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Selective Water Addition : Investigations of hydratases from the genus Rhodococcus. / Busch, Hanna.

2020. 180 p.

Research output: ThesisDissertation (TU Delft)

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@phdthesis{a99df4326f4d4da990fdc756c67e71a8,
title = "Selective Water Addition: Investigations of hydratases from the genus Rhodococcus",
abstract = "Water addition reactions to (un)-activated double bonds are very rewarding reactions as they elegantly introduce a hydroxyl-group thereby often adding value to the generated product by establishing a novel stereocentre in tertiary, chiral alcohols. However, performing selective water addition reactions is an extremely challenging task using classical, chemical approaches. Next to overall unfavourable reaction equilibria, the unreactive water molecule is a poor nucleophile and therefore requires activation. Furthermore, due to its small size, a controlled, stereo- and regioselective addition is difficult to achieve. Consequently, establishing straightforward processes with a preferably high selectivity under reaction conditions as environmentally benign as possible is of high interest to both industry and academia...",
keywords = "Rhodococcus, hydratases, omics, water addition, Michael addition, fatty acids",
author = "Hanna Busch",
year = "2020",
doi = "10.4233/uuid:a99df432-6f4d-4da9-90fd-c756c67e71a8",
language = "English",
isbn = "9789464020373",
school = "Delft University of Technology",

}

RIS

TY - THES

T1 - Selective Water Addition

T2 - Investigations of hydratases from the genus Rhodococcus

AU - Busch, Hanna

PY - 2020

Y1 - 2020

N2 - Water addition reactions to (un)-activated double bonds are very rewarding reactions as they elegantly introduce a hydroxyl-group thereby often adding value to the generated product by establishing a novel stereocentre in tertiary, chiral alcohols. However, performing selective water addition reactions is an extremely challenging task using classical, chemical approaches. Next to overall unfavourable reaction equilibria, the unreactive water molecule is a poor nucleophile and therefore requires activation. Furthermore, due to its small size, a controlled, stereo- and regioselective addition is difficult to achieve. Consequently, establishing straightforward processes with a preferably high selectivity under reaction conditions as environmentally benign as possible is of high interest to both industry and academia...

AB - Water addition reactions to (un)-activated double bonds are very rewarding reactions as they elegantly introduce a hydroxyl-group thereby often adding value to the generated product by establishing a novel stereocentre in tertiary, chiral alcohols. However, performing selective water addition reactions is an extremely challenging task using classical, chemical approaches. Next to overall unfavourable reaction equilibria, the unreactive water molecule is a poor nucleophile and therefore requires activation. Furthermore, due to its small size, a controlled, stereo- and regioselective addition is difficult to achieve. Consequently, establishing straightforward processes with a preferably high selectivity under reaction conditions as environmentally benign as possible is of high interest to both industry and academia...

KW - Rhodococcus

KW - hydratases

KW - omics

KW - water addition

KW - Michael addition

KW - fatty acids

U2 - 10.4233/uuid:a99df432-6f4d-4da9-90fd-c756c67e71a8

DO - 10.4233/uuid:a99df432-6f4d-4da9-90fd-c756c67e71a8

M3 - Dissertation (TU Delft)

SN - 9789464020373

ER -

ID: 67897056