TY - JOUR
T1 - Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery
AU - Kooiman, Klazina
AU - Roovers, Silke
AU - Langeveld, Simone A.G.
AU - Kleven, Robert T.
AU - Dewitte, Heleen
AU - O'Reilly, Meaghan A.
AU - Escoffre, Jean Michel
AU - Bouakaz, Ayache
AU - Verweij, Martin D.
AU - More Authors, null
PY - 2020
Y1 - 2020
N2 - Therapeutic ultrasound strategies that harness the mechanical activity of cavitation nuclei for beneficial tissue bio-effects are actively under development. The mechanical oscillations of circulating microbubbles, the most widely investigated cavitation nuclei, which may also encapsulate or shield a therapeutic agent in the bloodstream, trigger and promote localized uptake. Oscillating microbubbles can create stresses either on nearby tissue or in surrounding fluid to enhance drug penetration and efficacy in the brain, spinal cord, vasculature, immune system, biofilm or tumors. This review summarizes recent investigations that have elucidated interactions of ultrasound and cavitation nuclei with cells, the treatment of tumors, immunotherapy, the blood–brain and blood–spinal cord barriers, sonothrombolysis, cardiovascular drug delivery and sonobactericide. In particular, an overview of salient ultrasound features, drug delivery vehicles, therapeutic transport routes and pre-clinical and clinical studies is provided. Successful implementation of ultrasound and cavitation nuclei-mediated drug delivery has the potential to change the way drugs are administered systemically, resulting in more effective therapeutics and less-invasive treatments.
AB - Therapeutic ultrasound strategies that harness the mechanical activity of cavitation nuclei for beneficial tissue bio-effects are actively under development. The mechanical oscillations of circulating microbubbles, the most widely investigated cavitation nuclei, which may also encapsulate or shield a therapeutic agent in the bloodstream, trigger and promote localized uptake. Oscillating microbubbles can create stresses either on nearby tissue or in surrounding fluid to enhance drug penetration and efficacy in the brain, spinal cord, vasculature, immune system, biofilm or tumors. This review summarizes recent investigations that have elucidated interactions of ultrasound and cavitation nuclei with cells, the treatment of tumors, immunotherapy, the blood–brain and blood–spinal cord barriers, sonothrombolysis, cardiovascular drug delivery and sonobactericide. In particular, an overview of salient ultrasound features, drug delivery vehicles, therapeutic transport routes and pre-clinical and clinical studies is provided. Successful implementation of ultrasound and cavitation nuclei-mediated drug delivery has the potential to change the way drugs are administered systemically, resulting in more effective therapeutics and less-invasive treatments.
KW - Blood–brain barrier opening
KW - Bubble–cell interaction
KW - Cavitation nuclei
KW - Drug delivery
KW - Sonobactericide
KW - Sonoporation
KW - Sonothrombolysis
KW - Therapy
KW - Tumor
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=85081197938&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2020.01.002
DO - 10.1016/j.ultrasmedbio.2020.01.002
M3 - Review article
AN - SCOPUS:85081197938
SN - 0301-5629
VL - 46
SP - 1296
EP - 1325
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 6
ER -