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Trajectories of imaging markers in brain aging : the Rotterdam Study. / Vinke, Elisabeth J.; de Groot, Marius; Venkatraghavan, Vikram; Klein, Stefan; Niessen, Wiro J.; Ikram, M. Arfan; Vernooij, Meike W.

In: Neurobiology of Aging, Vol. 71, 01.11.2018, p. 32-40.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Vinke, EJ, de Groot, M, Venkatraghavan, V, Klein, S, Niessen, WJ, Ikram, MA & Vernooij, MW 2018, 'Trajectories of imaging markers in brain aging: the Rotterdam Study', Neurobiology of Aging, vol. 71, pp. 32-40. https://doi.org/10.1016/j.neurobiolaging.2018.07.001

APA

Vinke, E. J., de Groot, M., Venkatraghavan, V., Klein, S., Niessen, W. J., Ikram, M. A., & Vernooij, M. W. (2018). Trajectories of imaging markers in brain aging: the Rotterdam Study. Neurobiology of Aging, 71, 32-40. https://doi.org/10.1016/j.neurobiolaging.2018.07.001

Vancouver

Vinke EJ, de Groot M, Venkatraghavan V, Klein S, Niessen WJ, Ikram MA et al. Trajectories of imaging markers in brain aging: the Rotterdam Study. Neurobiology of Aging. 2018 Nov 1;71:32-40. https://doi.org/10.1016/j.neurobiolaging.2018.07.001

Author

Vinke, Elisabeth J. ; de Groot, Marius ; Venkatraghavan, Vikram ; Klein, Stefan ; Niessen, Wiro J. ; Ikram, M. Arfan ; Vernooij, Meike W. / Trajectories of imaging markers in brain aging : the Rotterdam Study. In: Neurobiology of Aging. 2018 ; Vol. 71. pp. 32-40.

BibTeX

@article{c71e148434594c48bc8637c348dc0e5b,
title = "Trajectories of imaging markers in brain aging: the Rotterdam Study",
abstract = "With aging, the brain undergoes several structural changes. These changes reflect the normal aging process and are therefore not necessarily pathologic. In fact, better understanding of these normal changes is an important cornerstone to also disentangle pathologic changes. Several studies have investigated normal brain aging, both cross-sectional and longitudinal, and focused on a broad range of magnetic resonance imaging (MRI) markers. This study aims to comprise the different aspects in brain aging, by performing a comprehensive longitudinal assessment of brain aging, providing trajectories of volumetric (global and lobar; subcortical and cortical), microstructural, and focal (presence of microbleeds, lacunar or cortical infarcts) brain imaging markers in aging and the sequence in which these markers change in aging. Trajectories were calculated on 10,755 MRI scans that were acquired between 2005 and 2016 among 5286 persons aged 45 years and older from the population-based Rotterdam Study. The average number of MRI scans per participant was 2 scans (ranging from 1 to 4 scans), with a mean interval between MRI scans of 3.3 years (ranging from 0.2 to 9.5 years) and an average follow-up time of 5.2 years (ranging from 0.3 to 9.8 years). We found that trajectories of the different volumetric, microstructural, and focal markers show nonlinear curves, with accelerating change with advancing age. We found earlier acceleration of change in global and lobar volumetric and microstructural markers in men compared with women. For subcortical and cortical volumes, results show a mix of more linear and nonlinear trajectories, either increasing, decreasing, or stable over age for the subcortical and cortical volume and thickness. Differences between men and women are visible in several parcellations; however, the direction of these differences is mixed. The presence of focal markers show a nonlinear increase with age, with men having a higher probability for cortical or lacunar infarcts. The data presented in this study provide insight into the normal aging process in the brain, and its variability.",
keywords = "Diffusion-MRI, Epidemiology, Gray matter, Longitudinal, MRI, Neurodegeneration, Population-based, White matter",
author = "Vinke, {Elisabeth J.} and {de Groot}, Marius and Vikram Venkatraghavan and Stefan Klein and Niessen, {Wiro J.} and Ikram, {M. Arfan} and Vernooij, {Meike W.}",
year = "2018",
month = nov,
day = "1",
doi = "10.1016/j.neurobiolaging.2018.07.001",
language = "English",
volume = "71",
pages = "32--40",
journal = "Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology",
issn = "0197-4580",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Trajectories of imaging markers in brain aging

T2 - the Rotterdam Study

AU - Vinke, Elisabeth J.

