What makes long DNA short?: Modulation of DNA structure by Dps protein: cooperating & reorganizing

Natalia Vtyurina

doi:10.4233/uuid:14080918-3a6e-48ad-8c47-906538f689ac

What makes long DNA short? Modulation of DNA structure by Dps protein: cooperating & reorganizing

Natalia Vtyurina

Research output: Thesis › Dissertation (TU Delft)

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Abstract

Each confined cell created by nature and containing DNA molecule falls into the category of “alive organism”. All information about this organism is encoded in DNA molecule in genes, except of fate only. Along with the DNA molecule that represents genetic carrier, the organism neither the genome could function without proteins. Proteins are the building blocks from which cells are assembled and capable of activating or disabling particular genes playing a crucial role in DNA replication, repair and protection. In order to understand the function of each singular protein and its role in the overall cellular metabolism, we need to characterize it from different perspectives. Without this knowledge, we do not possess a complete picture of the vitally important processes in the cell and might be losing a very promising pipeline for a treatment of many diseases.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Delft University of Technology
Supervisors/Advisors	Dekker, N.H., Supervisor Abbondanzieri, Elio, Advisor
Award date	9 Sept 2016
Print ISBNs	978-90-8593-262-8
DOIs	https://doi.org/10.4233/uuid:14080918-3a6e-48ad-8c47-906538f689ac
Publication status	Published - 2016

Keywords

single-molecule
DNA condensation
Dps protein
cooperativity
reorganization
hysteresis
Ising model

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PhD thesis_Natalia VtyurinaFinal published version, 7.5 MB

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What makes long DNA short? Modulation of DNA structure by Dps protein: cooperating & reorganizing

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Keywords

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