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The Missing Link in the Pathophysiology of Vascular Cognitive Impairment : Design of the Heart-Brain Study. / Hooghiemstra, Astrid M.; Bertens, Anne Suzanne; Leeuwis, Anna E.; Bron, Esther E.; Bots, Michiel L.; Brunner-La Rocca, Hans Peter; De Craen, Anton J M; van der Geest, Rob J.; Greving, Jacoba P.; Kappelle, L. Jaap; Niessen, Wiro J.; van Oostenbrugge, Robert J.; van Osch, Matthias J P; de Roos, Albert; van Rossum, Albert C.; Biessels, Geert Jan; van Buchem, Mark A.; Daemen, Mat J A P; van der Flier, Wiesje M.

In: Cerebrovascular Diseases Extra, Vol. 7, No. 3, 2017, p. 140-152.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Hooghiemstra, AM, Bertens, AS, Leeuwis, AE, Bron, EE, Bots, ML, Brunner-La Rocca, HP, De Craen, AJM, van der Geest, RJ, Greving, JP, Kappelle, LJ, Niessen, WJ, van Oostenbrugge, RJ, van Osch, MJP, de Roos, A, van Rossum, AC, Biessels, GJ, van Buchem, MA, Daemen, MJAP & van der Flier, WM 2017, 'The Missing Link in the Pathophysiology of Vascular Cognitive Impairment: Design of the Heart-Brain Study' Cerebrovascular Diseases Extra, vol. 7, no. 3, pp. 140-152. https://doi.org/10.1159/000480738

APA

Hooghiemstra, A. M., Bertens, A. S., Leeuwis, A. E., Bron, E. E., Bots, M. L., Brunner-La Rocca, H. P., ... van der Flier, W. M. (2017). The Missing Link in the Pathophysiology of Vascular Cognitive Impairment: Design of the Heart-Brain Study. Cerebrovascular Diseases Extra, 7(3), 140-152. https://doi.org/10.1159/000480738

Vancouver

Hooghiemstra AM, Bertens AS, Leeuwis AE, Bron EE, Bots ML, Brunner-La Rocca HP et al. The Missing Link in the Pathophysiology of Vascular Cognitive Impairment: Design of the Heart-Brain Study. Cerebrovascular Diseases Extra. 2017;7(3):140-152. https://doi.org/10.1159/000480738

Author

Hooghiemstra, Astrid M. ; Bertens, Anne Suzanne ; Leeuwis, Anna E. ; Bron, Esther E. ; Bots, Michiel L. ; Brunner-La Rocca, Hans Peter ; De Craen, Anton J M ; van der Geest, Rob J. ; Greving, Jacoba P. ; Kappelle, L. Jaap ; Niessen, Wiro J. ; van Oostenbrugge, Robert J. ; van Osch, Matthias J P ; de Roos, Albert ; van Rossum, Albert C. ; Biessels, Geert Jan ; van Buchem, Mark A. ; Daemen, Mat J A P ; van der Flier, Wiesje M. / The Missing Link in the Pathophysiology of Vascular Cognitive Impairment : Design of the Heart-Brain Study. In: Cerebrovascular Diseases Extra. 2017 ; Vol. 7, No. 3. pp. 140-152.

