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The anatomical location shapes the immune infiltrate in tumors of same etiology and affects survival. / Santegoets, Saskia J.; van Ham, Vanessa J.; Ehsan, Ilina; Charoentong, Pornpimol; Duurland, Chantal L.; van Unen, Vincent; Hollt, Thomas; van der Velden, Lilly Ann; van der Burg, Sjoerd H.; More Authors.

In: Clinical Cancer Research, Vol. 25, No. 1, 2019, p. 240-252.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Santegoets, SJ, van Ham, VJ, Ehsan, I, Charoentong, P, Duurland, CL, van Unen, V, Hollt, T, van der Velden, LA, van der Burg, SH & More Authors 2019, 'The anatomical location shapes the immune infiltrate in tumors of same etiology and affects survival' Clinical Cancer Research, vol. 25, no. 1, pp. 240-252. https://doi.org/10.1158/1078-0432.CCR-18-1749

APA

Santegoets, S. J., van Ham, V. J., Ehsan, I., Charoentong, P., Duurland, C. L., van Unen, V., ... More Authors (2019). The anatomical location shapes the immune infiltrate in tumors of same etiology and affects survival. Clinical Cancer Research, 25(1), 240-252. https://doi.org/10.1158/1078-0432.CCR-18-1749

Vancouver

Santegoets SJ, van Ham VJ, Ehsan I, Charoentong P, Duurland CL, van Unen V et al. The anatomical location shapes the immune infiltrate in tumors of same etiology and affects survival. Clinical Cancer Research. 2019;25(1):240-252. https://doi.org/10.1158/1078-0432.CCR-18-1749

Author

Santegoets, Saskia J. ; van Ham, Vanessa J. ; Ehsan, Ilina ; Charoentong, Pornpimol ; Duurland, Chantal L. ; van Unen, Vincent ; Hollt, Thomas ; van der Velden, Lilly Ann ; van der Burg, Sjoerd H. ; More Authors. / The anatomical location shapes the immune infiltrate in tumors of same etiology and affects survival. In: Clinical Cancer Research. 2019 ; Vol. 25, No. 1. pp. 240-252.

BibTeX

@article{9c3302c772e84ce280f266da365bc4ca,
title = "The anatomical location shapes the immune infiltrate in tumors of same etiology and affects survival",
abstract = "Purpose: The tumor immune microenvironment determines clinical outcome. Whether the original tissue in which a primary tumor develops influences this microenvironment is not well understood. Experimental Design: We applied high-dimensional single-cell mass cytometry [Cytometry by Time-Of-Flight (CyTOF)] analysis and functional studies to analyze immune cell populations in human papillomavirus (HPV)–induced primary tumors of the cervix (cervical carcinoma) and oropharynx (oropharyngeal squamous cell carcinoma, OPSCC). Results: Despite the same etiology of these tumors, the composition and functionality of their lymphocytic infiltrate substantially differed. Cervical carcinoma displayed a 3-fold lower CD4:CD8 ratio and contained more activated CD8{\th}CD103{\th}CD161{\th} effector T cells and less CD4{\th}CD161{\th} effector memory T cells than OPSCC. CD161{\th} effector cells produced the highest cytokine levels among tumor-specific T cells. Differences in CD4{\th} T-cell infiltration between cervical carcinoma and OPSCC were reflected in the detection rate of intratumoral HPV-specific CD4{\th} T cells and in their impact on OPSCC and cervical carcinoma survival. The peripheral blood mononuclear cell composition of these patients, however, was similar. Conclusions: The tissue of origin significantly affects the overall shape of the immune infiltrate in primary tumors.",
author = "Santegoets, {Saskia J.} and {van Ham}, {Vanessa J.} and Ilina Ehsan and Pornpimol Charoentong and Duurland, {Chantal L.} and {van Unen}, Vincent and Thomas Hollt and {van der Velden}, {Lilly Ann} and {van der Burg}, {Sjoerd H.} and {More Authors}",
year = "2019",
doi = "10.1158/1078-0432.CCR-18-1749",
language = "English",
volume = "25",
pages = "240--252",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - The anatomical location shapes the immune infiltrate in tumors of same etiology and affects survival

AU - Santegoets, Saskia J.

AU - van Ham, Vanessa J.

AU - Ehsan, Ilina

AU - Charoentong, Pornpimol

AU - Duurland, Chantal L.

AU - van Unen, Vincent

AU - Hollt, Thomas

AU - van der Velden, Lilly Ann

AU - van der Burg, Sjoerd H.

AU - More Authors, null

PY - 2019

Y1 - 2019

N2 - Purpose: The tumor immune microenvironment determines clinical outcome. Whether the original tissue in which a primary tumor develops influences this microenvironment is not well understood. Experimental Design: We applied high-dimensional single-cell mass cytometry [Cytometry by Time-Of-Flight (CyTOF)] analysis and functional studies to analyze immune cell populations in human papillomavirus (HPV)–induced primary tumors of the cervix (cervical carcinoma) and oropharynx (oropharyngeal squamous cell carcinoma, OPSCC). Results: Despite the same etiology of these tumors, the composition and functionality of their lymphocytic infiltrate substantially differed. Cervical carcinoma displayed a 3-fold lower CD4:CD8 ratio and contained more activated CD8þCD103þCD161þ effector T cells and less CD4þCD161þ effector memory T cells than OPSCC. CD161þ effector cells produced the highest cytokine levels among tumor-specific T cells. Differences in CD4þ T-cell infiltration between cervical carcinoma and OPSCC were reflected in the detection rate of intratumoral HPV-specific CD4þ T cells and in their impact on OPSCC and cervical carcinoma survival. The peripheral blood mononuclear cell composition of these patients, however, was similar. Conclusions: The tissue of origin significantly affects the overall shape of the immune infiltrate in primary tumors.

AB - Purpose: The tumor immune microenvironment determines clinical outcome. Whether the original tissue in which a primary tumor develops influences this microenvironment is not well understood. Experimental Design: We applied high-dimensional single-cell mass cytometry [Cytometry by Time-Of-Flight (CyTOF)] analysis and functional studies to analyze immune cell populations in human papillomavirus (HPV)–induced primary tumors of the cervix (cervical carcinoma) and oropharynx (oropharyngeal squamous cell carcinoma, OPSCC). Results: Despite the same etiology of these tumors, the composition and functionality of their lymphocytic infiltrate substantially differed. Cervical carcinoma displayed a 3-fold lower CD4:CD8 ratio and contained more activated CD8þCD103þCD161þ effector T cells and less CD4þCD161þ effector memory T cells than OPSCC. CD161þ effector cells produced the highest cytokine levels among tumor-specific T cells. Differences in CD4þ T-cell infiltration between cervical carcinoma and OPSCC were reflected in the detection rate of intratumoral HPV-specific CD4þ T cells and in their impact on OPSCC and cervical carcinoma survival. The peripheral blood mononuclear cell composition of these patients, however, was similar. Conclusions: The tissue of origin significantly affects the overall shape of the immune infiltrate in primary tumors.

UR - http://www.scopus.com/inward/record.url?scp=85059457688&partnerID=8YFLogxK

U2 - 10.1158/1078-0432.CCR-18-1749

DO - 10.1158/1078-0432.CCR-18-1749

M3 - Article

VL - 25

SP - 240

EP - 252

JO - Clinical Cancer Research

T2 - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 1

ER -

ID: 51369169