We show here that adhesion to a solid substrate increases the resonance frequency of a lipid-coated microbubble by causing an apparent increase in shell stiffness. Using our previously developed photoacoustic measurement technique to drive individual microbubbles into small-amplitude oscillations, we found that biotinylated microbubbles adherent to a streptavidin-coated glass coverslip had much higher resonance frequencies than unbound microbubbles. The frequency responses of the bound microbubbles agree well with a linearized form of the modified Rayleigh-Plesset model with an added increase of shell elasticity. The apparent shell elasticity increased from 0.5 N/m for unbound microbubbles to 2.6 N/m. These findings may be used to better understand microbubble dynamics for applications in ultrasound imaging and therapy.

Original languageEnglish
Title of host publication2019 IEEE International Ultrasonics Symposium, IUS 2019
EditorsSandy Cochran, Margaret Lucas
ISBN (Electronic)9781728145969
Publication statusPublished - 2019
Event2019 IEEE International Ultrasonics Symposium, IUS 2019 - Glasgow, United Kingdom
Duration: 6 Oct 20199 Oct 2019


Conference2019 IEEE International Ultrasonics Symposium, IUS 2019
CountryUnited Kingdom

    Research areas

  • adhesion, resonance frequency, shell elasticity

ID: 68752521