The application of atomic layer deposition in the production of sorbents for 99Mo/99mTc generator

J. L.T.M. Moret; J. Alkemade; T. M. Upcraft; E. Oehlke; H. T. Wolterbeek; J. R. van Ommen; A. G. Denkova

doi:10.1016/j.apradiso.2020.109266

The application of atomic layer deposition in the production of sorbents for ⁹⁹Mo/^99mTc generator

J. L.T.M. Moret, J. Alkemade, T. M. Upcraft, E. Oehlke, H. T. Wolterbeek, J. R. van Ommen, A. G. Denkova^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

7 Citations (Scopus)

47 Downloads (Pure)

Abstract

New production routes for ⁹⁹Mo are steadily gaining importance. However, the obtained specific activity is much lower than currently produced by the fission of U-235. To be able to supply hospitals with ⁹⁹Mo/^99mTc generators with the desired activity, the adsorption capacity of the column material should be increased. In this paper we have investigated whether the gas phase coating technique Atomic Layer Deposition (ALD), which can deposit ultra-thin layers on high surface area materials, can be used to attain materials with high adsorption capacity for ⁹⁹Mo. For this purpose, ALD was applied on a silica-core sorbent material to coat it with a thin layer of alumina. This sorbent material shows to have a maximum adsorption capacity of 120 mg/g and has a^99mTc elution efficiency of 55 ± 2% based on 3 executive elutions.

Original language	English
Article number	109266
Number of pages	9
Journal	Applied Radiation and Isotopes
Volume	164
DOIs	https://doi.org/10.1016/j.apradiso.2020.109266
Publication status	Published - 2020

Keywords

Mo/mTc
Sorbent materials

Access to Document

10.1016/j.apradiso.2020.109266

1-s2.0-S0969804320304164-mainFinal published version, 1.18 MBLicence: CC BY

Cite this

@article{4183bb63842740778466da881a65a7f2,

title = "The application of atomic layer deposition in the production of sorbents for 99Mo/99mTc generator",

abstract = "New production routes for 99Mo are steadily gaining importance. However, the obtained specific activity is much lower than currently produced by the fission of U-235. To be able to supply hospitals with 99Mo/99mTc generators with the desired activity, the adsorption capacity of the column material should be increased. In this paper we have investigated whether the gas phase coating technique Atomic Layer Deposition (ALD), which can deposit ultra-thin layers on high surface area materials, can be used to attain materials with high adsorption capacity for 99Mo. For this purpose, ALD was applied on a silica-core sorbent material to coat it with a thin layer of alumina. This sorbent material shows to have a maximum adsorption capacity of 120 mg/g and has a99mTc elution efficiency of 55 ± 2% based on 3 executive elutions.",

keywords = "Mo/mTc, Sorbent materials",

author = "Moret, {J. L.T.M.} and J. Alkemade and Upcraft, {T. M.} and E. Oehlke and Wolterbeek, {H. T.} and {van Ommen}, {J. R.} and Denkova, {A. G.}",

year = "2020",

doi = "10.1016/j.apradiso.2020.109266",

language = "English",

volume = "164",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier",

}

TY - JOUR

T1 - The application of atomic layer deposition in the production of sorbents for 99Mo/99mTc generator

AU - Moret, J. L.T.M.

AU - Alkemade, J.

AU - Upcraft, T. M.

AU - Oehlke, E.

AU - Wolterbeek, H. T.

AU - van Ommen, J. R.

AU - Denkova, A. G.

PY - 2020

Y1 - 2020

N2 - New production routes for 99Mo are steadily gaining importance. However, the obtained specific activity is much lower than currently produced by the fission of U-235. To be able to supply hospitals with 99Mo/99mTc generators with the desired activity, the adsorption capacity of the column material should be increased. In this paper we have investigated whether the gas phase coating technique Atomic Layer Deposition (ALD), which can deposit ultra-thin layers on high surface area materials, can be used to attain materials with high adsorption capacity for 99Mo. For this purpose, ALD was applied on a silica-core sorbent material to coat it with a thin layer of alumina. This sorbent material shows to have a maximum adsorption capacity of 120 mg/g and has a99mTc elution efficiency of 55 ± 2% based on 3 executive elutions.

AB - New production routes for 99Mo are steadily gaining importance. However, the obtained specific activity is much lower than currently produced by the fission of U-235. To be able to supply hospitals with 99Mo/99mTc generators with the desired activity, the adsorption capacity of the column material should be increased. In this paper we have investigated whether the gas phase coating technique Atomic Layer Deposition (ALD), which can deposit ultra-thin layers on high surface area materials, can be used to attain materials with high adsorption capacity for 99Mo. For this purpose, ALD was applied on a silica-core sorbent material to coat it with a thin layer of alumina. This sorbent material shows to have a maximum adsorption capacity of 120 mg/g and has a99mTc elution efficiency of 55 ± 2% based on 3 executive elutions.

KW - Mo/mTc

KW - Sorbent materials

UR - http://www.scopus.com/inward/record.url?scp=85086582523&partnerID=8YFLogxK

U2 - 10.1016/j.apradiso.2020.109266

DO - 10.1016/j.apradiso.2020.109266

M3 - Article

AN - SCOPUS:85086582523

SN - 0969-8043

VL - 164

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

M1 - 109266

ER -

The application of atomic layer deposition in the production of sorbents for ⁹⁹Mo/^99mTc generator

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this