• Carolyn D Langen
  • Hazel I. Zonneveld
  • Tonya White
  • Wyke Huizinga
  • Lotte G M Cremers
  • Marius De Groot
  • Mohammad Arfan Ikram
  • Wiro J. Niessen
  • Meike W. Vernooij

White matter lesions play a role in cognitive decline and dementia. One presumed pathway is through disconnection of functional networks. Little is known about location-specific effects of lesions on functional connectivity. This study examined location-specific effects within anatomically-defined white matter tracts in 1584 participants of the Rotterdam Study, aged 50–95. Tracts were delineated from diffusion magnetic resonance images using probabilistic tractography. Lesions were segmented on fluid-attenuated inversion recovery images. Functional connectivity was defined across each tract on resting-state functional magnetic resonance images by using gray matter parcellations corresponding to the tract ends and calculating the correlation of the mean functional activity between the gray matter regions. A significant relationship between both local and brain-wide lesion load and tract-specific functional connectivity was found in several tracts using linear regressions, also after Bonferroni correction. Indirect connectivity analyses revealed that tract-specific functional connectivity is affected by lesions in several tracts simultaneously. These results suggest that local white matter lesions can decrease tract-specific functional connectivity, both in direct and indirect connections.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalNeurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology
Publication statusPublished - 1 Mar 2017

    Research areas

  • Brain, Connectivity, Function, Lesions, Location-specific

ID: 33425426