TY - JOUR
T1 - Validation of Renal Artery Dimensions Measured by Magnetic Resonance Angiography in Patients Referred for Renal Sympathetic Denervation
AU - van Kranenburg, Matthijs
AU - Karanasos, Antonis
AU - Chelu, Raluca Gabriela
AU - van der Heide, Elco
AU - Ouhlous, Mohamed
AU - Nieman, Koen
AU - van Mieghem, Nicolas
AU - Krestin, Gabriel
AU - Niessen, Wiro
AU - Zijlstra, Felix
AU - van Geuns, Robert Jan
AU - Daemen, Joost
PY - 2015
Y1 - 2015
N2 - Rationale and Objectives: Magnetic resonance angiography (MRA) is a well-established modality for the assessment of renal artery stenosis. Using dedicated quantitative analyses, MRA can become a useful tool for assessing renal artery dimensions in patients referred for renal sympathetic denervation (RDN) and for providing accurate measurements of vascular response after RDN. The purpose of this study was to test the reproducibility of a novel MRA quantitative imaging tool and to validate these measurements against intravascular ultrasound (IVUS). Materials and Methods: In nine patients referred for renal denervation, renal artery dimensions were measured. Bland-Altman analysis was used to assess the intraobserver and interobserver reproducibility. Results: Mean lumen diameter was 5.8 ± 0.7 mm, with a very good intraobserver and interobserver variability of 0.7% (reproducibility: bias, 0 mm; standard deviation [SD], 0.1 mm) and 1.2% (bias, 0 mm; SD, 0.1 mm), respectively. Mean total lumen volume was 1035.3 ± 403.6 mm3 with good intraobserver and interobserver variability of 2.9% (bias, -9.7 mm3; SD, 34.0 mm3) and 2.8% (bias, -11.4 mm3; SD, 42.4 mm3). The correlation (Pearson R) between mean lumen diameter measured with MRA and IVUS was 0.750 (P = .002). Conclusions: Using a novel MRA quantitative imaging tool, renal artery dimensions can be measured with good reproducibility and accuracy. MRA-derived diameters and volumes correlated well with IVUS measurements.
AB - Rationale and Objectives: Magnetic resonance angiography (MRA) is a well-established modality for the assessment of renal artery stenosis. Using dedicated quantitative analyses, MRA can become a useful tool for assessing renal artery dimensions in patients referred for renal sympathetic denervation (RDN) and for providing accurate measurements of vascular response after RDN. The purpose of this study was to test the reproducibility of a novel MRA quantitative imaging tool and to validate these measurements against intravascular ultrasound (IVUS). Materials and Methods: In nine patients referred for renal denervation, renal artery dimensions were measured. Bland-Altman analysis was used to assess the intraobserver and interobserver reproducibility. Results: Mean lumen diameter was 5.8 ± 0.7 mm, with a very good intraobserver and interobserver variability of 0.7% (reproducibility: bias, 0 mm; standard deviation [SD], 0.1 mm) and 1.2% (bias, 0 mm; SD, 0.1 mm), respectively. Mean total lumen volume was 1035.3 ± 403.6 mm3 with good intraobserver and interobserver variability of 2.9% (bias, -9.7 mm3; SD, 34.0 mm3) and 2.8% (bias, -11.4 mm3; SD, 42.4 mm3). The correlation (Pearson R) between mean lumen diameter measured with MRA and IVUS was 0.750 (P = .002). Conclusions: Using a novel MRA quantitative imaging tool, renal artery dimensions can be measured with good reproducibility and accuracy. MRA-derived diameters and volumes correlated well with IVUS measurements.
KW - Intravascular ultrasound
KW - Magnetic resonance angiography
KW - Percutaneous renal sympathetic denervation
KW - Renal artery
UR - http://www.scopus.com/inward/record.url?scp=84938743585&partnerID=8YFLogxK
U2 - 10.1016/j.acra.2015.03.014
DO - 10.1016/j.acra.2015.03.014
M3 - Article
C2 - 26162249
AN - SCOPUS:84938743585
SN - 1076-6332
VL - 22
SP - 1106
EP - 1114
JO - Academic Radiology
JF - Academic Radiology
IS - 9
ER -