• Matthijs van Kranenburg
  • Antonis Karanasos
  • Raluca Gabriela Chelu
  • Elco van der Heide
  • Mohamed Ouhlous
  • Koen Nieman
  • Nicolas van Mieghem
  • Gabriel Krestin
  • Wiro Niessen
  • Felix Zijlstra
  • Robert Jan van Geuns
  • Joost Daemen

Rationale and Objectives: Magnetic resonance angiography (MRA) is a well-established modality for the assessment of renal artery stenosis. Using dedicated quantitative analyses, MRA can become a useful tool for assessing renal artery dimensions in patients referred for renal sympathetic denervation (RDN) and for providing accurate measurements of vascular response after RDN. The purpose of this study was to test the reproducibility of a novel MRA quantitative imaging tool and to validate these measurements against intravascular ultrasound (IVUS). Materials and Methods: In nine patients referred for renal denervation, renal artery dimensions were measured. Bland-Altman analysis was used to assess the intraobserver and interobserver reproducibility. Results: Mean lumen diameter was 5.8 ± 0.7 mm, with a very good intraobserver and interobserver variability of 0.7% (reproducibility: bias, 0 mm; standard deviation [SD], 0.1 mm) and 1.2% (bias, 0 mm; SD, 0.1 mm), respectively. Mean total lumen volume was 1035.3 ± 403.6 mm3 with good intraobserver and interobserver variability of 2.9% (bias, -9.7 mm3; SD, 34.0 mm3) and 2.8% (bias, -11.4 mm3; SD, 42.4 mm3). The correlation (Pearson R) between mean lumen diameter measured with MRA and IVUS was 0.750 (P = .002). Conclusions: Using a novel MRA quantitative imaging tool, renal artery dimensions can be measured with good reproducibility and accuracy. MRA-derived diameters and volumes correlated well with IVUS measurements.

Original languageEnglish
Pages (from-to)1106-1114
JournalAcademic Radiology
Issue number9
Publication statusPublished - 2015
Externally publishedYes

    Research areas

  • Intravascular ultrasound, Magnetic resonance angiography, Percutaneous renal sympathetic denervation, Renal artery

ID: 47148179