AU - de Groot, Marius

AU - Venkatraghavan, Vikram

AU - Klein, Stefan

AU - Niessen, Wiro J.

AU - Ikram, M. Arfan

AU - Vernooij, Meike W.

PY - 2018/11/1

Y1 - 2018/11/1

N2 - With aging, the brain undergoes several structural changes. These changes reflect the normal aging process and are therefore not necessarily pathologic. In fact, better understanding of these normal changes is an important cornerstone to also disentangle pathologic changes. Several studies have investigated normal brain aging, both cross-sectional and longitudinal, and focused on a broad range of magnetic resonance imaging (MRI) markers. This study aims to comprise the different aspects in brain aging, by performing a comprehensive longitudinal assessment of brain aging, providing trajectories of volumetric (global and lobar; subcortical and cortical), microstructural, and focal (presence of microbleeds, lacunar or cortical infarcts) brain imaging markers in aging and the sequence in which these markers change in aging. Trajectories were calculated on 10,755 MRI scans that were acquired between 2005 and 2016 among 5286 persons aged 45 years and older from the population-based Rotterdam Study. The average number of MRI scans per participant was 2 scans (ranging from 1 to 4 scans), with a mean interval between MRI scans of 3.3 years (ranging from 0.2 to 9.5 years) and an average follow-up time of 5.2 years (ranging from 0.3 to 9.8 years). We found that trajectories of the different volumetric, microstructural, and focal markers show nonlinear curves, with accelerating change with advancing age. We found earlier acceleration of change in global and lobar volumetric and microstructural markers in men compared with women. For subcortical and cortical volumes, results show a mix of more linear and nonlinear trajectories, either increasing, decreasing, or stable over age for the subcortical and cortical volume and thickness. Differences between men and women are visible in several parcellations; however, the direction of these differences is mixed. The presence of focal markers show a nonlinear increase with age, with men having a higher probability for cortical or lacunar infarcts. The data presented in this study provide insight into the normal aging process in the brain, and its variability.

AB - With aging, the brain undergoes several structural changes. These changes reflect the normal aging process and are therefore not necessarily pathologic. In fact, better understanding of these normal changes is an important cornerstone to also disentangle pathologic changes. Several studies have investigated normal brain aging, both cross-sectional and longitudinal, and focused on a broad range of magnetic resonance imaging (MRI) markers. This study aims to comprise the different aspects in brain aging, by performing a comprehensive longitudinal assessment of brain aging, providing trajectories of volumetric (global and lobar; subcortical and cortical), microstructural, and focal (presence of microbleeds, lacunar or cortical infarcts) brain imaging markers in aging and the sequence in which these markers change in aging. Trajectories were calculated on 10,755 MRI scans that were acquired between 2005 and 2016 among 5286 persons aged 45 years and older from the population-based Rotterdam Study. The average number of MRI scans per participant was 2 scans (ranging from 1 to 4 scans), with a mean interval between MRI scans of 3.3 years (ranging from 0.2 to 9.5 years) and an average follow-up time of 5.2 years (ranging from 0.3 to 9.8 years). We found that trajectories of the different volumetric, microstructural, and focal markers show nonlinear curves, with accelerating change with advancing age. We found earlier acceleration of change in global and lobar volumetric and microstructural markers in men compared with women. For subcortical and cortical volumes, results show a mix of more linear and nonlinear trajectories, either increasing, decreasing, or stable over age for the subcortical and cortical volume and thickness. Differences between men and women are visible in several parcellations; however, the direction of these differences is mixed. The presence of focal markers show a nonlinear increase with age, with men having a higher probability for cortical or lacunar infarcts. The data presented in this study provide insight into the normal aging process in the brain, and its variability.

KW - Diffusion-MRI

KW - Epidemiology

KW - Gray matter

KW - Longitudinal

KW - MRI

KW - Neurodegeneration

KW - Population-based

KW - White matter

UR - http://resolver.tudelft.nl/uuid:c71e1484-3459-4c48-bc86-37c348dc0e5b

UR - http://www.scopus.com/inward/record.url?scp=85050810099&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2018.07.001

DO - 10.1016/j.neurobiolaging.2018.07.001

M3 - Article

AN - SCOPUS:85050810099

VL - 71

SP - 32

EP - 40

JO - Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology

JF - Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology

SN - 0197-4580

ER -

ID: 46046042