BibTeX

@article{abb1f4becde444e39aab206b79acd7a3,
title = "The Missing Link in the Pathophysiology of Vascular Cognitive Impairment: Design of the Heart-Brain Study",
abstract = "Background: Hemodynamic balance in the heart-brain axis is increasingly recognized as a crucial factor in maintaining functional and structural integrity of the brain and thereby cognitive functioning. Patients with heart failure (HF), carotid occlusive disease (COD), and vascular cognitive impairment (VCI) present themselves with complaints attributed to specific parts of the heart-brain axis, but hemodynamic changes often go beyond the part of the axis for which they primarily seek medical advice. The Heart-Brain Study hypothesizes that the hemodynamic status of the heart and the brain is an important but underestimated cause of VCI. We investigate this by studying to what extent hemodynamic changes contribute to VCI and what the mechanisms involved are. Here, we provide an overview of the design and protocol. Methods: The Heart-Brain Study is a multicenter cohort study with a follow-up measurement after 2 years among 645 participants (175 VCI, 175 COD, 175 HF, and 120 controls). Enrollment criteria are the following: 1 of the 3 diseases diagnosed according to current guidelines, age ≥50 years, no magnetic resonance contraindications, ability to undergo cognitive testing, and independence in daily life. A core clinical dataset is collected including sociodemographic factors, cardiovascular risk factors, detailed neurologic, cardiac, and medical history, medication, and a physical examination. In addition, we perform standardized neuropsychological testing, cardiac, vascular and brain MRI, and blood sampling. In subsets of participants we assess Alz­heimer biomarkers in cerebrospinal fluid, and assess echocardiography and 24-hour blood pressure monitoring. Follow-up measurements after 2 years include neuropsychological testing, brain MRI, and blood samples for all participants. We use centralized state-of-the-art storage platforms for clinical and imaging data. Imaging data are processed centrally with automated standardized pipelines. Results and Conclusions: The Heart-Brain Study investigates relationships between (cardio-)vascular factors, the hemodynamic status of the heart and the brain, and cognitive impairment. By studying the complete heart-brain axis in patient groups that represent components of this axis, we have the opportunity to assess a combination of clinical and subclinical manifestations of disorders of the heart, vascular system and brain, with hemodynamic status as a possible binding factor.",
keywords = "Cardiovascular dysfunction, Carotid occlusive disease, Cerebral blood flow, Cerebral hypoperfusion, Cognitive decline, Heart failure, Small vessel disease",
author = "Hooghiemstra, {Astrid M.} and Bertens, {Anne Suzanne} and Leeuwis, {Anna E.} and Bron, {Esther E.} and Bots, {Michiel L.} and {Brunner-La Rocca}, {Hans Peter} and {De Craen}, {Anton J M} and {van der Geest}, {Rob J.} and Greving, {Jacoba P.} and Kappelle, {L. Jaap} and Niessen, {Wiro J.} and {van Oostenbrugge}, {Robert J.} and {van Osch}, {Matthias J P} and {de Roos}, Albert and {van Rossum}, {Albert C.} and Biessels, {Geert Jan} and {van Buchem}, {Mark A.} and Daemen, {Mat J A P} and {van der Flier}, {Wiesje M.}",
year = "2017",
doi = "10.1159/000480738",
language = "English",
volume = "7",
pages = "140--152",
journal = "Cerebrovascular Diseases Extra",
issn = "1664-5456",
publisher = "S. Karger AG",
number = "3",

}

RIS

TY - JOUR

T1 - The Missing Link in the Pathophysiology of Vascular Cognitive Impairment

T2 - Cerebrovascular Diseases Extra

AU - Hooghiemstra, Astrid M.

AU - Bertens, Anne Suzanne

AU - Leeuwis, Anna E.

AU - Bron, Esther E.

AU - Bots, Michiel L.

AU - Brunner-La Rocca, Hans Peter

AU - De Craen, Anton J M

AU - van der Geest, Rob J.

AU - Greving, Jacoba P.

AU - Kappelle, L. Jaap

AU - Niessen, Wiro J.

AU - van Oostenbrugge, Robert J.

AU - van Osch, Matthias J P

AU - de Roos, Albert

AU - van Rossum, Albert C.

AU - Biessels, Geert Jan

AU - van Buchem, Mark A.

AU - Daemen, Mat J A P

AU - van der Flier, Wiesje M.

