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Retinal neurodegeneration and brain MRI markers : The Rotterdam Study. / Mutlu, Unal; Bonnemaijer, Pieter W.M.; Ikram, M. Arfan; Colijn, Johanna M.; Cremers, Lotte G M; Buitendijk, Gabriëlle H.S.; Vingerling, Johannes R.; Niessen, Wiro J.; Vernooij, Meike W.; Klaver, Caroline C W; Ikram, M. Kamran.

In: Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, Vol. 60, 01.12.2017, p. 183-191.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Mutlu, U, Bonnemaijer, PWM, Ikram, MA, Colijn, JM, Cremers, LGM, Buitendijk, GHS, Vingerling, JR, Niessen, WJ, Vernooij, MW, Klaver, CCW & Ikram, MK 2017, 'Retinal neurodegeneration and brain MRI markers: The Rotterdam Study' Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, vol. 60, pp. 183-191. https://doi.org/10.1016/j.neurobiolaging.2017.09.003

APA

Mutlu, U., Bonnemaijer, P. W. M., Ikram, M. A., Colijn, J. M., Cremers, L. G. M., Buitendijk, G. H. S., ... Ikram, M. K. (2017). Retinal neurodegeneration and brain MRI markers: The Rotterdam Study. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 60, 183-191. https://doi.org/10.1016/j.neurobiolaging.2017.09.003

Vancouver

Mutlu U, Bonnemaijer PWM, Ikram MA, Colijn JM, Cremers LGM, Buitendijk GHS et al. Retinal neurodegeneration and brain MRI markers: The Rotterdam Study. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology. 2017 Dec 1;60:183-191. https://doi.org/10.1016/j.neurobiolaging.2017.09.003

Author

Mutlu, Unal ; Bonnemaijer, Pieter W.M. ; Ikram, M. Arfan ; Colijn, Johanna M. ; Cremers, Lotte G M ; Buitendijk, Gabriëlle H.S. ; Vingerling, Johannes R. ; Niessen, Wiro J. ; Vernooij, Meike W. ; Klaver, Caroline C W ; Ikram, M. Kamran. / Retinal neurodegeneration and brain MRI markers : The Rotterdam Study. In: Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology. 2017 ; Vol. 60. pp. 183-191.

BibTeX

@article{c842248887294d1abb8b1ebbeedec718,
title = "Retinal neurodegeneration and brain MRI markers: The Rotterdam Study",
abstract = "We investigated the association of specific retinal sublayer thicknesses on optical coherence tomography (OCT) with brain magnetic resonance imaging (MRI) markers. We included 2124 persons (mean age 67.0 years; 56{\%} women) from the Rotterdam Study who had gradable retinal OCT images and brain MRI scans. Thickness of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer were measured on OCT images. Volumetric, microstructural, and focal markers of brain tissue were assessed on MRI. We found that thinner RNFL, GCL, and inner plexiform layer were associated with smaller gray-matter and white-matter volume. Furthermore, we found that thinner RNFL and GCL were associated with worse white-matter microstructure. No association was found between retinal sublayer thickness and white-matter lesion volumes, cerebral microbleeds, or lacunar infarcts. Markers of retinal neurodegeneration are associated with markers of cerebral atrophy, suggesting that retinal OCT may provide information on neurodegeneration in the brain.",
keywords = "Epidemiology, Imaging, MRI, Neurodegeneration, Population based",
author = "Unal Mutlu and Bonnemaijer, {Pieter W.M.} and Ikram, {M. Arfan} and Colijn, {Johanna M.} and Cremers, {Lotte G M} and Buitendijk, {Gabri{\"e}lle H.S.} and Vingerling, {Johannes R.} and Niessen, {Wiro J.} and Vernooij, {Meike W.} and Klaver, {Caroline C W} and Ikram, {M. Kamran}",
year = "2017",
month = "12",
day = "1",
doi = "10.1016/j.neurobiolaging.2017.09.003",
language = "English",
volume = "60",
pages = "183--191",
journal = "Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology",
issn = "0197-4580",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Retinal neurodegeneration and brain MRI markers

T2 - Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology

AU - Mutlu, Unal

AU - Bonnemaijer, Pieter W.M.

AU - Ikram, M. Arfan

AU - Colijn, Johanna M.

AU - Cremers, Lotte G M

AU - Buitendijk, Gabriëlle H.S.

AU - Vingerling, Johannes R.

AU - Niessen, Wiro J.

AU - Vernooij, Meike W.

AU - Klaver, Caroline C W

AU - Ikram, M. Kamran

PY - 2017/12/1

Y1 - 2017/12/1

N2 - We investigated the association of specific retinal sublayer thicknesses on optical coherence tomography (OCT) with brain magnetic resonance imaging (MRI) markers. We included 2124 persons (mean age 67.0 years; 56% women) from the Rotterdam Study who had gradable retinal OCT images and brain MRI scans. Thickness of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer were measured on OCT images. Volumetric, microstructural, and focal markers of brain tissue were assessed on MRI. We found that thinner RNFL, GCL, and inner plexiform layer were associated with smaller gray-matter and white-matter volume. Furthermore, we found that thinner RNFL and GCL were associated with worse white-matter microstructure. No association was found between retinal sublayer thickness and white-matter lesion volumes, cerebral microbleeds, or lacunar infarcts. Markers of retinal neurodegeneration are associated with markers of cerebral atrophy, suggesting that retinal OCT may provide information on neurodegeneration in the brain.

AB - We investigated the association of specific retinal sublayer thicknesses on optical coherence tomography (OCT) with brain magnetic resonance imaging (MRI) markers. We included 2124 persons (mean age 67.0 years; 56% women) from the Rotterdam Study who had gradable retinal OCT images and brain MRI scans. Thickness of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer were measured on OCT images. Volumetric, microstructural, and focal markers of brain tissue were assessed on MRI. We found that thinner RNFL, GCL, and inner plexiform layer were associated with smaller gray-matter and white-matter volume. Furthermore, we found that thinner RNFL and GCL were associated with worse white-matter microstructure. No association was found between retinal sublayer thickness and white-matter lesion volumes, cerebral microbleeds, or lacunar infarcts. Markers of retinal neurodegeneration are associated with markers of cerebral atrophy, suggesting that retinal OCT may provide information on neurodegeneration in the brain.

KW - Epidemiology

KW - Imaging

KW - MRI

KW - Neurodegeneration

KW - Population based

UR - http://www.scopus.com/inward/record.url?scp=85030170276&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2017.09.003

DO - 10.1016/j.neurobiolaging.2017.09.003

M3 - Article

VL - 60

SP - 183

EP - 191

JO - Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology

JF - Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology

SN - 0197-4580

ER -

ID: 33424011