• Carolyn D Langen
  • Meike W. Vernooij
  • Lotte G M Cremers
  • Wyke Huizinga
  • Marius De Groot
  • M. Arfan Ikram
  • Tonya White
  • Wiro J. Niessen

Brain connectivity is increasingly being studied using connectomes. Typical structural connectome definitions do not directly take white matter pathology into account. Presumably, pathology impedes signal transmission along fibres, leading to a reduction in function. In order to directly study disconnection and localize pathology within the connectome, we present the disconnectome, which only considers fibres that intersect with white matter pathology. To show the potential of the disconnectome in brain studies, we showed in a cohort of 4199 adults with varying loads of white matter lesions (WMLs) that: (1) Disconnection is not a function of streamline density; (2) Hubs are more affected by WMLs than peripheral nodes; (3) Connections between hubs are more severely and frequently affected by WMLs than other connection types; and (4) Connections between region clusters are often more severely affected than those within clusters.

Original languageEnglish
Title of host publication2017 IEEE 14th International Symposium on Biomedical Imaging, ISBI 2017
ISBN (Electronic)978-150901171-1
Publication statusPublished - 2017
Externally publishedYes
Event14th IEEE International Symposium on Biomedical Imaging, ISBI 2017 - Melbourne, Australia
Duration: 18 Apr 201721 Apr 2017


Conference14th IEEE International Symposium on Biomedical Imaging, ISBI 2017

    Research areas

  • Connectome, Disconnection, Graph theory, Lesion, Pathology

ID: 37133580