• Wuyuan Zhang
  • Elena Fernández-Fueyo
  • Yan Ni
  • Morten Van Schie
  • Jenö Gacs
  • Rokus Renirie
  • Ron Wever
  • Francesco G. Mutti
  • Dörte Rother
  • Miguel Alcalde
  • Frank Hollmann

Peroxygenases offer an attractive means to address challenges in selective oxyfunctionalization chemistry. Despite this, their application in synthetic chemistry remains challenging due to their facile inactivation by the stoichiometric oxidant H2O2. Often atom-inefficient peroxide generation systems are required, which show little potential for large-scale implementation. Here, we show that visible-light-driven, catalytic water oxidation can be used for in situ generation of H2O2 from water, rendering the peroxygenase catalytically active. In this way, the stereoselective oxyfunctionalization of hydrocarbons can be achieved by simply using the catalytic system, water and visible light.

Original languageEnglish
Pages (from-to)55-62
Number of pages8
JournalNature Catalysis
Issue number1
Publication statusPublished - 1 Jan 2018

ID: 45701672