to-foot approach, -0.1 (-1.2, 1.1) and -0.2 (-2.6, 2.1) m/s for the half-max and the cross-correlation methods, respectively. Conclusion: We proposed and evaluated a fully automatic method to calculate the PWV on a large set of multi-center MRI scans. It was observed that the overall results obtained had very good agreement with manual analysis. Our proposed automatic method would be very beneficial for large population based studies, where manual analysis requires a lot of manpower.

AB - Background: Aortic pulse wave velocity (PWV) is an indicator of aortic stiffness and is used as a predictor of adverse cardiovascular events. PWV can be non-invasively assessed using magnetic resonance imaging (MRI). PWV computation requires two components, the length of the aortic arch and the time taken for the systolic pressure wave to travel through the aortic arch. The aortic length is calculated using a multi-slice 3D scan and the transit time is computed using a 2D velocity encoded MRI (VE) scan. In this study we present and evaluate an automatic method to quantify the aortic pulse wave velocity using a large population-based cohort. Methods: For this study 212 subjects were retrospectively selected from a large multi-center heart-brain connection cohort. For each subject a multi-slice 3D scan of the aorta was acquired in an oblique-sagittal plane and a 2D VE scan acquired in a transverse plane cutting through the proximal ascending and descending aorta. PWV was calculated in three stages: (i) a multi-atlas-based segmentation method was developed to segment the aortic arch from the multi-slice 3D scan and subsequently estimate the length of the proximal aorta, (ii) an algorithm that delineates the proximal ascending and descending aorta from the time-resolved 2D VE scan and subsequently obtains the velocity-time flow curves was also developed, and (iii) automatic methods that can compute the transit time from the velocity-time flow curves were implemented and investigated. Finally the PWV was obtained by combining the aortic length and the transit time. Results: Quantitative evaluation with respect to the length of the aortic arch as well as the computed PWV were performend by comparing the results of the novel automatic method to those obtained manually. The mean absolute difference in aortic length obtained automatically as compared to those obtained manually was 3.3 ± 2.8 mm (p < 0.05), the manual inter-observer variability on a subset of 45 scans was 3.4 ± 3.4 mm (p = 0.49). Bland-Altman analysis between the automataic method and the manual methods showed a bias of 0.0 (-5.0,5.0) m/s for the foot-to-foot approach, -0.1 (-1.2, 1.1) and -0.2 (-2.6, 2.1) m/s for the half-max and the cross-correlation methods, respectively. Conclusion: We proposed and evaluated a fully automatic method to calculate the PWV on a large set of multi-center MRI scans. It was observed that the overall results obtained had very good agreement with manual analysis. Our proposed automatic method would be very beneficial for large population based studies, where manual analysis requires a lot of manpower.

KW - Centerline estimation

KW - Image registration

KW - Multi-atlas-based segmentation

KW - Pulse wave velocity

KW - Velocity encoded MRI

UR - http://www.scopus.com/inward/record.url?scp=85065714249&partnerID=8YFLogxK

U2 - 10.1186/s12968-019-0530-y

DO - 10.1186/s12968-019-0530-y

M3 - Article

VL - 21

SP - 1

EP - 14

JO - Journal of Cardiovascular Magnetic Resonance (Print)

JF - Journal of Cardiovascular Magnetic Resonance (Print)

SN - 1097-6647

IS - 1

M1 - 27

ER -

ID: 54072358