PY - 2017

Y1 - 2017

N2 - Background: Hemodynamic balance in the heart-brain axis is increasingly recognized as a crucial factor in maintaining functional and structural integrity of the brain and thereby cognitive functioning. Patients with heart failure (HF), carotid occlusive disease (COD), and vascular cognitive impairment (VCI) present themselves with complaints attributed to specific parts of the heart-brain axis, but hemodynamic changes often go beyond the part of the axis for which they primarily seek medical advice. The Heart-Brain Study hypothesizes that the hemodynamic status of the heart and the brain is an important but underestimated cause of VCI. We investigate this by studying to what extent hemodynamic changes contribute to VCI and what the mechanisms involved are. Here, we provide an overview of the design and protocol. Methods: The Heart-Brain Study is a multicenter cohort study with a follow-up measurement after 2 years among 645 participants (175 VCI, 175 COD, 175 HF, and 120 controls). Enrollment criteria are the following: 1 of the 3 diseases diagnosed according to current guidelines, age ≥50 years, no magnetic resonance contraindications, ability to undergo cognitive testing, and independence in daily life. A core clinical dataset is collected including sociodemographic factors, cardiovascular risk factors, detailed neurologic, cardiac, and medical history, medication, and a physical examination. In addition, we perform standardized neuropsychological testing, cardiac, vascular and brain MRI, and blood sampling. In subsets of participants we assess Alz­heimer biomarkers in cerebrospinal fluid, and assess echocardiography and 24-hour blood pressure monitoring. Follow-up measurements after 2 years include neuropsychological testing, brain MRI, and blood samples for all participants. We use centralized state-of-the-art storage platforms for clinical and imaging data. Imaging data are processed centrally with automated standardized pipelines. Results and Conclusions: The Heart-Brain Study investigates relationships between (cardio-)vascular factors, the hemodynamic status of the heart and the brain, and cognitive impairment. By studying the complete heart-brain axis in patient groups that represent components of this axis, we have the opportunity to assess a combination of clinical and subclinical manifestations of disorders of the heart, vascular system and brain, with hemodynamic status as a possible binding factor.

AB - Background: Hemodynamic balance in the heart-brain axis is increasingly recognized as a crucial factor in maintaining functional and structural integrity of the brain and thereby cognitive functioning. Patients with heart failure (HF), carotid occlusive disease (COD), and vascular cognitive impairment (VCI) present themselves with complaints attributed to specific parts of the heart-brain axis, but hemodynamic changes often go beyond the part of the axis for which they primarily seek medical advice. The Heart-Brain Study hypothesizes that the hemodynamic status of the heart and the brain is an important but underestimated cause of VCI. We investigate this by studying to what extent hemodynamic changes contribute to VCI and what the mechanisms involved are. Here, we provide an overview of the design and protocol. Methods: The Heart-Brain Study is a multicenter cohort study with a follow-up measurement after 2 years among 645 participants (175 VCI, 175 COD, 175 HF, and 120 controls). Enrollment criteria are the following: 1 of the 3 diseases diagnosed according to current guidelines, age ≥50 years, no magnetic resonance contraindications, ability to undergo cognitive testing, and independence in daily life. A core clinical dataset is collected including sociodemographic factors, cardiovascular risk factors, detailed neurologic, cardiac, and medical history, medication, and a physical examination. In addition, we perform standardized neuropsychological testing, cardiac, vascular and brain MRI, and blood sampling. In subsets of participants we assess Alz­heimer biomarkers in cerebrospinal fluid, and assess echocardiography and 24-hour blood pressure monitoring. Follow-up measurements after 2 years include neuropsychological testing, brain MRI, and blood samples for all participants. We use centralized state-of-the-art storage platforms for clinical and imaging data. Imaging data are processed centrally with automated standardized pipelines. Results and Conclusions: The Heart-Brain Study investigates relationships between (cardio-)vascular factors, the hemodynamic status of the heart and the brain, and cognitive impairment. By studying the complete heart-brain axis in patient groups that represent components of this axis, we have the opportunity to assess a combination of clinical and subclinical manifestations of disorders of the heart, vascular system and brain, with hemodynamic status as a possible binding factor.

KW - Cardiovascular dysfunction

KW - Carotid occlusive disease

KW - Cerebral blood flow

KW - Cerebral hypoperfusion

KW - Cognitive decline

KW - Heart failure

KW - Small vessel disease

UR - http://resolver.tudelft.nl/uuid:abb1f4be-cde4-44e3-9aab-206b79acd7a3

UR - http://www.scopus.com/inward/record.url?scp=85031395489&partnerID=8YFLogxK

U2 - 10.1159/000480738

DO - 10.1159/000480738

M3 - Article

VL - 7

SP - 140

EP - 152

JO - Cerebrovascular Diseases Extra

JF - Cerebrovascular Diseases Extra

SN - 1664-5456

IS - 3

ER -

ID: 37137745